Hours 20-40 were pretty bad for me. Was mostly back to normal by hour 48.

Edit: Here's my exact experience

Vaccinated with Pfizer around 1600 on 12/22:
-Woke up 14 hours post vaccination with a slightly sore arm, some headache, but I had a little bit of a headache going into the vaccination. Otherwise felt ok
-18 hours post vaccine started feeling a little fatigued with some mildly sensitive skin and low back myalgias
-20-28 hours post vaccine started getting really fatigued, started feeling warm (temp peaked at 98.5), whole body felt pretty achy and sensitive, headache same intensity
-Attempted to sleep 28-38 hours post vaccination, but couldn't fall asleep for hours, very achy, warm, uncomfortable. Woke up multiple times through the night. Resting heart rate was in the 70's, when it's normally in the 60s
-Around hour 36/37 post vaccination I started feeling ok and was able to sleep a little
-Hours 38-48 felt tired, but probably because of a lack of sleep more than anything else, but started noticing some MSK pains, and stiffness, like my old sciatica coming back
-Hours 54-62, slept really well
-Hours 62 onwards, pretty much back to normal. But I attempted to go for a run, and was slower than normal and developed a side stich that I normally don't get.
-At hour 72, decided to take some naproxen even though I'm pretty much back to normal (I think). Minimal arm soreness/trigger point at injection site.

Wondering if I had an asymptomatic infection at some point.

By far the most common I have heard reported is injection site pain and swelling, which is what I experienced. A few colleagues also experienced body aches and fatigue. Nothing major though.

A friend had low grade fever and nights sweats on day and 2 and 3 after getting the vaccine. But he also says he had a bad reaction to the Shingles vaccine - might just be bad genes.

Felt about as sore as a tetanus shot for me. Other than arm soreness, I had zero issues with the first shot (got it last Thursday). We shall see what shot 2 brings.

On another note, my brother (also a physician) had COVID back in June. He had more systemic symptoms with his first shot (fevers, chills, etc). This makes sense immunologically if he still had antibodies from the original infection.

GAC06 said:

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Can someone explain why this vaccine would cause symptoms? I thought the mRNA vaccine was supposed to avoid that.

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The symptoms are caused by your body attacking the spike protein that the vaccine cause your cells to manufacture. In short, the symptoms are a sign of your immune system working properly

Wife and I both had Moderna and had no side effects except woke up today(day after injection) with a sore arm at injection area. Otherwise, we've both felt perfectly normal.

Arm pain for several days.

So people who have had covid are getting the vaccine? I thought the verdict was still out on that?

88planoAg said:

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So people who have had covid are getting the vaccine? I thought the verdict was still out on that?

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Yea seems like they should be last, minus a couple of narrow exceptions.