I've become a big believer in really putting some time and effort into an "optimized" Arrow build.... optimum weight, FOC, spine and "efficiency".
I've harped on here before about the "Ashby studies" and I'll do it again now. His research involves a lot more than what some people think. It's not all about extreme FOC and heavy single bevel 2 blade broadheads... although I am now firmly in the camp of using an arrow setup with a more aggressive FOC (20% for me) and 2 blade single bevel broad heads on micro diameter shafts as well.
The "efficiency" part of it is something everyone should look into if you're thinking about taking longer shots (40 yards imo) at big game.
With my setup, the natural rotation of my arrow when released is counterclockwise or "left". This is solely due to how your string is twisted. There's an easy way to determine orientation. You just need to sacrifice the fletching on one of your shafts.
I now only shoot shafts fletched with a left wing orientation and single bevel 2 blade broad heads with a "left hand" orientation.
The resulting improvements in accuracy and penetration have been significant, which improves confidence... an intangible that cannot be overstated.
I used to shoot 55#. I've been shooting 70# for a couple years now and am pretty much maxed out there.
The most effective way to get used to such an increase for me has been steady and consistent practice. When I lay off for too long (a week for me), I struggle for a while, especially past 40.
Shooting a "better" bow also helps a ton.