Quote:
Patients who received one of the treatments of interest within 48 h of diagnosis were included in one of four treatment groups
Keegan99 said:
So yet another study that focuses on patients already hospitalized.
I feel like the general treatment protocol is more the issue than anything intentional.AG 2000' said:It's like they're trying to screw it up.Keegan99 said:
So yet another study that focuses on patients already hospitalized.
There is a large trial I think out of the UK that is doing some sort of prophylactic type of deal but won't be done until late summer.Quote:
Patients who received one of the treatments of interest within 48 h of diagnosis were included in one of four treatment groups (chloroquine alone, chloroquine with a macrolide, hydroxychloroquine alone, or hydroxychloroquine with a macrolide), and patients who received none of these treatments formed the control group. Patients for whom one of the treatments of interest was initiated more than 48 h after diagnosis or while they were on mechanical ventilation, as well as patients who received remdesivir, were excluded.
Ranger222 said:Quote:
Patients who received one of the treatments of interest within 48 h of diagnosis were included in one of four treatment groups
......
AG 2000' said:
Did I miss where the study combines HCQ and zinc? It mentions macrolides, but I don't see the zinc callout.
OldArmy71 said:
There are hundreds of thousands of people who for years have been taking hydroxy for RA and lupus and malaria, and they are not dying in droves.
Something else is at play here. I could be the COVID makes the heart more susceptible. I don't know.
amercer said:
https://www.washingtonpost.com/health/2020/05/22/hydroxychloroquine-coronavirus-study/
https://marlin-prod.literatumonline.com/pb-assets/Lancet/pdfs/S0140673620311806.pdf
"We were unable to confirm a benefit of hydroxychloroquine or chloroquine, when used alone or with a macrolide, on in-hospital outcomes for COVID-19. Each of these drug regimens was associated with decreased in-hospital survival and an increased frequency of ventricular arrhythmias when used for treatment of COVID-19."
BallerStaf2003 said:amercer said:
For any normal drug development, a result like this would be the absolute end of the program.
Most new drugs/ new indications we try fail. So any drug failing isn't a surprise, it's an expectation. Unfortunately this particular drug has become a political football, which makes everything much worse.
I still don't know what Trumps motivation is for continuing to go against his own administration on hydroxychloroquine.
Is it bc he stupidly touted the drug at the beginning as a game changer and his narcissism won't allow him to admit he's wrong?
Or is there some other interest there?
It boggles my mind why he continues to do something so wreckless.
Joe Exotic said:BallerStaf2003 said:
You already asked me that, troll.
And I'm not one to tell a doctor what to do with his patients. Not my right.
It's a message board. You can tell them anything you want.
Do you think doctors prescribing it are making a mistake?
culdeus said:
This has been a needless distraction and hopefully draws this discussion to a close. It's very sad that a drug became a battle line for some, in doing so it likely took resources away from real treatment protocol research.
Fitch said:
The drug has been known to have heart complications for ever. You have a novel virus that weakens your heart and blood along with lungs and other major organs.... not sure why it's any great surprise.
Still, I'm curious how to explain the anecdotal reports that seemed pretty consistently positive, even with the handful of "I treated 500 patients and they never got sick" stories that were unbelievable to start with.
Infection_Ag11 said:amercer said:
https://www.washingtonpost.com/health/2020/05/22/hydroxychloroquine-coronavirus-study/
https://marlin-prod.literatumonline.com/pb-assets/Lancet/pdfs/S0140673620311806.pdf
"We were unable to confirm a benefit of hydroxychloroquine or chloroquine, when used alone or with a macrolide, on in-hospital outcomes for COVID-19. Each of these drug regimens was associated with decreased in-hospital survival and an increased frequency of ventricular arrhythmias when used for treatment of COVID-19."
I'll be honest, I'm been skeptical of this therapy from the start and more concerned about the potential side effects than most and this study still shocks me. Even factoring in the cases of viral myocarditis, that's a HUGE increase in ventricular arrhythmias in a study with a large sample size.
Wow
alf83 said:Infection_Ag11 said:amercer said:
https://www.washingtonpost.com/health/2020/05/22/hydroxychloroquine-coronavirus-study/
https://marlin-prod.literatumonline.com/pb-assets/Lancet/pdfs/S0140673620311806.pdf
"We were unable to confirm a benefit of hydroxychloroquine or chloroquine, when used alone or with a macrolide, on in-hospital outcomes for COVID-19. Each of these drug regimens was associated with decreased in-hospital survival and an increased frequency of ventricular arrhythmias when used for treatment of COVID-19."
I'll be honest, I'm been skeptical of this therapy from the start and more concerned about the potential side effects than most and this study still shocks me. Even factoring in the cases of viral myocarditis, that's a HUGE increase in ventricular arrhythmias in a study with a large sample size.
Wow
