Teslag said:

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Madman said:

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Teslag said:

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BassCowboy33 said:

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Tramp96 said:

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But is it sustainable?

Even if there are no long-term side effects (and you know there will be), is this a sustainable approach to weight loss?

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Studies have shown that people gain the weight back upon stopping the drug. It's basically a "forever" drug. The long-term effects of paralyzing your internal organs isn't known at this time.

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It was originally a diabetic drug so it was designed to be taken long term with minimal side effects

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Cuz its just that easy and drug companies are super honest about things like that.

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You do realize there a significant number of drugs that are meant to be taken long term for many different ailments rightv

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Of course people responsible for different products intend and try to give those products certain properties. But then reality and human shortcomings get in the way.

https://www.hhrlaw.com/blog/2022/march/5-famous-drug-recalls-in-us-history-why-they-hap/

Teslag said:

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BassCowboy33 said:

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Tramp96 said:

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But is it sustainable?

Even if there are no long-term side effects (and you know there will be), is this a sustainable approach to weight loss?

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Studies have shown that people gain the weight back upon stopping the drug. It's basically a "forever" drug. The long-term effects of paralyzing your internal organs isn't known at this time.

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It was originally a diabetic drug so it was designed to be taken long term with minimal side effects

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Sure, sure, it wont be the first drug that was designed for a lot of things but years later we know its unsafe. Like CAR-T, took 7 years, but it was finally shown to induce Parkinsonism, it also was SAFE. lol

They are very effective but also very expensive and not fun to be on with the nausea and poor appetite. I bought stock in Novo and Lilly when the data was first coming out on them. Novo was at 65.81 and Lilly at 435 so that was a good investment so far!

Insurance refuses to cover these for weight loss which is very frustrating as a physician. Decades of data show that the typical dietary and lifestyle modifications are not effective for severe pediatric obesity. Right now we have to wait until the teens are diabetic then insurance will cover the treatment. At the same time they are getting taki's and coke for free on the tax dollar. It is so messed up!

There is real concern about treating as young as they are FDA approved (12+). They cause pretty drastic caloric restriction so in a growing child that could really hurt their skeletal and muscle mass for the entire life.

I meant to create a wonderful world where a berjillion problems could be accurately diagnosed with a single drop of blood.


Oops.

What about the ones that were indeed safe?

Cruiser87 said:

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I've been back and forth on the diet rollercoaster for many years.

After my latest gain, with all the associated back pain and other issues, I'm finally on a true lifestyle change, as opposed to lose it then forget it gaining it all back.

I have a way to go, but I will get there before my son's ring day this fall if it's the only thing I do.

And as far as I'm concerned, the real problem is all the sugar (read high fructose corn syrup) in everything.

P.S. Before anyone asks, I do a combination of dumbbell weights and walking. I don't want to end up with a lot of loose skin, though I need to deal with "turkey neck."

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No doubt our food system needs an overhaul in how it processes and produces food.

Sugar and the 8 or so seed oils are the biggest killers in our daily diets. They represent something like 70% of the calories we take in collectively, and they aren't good calories.

Most, if not all, of the seed oils that are used in the highest volumes today didn't even exist 100-120 years ago. But today they make up the largest percentage of calories we (as a country) intake. These oils are not particularly good for us, but production continues to increase and their use in every day foods continues to increase exponentially.

Genuinely pray it is safe in the long run. Lots of good people on it and it appears to be helping them. I'm just more skeptical of big pharma and popular new medications now more than ever...especially ones that cut corners and promise quick results.

Hopefully most people are motivated by the results and it drives them to the gym, to go for runs, and to maybe ween off the drug. That is where the true physical and mental rewards come from. Have a feeling most people are going to just keep doing the same.

MediAg13 said:

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There has been an uptick of people coming to the ER due to vomiting and dehydration related to increased doses of these medications. They'll be on a lower dose that is well tolerated and with good results but when they go up on the dosing they develop gastroparesis. They tend to be very resistant to telling their doctor and reducing the dosage because they want to see faster results.

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I know a 31 year old girl who is taking it (she looks unhealthy now) .. and she really didn't need it. Anyway she has been to the ER 3 times now in the last 6 weeks, having all kinds of issues. She is taking another drug (can't remember the name) and they aren't doing well together

I told her, why don't you just get off of the stuff? You know what's causing your problems…

She's still on it ..: she blames her recent problems on the other drug she takes ..

I have another friend that died in the last 6 months, he was in his early 40s …. He was on ozempic and didn't look healthy, he was also forced to take 3 covid shots due to his work, when he passed he had taken some other drugs, they (family) would not tell us the final cause of death, just that his heart stopped working. Anyway, after that I question what this stuff is doing to people? Now I know a second person (the chick above) and she is having health issues out of no where.

