I have always been a huge far side fan. Looking at every strip in this thread, some I had never seen before, I instantly laugh. It's one frame with few words, sometimes none needed at all.
I read through all the calvin and hobbes strips in this thread too, and I only really laughed at the one where he's nailing the table.
It's amazing to me what Larson did with one frame. Some of these calvin and hobbes are long and drawn out (like the one where he's selling lemonade), and then the punchline is predictable and/or just moderately funny.
Larson def. had a Stephen Wright/Mitch Hedberg type of vibe, and I love both of those comics. Very normal, mundane, everyday stuff, but makes you look at it a different way.
The far side is instantly recognizable, even though he never reused characters. You could change the look of the art, and likely still know it's Larson.
And as someone said before.. the topics are just so unique.. death, destruction, stupidity.. all in a one frame comic. This is completely unique and innovative. Then you have the ongoing look into what animals are thinking, which just connects with anyone and everyone.