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What are your thoughts? Melee or projectile weapons? Combo of both?
I like using the powerfist and mostly try to close my distance rapidly with an enemy. Sniper rifle for distance encounters.
Right now I am going full on Rifle with two exceptions: Deliverer for short range stealth attacks and the power fist for melee if needed. Everything else is a silenced rifle some scoped (long range) some not (middle/short range) and I am working on maxing sneak, sandman, ninja and rifleman.
If you are going melee the Blitz perk seems to be a good option, allows you to VATS attack from a larger distance.