My opinion is that if your going to take these weight loss drugs, you need to be very careful what other things are going into your body at the same time .. just my 2 cents !

Kozmozag said:

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Novo nordisk is single handedly fixing the Netherlands economy...lol, they may actually meet their nato goals with the increased tax money.

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The actually run 2 different GDP reports...one WITH Novo Nordisk...and one without.

Losing weight but still pumping their bodies with garbage and not exercising.

are the doses the same for weight loss use vs diabetic use? Are the long term side effects the same for both?

arent these drugs like 1000 a month? I would think that we see impacts from insurance companies costs going through the roof.

Stonegateag85 said:

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Losing weight but still pumping their bodies with garbage and not exercising.

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Hey don't call me garbage. I have some self worth.

"forced to make any lifestyle modifications". It's always a choice. Whether this drug or in general. Even if they are diabetic or have heart disease. This doesn't take away a choice. Just resets the game to a better starting point for the patient to make that choice.

Rip*91 said:

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Good. People are trying to lose weight and take better care of themselves.

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Many long term studies show the weight comes back plus some.

Aggie95 said:

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are the doses the same for weight loss use vs diabetic use? Are the long term side effects the same for both?

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Same drug just higher dose for weight loss. Long term side effects are the same as far as current data shows.

El Gallo Blanco said:

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Genuinely pray it is safe in the long run. Lots of good people on it and it appears to be helping them. I'm just more skeptical of big pharma and popular new medications now more than ever...especially ones that cut corners and promise quick results.

Hopefully most people are motivated by the results and it drives them to the gym, to go for runs. That is where the true physical and mental rewards come from. Have a feeling most people are going to just keep doing the same.

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I'd hope they also use proper exercise and diet for losing weight as well, but at the end of the day, if that's losing weight and are being less of a strain in so many areas, what should it matter how they're doing it?

Also, the, "how do we know if it's safe" question isn't quite as effective when years and years start passing by and everyone taking isn't dropping dead.

If it works for them, good for them. It's no skin off my teeth.

schmellba99 said:

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Cruiser87 said:

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I've been back and forth on the diet rollercoaster for many years.

After my latest gain, with all the associated back pain and other issues, I'm finally on a true lifestyle change, as opposed to lose it then forget it gaining it all back.

I have a way to go, but I will get there before my son's ring day this fall if it's the only thing I do.

And as far as I'm concerned, the real problem is all the sugar (read high fructose corn syrup) in everything.

P.S. Before anyone asks, I do a combination of dumbbell weights and walking. I don't want to end up with a lot of loose skin, though I need to deal with "turkey neck."

---

No doubt our food system needs an overhaul in how it processes and produces food.

Sugar and the 8 or so seed oils are the biggest killers in our daily diets. They represent something like 70% of the calories we take in collectively, and they aren't good calories.

Most, if not all, of the seed oils that are used in the highest volumes today didn't even exist 100-120 years ago. But today they make up the largest percentage of calories we (as a country) intake. These oils are not particularly good for us, but production continues to increase and their use in every day foods continues to increase exponentially.

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This is not a trick question.

Explain the seed oil topic to me please. I have tried to understand but clearly something is not getting through. For example I don't see people saying don't eat the seeds these oils come from, just don't use the oil. Which is probably the root of my not understanding the problem.

That's wild? How tall are you? I'm currently 6'2 195, wouldn't hate losing an easy ten and dialing back working out 6 days a week.

Losing the weight is good. Not backfilling it with muscle gains and joint and bone strengthening is not so good. You are a somewhat lighter and healthier person but still with weaker frame and cardiovascular system than you should have.

Lower the dose and start working in actual exercise and some weight lifting. Even a little would go a long way.

My dad got on it. He's 72 and started getting big after he retired. He lost 40 pounds and was able to get off 2 blood pressure meds and a cholesterol pill.

I definitely his short term benefit will outweigh any longer term bad effects.

So you're cheering for people to have ill side effects from this? Pretty crappy of you.

No Spin Ag said:

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El Gallo Blanco said:

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Genuinely pray it is safe in the long run. Lots of good people on it and it appears to be helping them. I'm just more skeptical of big pharma and popular new medications now more than ever...especially ones that cut corners and promise quick results.

Hopefully most people are motivated by the results and it drives them to the gym, to go for runs. That is where the true physical and mental rewards come from. Have a feeling most people are going to just keep doing the same.

