Will discovering coronavirus 'dark matter' save us from the dreaded second wave?Another interesting article that discusses Sweden, but also talks about the dark matter theory, that a large portion of the population is simply immune to covid-19, due to immunity developed from other coronaviruses.
On Sweden, the point is made that a lot of articles have misinterpreted statements of Sweden's chief epidemiologist as admitting that not locking down was a mistake. That's not what he said; instead, he said that they made some mistakes, and of course, if they could do things over, they would change some things, but that it's still too early to make final assessments as to what.
Now, on to the more interesting part,
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This is now being challenged by studies suggesting many, perhaps most of us, might have some immunity because we fought off common colds (about a third of which are caused by coronaviruses). Researchers call it "cross-protective immunity". Anthony Costello, a former director of the World Health Organisation, who once feared the worst about the virus, says the new studies cast doubt on whether there will be a second wave after all.
The latest development came from a team in California who found a certain Covid response in the immune system of patients who recovered from Covid. Intriguingly, they discovered the same response in a control group who had never had the virus. This might, they said, point to some "cross-reactive, pre-existing immunity to Sars-CoV-2" in up to 60 per cent of people. It might help explain the mystery of the Diamond Princess, a cruise ship where Covid spread unchecked for a fortnight but only one in five passengers ended up catching it.
Karl Friston, a neuroscientist at University College London, put it well recently: there is some kind of immunological "dark matter" out there stopping the virus from infecting as many of us as had first been feared. No one is quite sure what it is, but it does seem to exist. Sunetra Gupta, Professor of Theoretical Epidemiology at Oxford University has made the same argument: that the virus has followed the same pattern worldwide, irrespective of various lockdown policies. Immunity, she says, is more likely to explain its demise.
Yonathan Freund, a professor of emergency medicine at the Sorbonne, has gone further and said a second wave can now be ruled out.
"Many of us realised that a good number of the population do not seem able to contract the virus," he said recently. "It's not clear why, but that's how it is." The immunological "dark matter" again. His conclusion: lockdown was vital, but the epidemic is over. To test his theory, he says, end lockdown now. "Closely monitor what happens. If it starts again, we will see it very quickly and take measures."
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We have enough data on Covid deaths to be able to work backwards, and estimate just how far the virus was spreading. The Norwegians did this last week and found that the virus peaked several days before lockdown. It was, for them, a big finding with big implications: in retrospect, says their health chief, lockdown was not needed. The virus could probably have been controlled with far lighter measures.
Now, the same study has been done for England and Wales. Prof Simon Wood of Bristol University shows the virus was falling fairly quickly by the time of lockdown, having peaked five days earlier. An important point, he says, when considering the "ethical" issues of a second lockdown and whether it would claim more life than it saves. But his study, like all such studies, emphasises how much we still don't know.
It's possible the virus is being halted by immunological dark materials. It's also possible that these dark materials don't exist, and that we are susceptible to a second wave. We can say that no country that has reopened has seen an overwhelming resurgence of the virus and that the world has decided that the greater risk lies in staying locked down. The doubt looks like being something we'll all have to live with.