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I'd hope they also use proper exercise and diet for losing weight as well, but at the end of the day, if that's losing weight and are being less of a strain in so many areas, what should it matter how they're doing it?

Also, the, "how do we know if it's safe" question isn't quite as effective when years and years start passing by and everyone taking isn't dropping dead.

If it works for them, good for them. It's no skin off my teeth.

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It's still new right? Do we have years and years of data in terms of real world use outside of testing? So far, I have heard of a few family friends and friends of friends who seem to have had stomach or digestive issues.

It is very likely a good thing overall....sounds like it. But the jury is still out in terms of long term effects imo.

I think it is the caloric density. A very small amount will contain a lot of calories the body will digest and add to body fat if they aren't metabolized. I think it is just that a little goes a long way, but food today contains a LOT of it.

Thunderstruck xx said:

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The "throw medication at everything" solution by doctors today is so bad that when I visit any doctor and tell them I'm not on any medications, most of them look surprised.

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They get a massive selection bias.

Most docs don't see healthy people. Emergency rooms and OB/GYNs as needed, but I don't even see the point in a passive wellness checkup, and won't make it to any specialists.
"Any big complaints?"
"No"
"Ok - you're healthy."
"I know."
"Cool. Thanks for wasting both of our time. You can pay on the way out."

My wife and I took the shots from June 2022 until April 2023 - it was supposed to be a 6 month program but they shipped us some extra shots before we stopped the program. Over that time I lost 45 lbs and my wife lost about the same. It was $400 a month for each of us as insurance wouldn't cover it. We asked to suspend our program for a bit and then get back on later but the price had already gone up to $650 a month.

My PCP originally recommended taking it - he ended up leaving the main practice to go work at their "concierge" office - definitely was banking money off it.

Since getting off of it, I have gained about 25 lbs back. While on it my appetite definitely was affected - certain meals I had a couple bites and had to stop. I also had several instances of nausea and throwing up - mostly when I was drinking alcohol. My wife has gained most of her weight back.

I definitely planned to keep it off but at 53 with 3 back surgeries (2 fusions), knee surgery (scope but need a replacement) and a hernia surgery, it's hard for me to maintain any significant exercise program. Even walking has spurred on serious knee pain. We have a pool so I like to swim laps in the warmer months - about time to get that going. I am 100% to blame for my weight - drinking and eating crap and know I need to change things.

Interestingly, I was talking to my cardiologist during my last appointment, and he mentioned my weight gain. I told him I had taken the GLP shots - he said he would soon be able to prescribe them because of the health benefits they provide. He even suggested I get back on them if I felt like I needed to. That surprised me a bit - but if cardiologists are recommending them, I would think they would be pretty safe. Obviously it's a bit early to know though.

Bottom line - I'm glad I did it but am disappointed in myself for not being sustaining my weight through normal means after stopping. I would recommend it to anyone who has tried everything to lose weight but can't - just know you'll have to deal with the side effects and expect to probably gain some back after getting off - how much will be up to you.

El Gallo Blanco said:

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No Spin Ag said:

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El Gallo Blanco said:

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Genuinely pray it is safe in the long run. Lots of good people on it and it appears to be helping them. I'm just more skeptical of big pharma and popular new medications now more than ever...especially ones that cut corners and promise quick results.

Hopefully most people are motivated by the results and it drives them to the gym, to go for runs. That is where the true physical and mental rewards come from. Have a feeling most people are going to just keep doing the same.

---

I'd hope they also use proper exercise and diet for losing weight as well, but at the end of the day, if that's losing weight and are being less of a strain in so many areas, what should it matter how they're doing it?

Also, the, "how do we know if it's safe" question isn't quite as effective when years and years start passing by and everyone taking isn't dropping dead.

If it works for them, good for them. It's no skin off my teeth.

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It's still new right? Do we have years and years of data in terms of real world use outside of testing? So far, I have heard of a few family friends and friends of friends who seem to have had stomach or digestive issues.

It is very likely a good thing overall....sounds like it. But the jury is still out in terms of long term effects imo.

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It is not new. The weight loss was basically a mistake/side effect that they saw in the FDA approval studies then ran more studies at higher dosing to prove it.

They were first approved in 2005, so nearly 20 years of data now.

From injections to pills: FDA approves first oral GLP-1 for type 2 diabetes - Pharmaceutical Technology (pharmaceutical-technology.com)

I met two people on this type of med last week. The male went from 410 to 360 in 6 months. The female went from 250 to 180 in 6 months. They started after a family member lost mega weight and recommended it.


Seems like any weight loss for folks this big is key to survival...regardless of regular side effects.

MouthBQ98 said:

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I think it is the caloric density. A very small amount will contain a lot of calories the body will digest and add to body fat if they aren't metabolized. I think it is just that a little goes a long way, but food today contains a LOT of it.

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It would seem something not metabolized would not end up as fat or anything else for that matter.

I saw a few meme type posts claiming seed oils were bad because they were originally made to be an industrial lubricant. Which might be true, but doesn't tell me much about the health impact.

Just because I might be able to lube a door hinge with a seed oil doesn't mean its bad to also eat. Strange yes, but not necessarily bad.

Just two weeks to flatten the curve(s). Where have we heard this before.

KidDoc said:

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El Gallo Blanco said:

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No Spin Ag said:

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El Gallo Blanco said:

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Genuinely pray it is safe in the long run. Lots of good people on it and it appears to be helping them. I'm just more skeptical of big pharma and popular new medications now more than ever...especially ones that cut corners and promise quick results.

Hopefully most people are motivated by the results and it drives them to the gym, to go for runs. That is where the true physical and mental rewards come from. Have a feeling most people are going to just keep doing the same.

---

I'd hope they also use proper exercise and diet for losing weight as well, but at the end of the day, if that's losing weight and are being less of a strain in so many areas, what should it matter how they're doing it?

Also, the, "how do we know if it's safe" question isn't quite as effective when years and years start passing by and everyone taking isn't dropping dead.

If it works for them, good for them. It's no skin off my teeth.

---

It's still new right? Do we have years and years of data in terms of real world use outside of testing? So far, I have heard of a few family friends and friends of friends who seem to have had stomach or digestive issues.

It is very likely a good thing overall....sounds like it. But the jury is still out in terms of long term effects imo.

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It is not new. The weight loss was basically a mistake/side effect that they saw in the FDA approval studies then ran more studies at higher dosing to prove it.

They were first approved in 2005, so nearly 20 years of data now.

From injections to pills: FDA approves first oral GLP-1 for type 2 diabetes - Pharmaceutical Technology (pharmaceutical-technology.com)

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Then I'd imagine it's as safe as other drugs then.

Thanks for the info.

KidDoc said:

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El Gallo Blanco said:

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No Spin Ag said:

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El Gallo Blanco said:

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Genuinely pray it is safe in the long run. Lots of good people on it and it appears to be helping them. I'm just more skeptical of big pharma and popular new medications now more than ever...especially ones that cut corners and promise quick results.

Hopefully most people are motivated by the results and it drives them to the gym, to go for runs. That is where the true physical and mental rewards come from. Have a feeling most people are going to just keep doing the same.

---

I'd hope they also use proper exercise and diet for losing weight as well, but at the end of the day, if that's losing weight and are being less of a strain in so many areas, what should it matter how they're doing it?

Also, the, "how do we know if it's safe" question isn't quite as effective when years and years start passing by and everyone taking isn't dropping dead.

If it works for them, good for them. It's no skin off my teeth.

---

It's still new right? Do we have years and years of data in terms of real world use outside of testing? So far, I have heard of a few family friends and friends of friends who seem to have had stomach or digestive issues.

It is very likely a good thing overall....sounds like it. But the jury is still out in terms of long term effects imo.

---

It is not new. The weight loss was basically a mistake/side effect that they saw in the FDA approval studies then ran more studies at higher dosing to prove it.

They were first approved in 2005, so nearly 20 years of data now.

From injections to pills: FDA approves first oral GLP-1 for type 2 diabetes - Pharmaceutical Technology (pharmaceutical-technology.com)

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Crazy, did not know that. Hope it's great for the individuals, as well as society...ummm...


at large.

Madman said:

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MouthBQ98 said:

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I think it is the caloric density. A very small amount will contain a lot of calories the body will digest and add to body fat if they aren't metabolized. I think it is just that a little goes a long way, but food today contains a LOT of it.

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It would seem something not metabolized would not end up as fat or anything else for that matter.

I saw a few meme type posts claiming seed oils were bad because they were originally made to be an industrial lubricant. Which might be true, but doesn't tell me much about the health impact.

Just because I might be able to lube a door hinge with a seed oil doesn't mean its bad to also eat. Strange yes, but not necessarily bad.

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This, I could probably lube a firearm with olive oil, which is healthy.

I've heard people claim seed oils cause significant inflammation though. Who knows? I try to stick to olive oil and oilive oil based butter though, as those are more time tested.

Back in the late 90s and early 2000s hydroxcut had ephedrine in it and that was incredible. I lost 40lbs in two months. Luckily, I've quit sodas and cut back on sugar so I've kept my weight pretty close to what I ended up at.