Appreciate the info on this thread. Does anyone have any anecdotal experience with a peptide combination that improves cognition as well as body composition? Would love to hear your experience.

Yes I'm running a neuro stack right now. N-acetyl Semax at 300mcg AM, Nuerospark 0.2 ml AM. Then running pinealon 1MG PM for a few weeks to prep for a 10 day Nuero blast of cerebrolysin and cortexin.

Other good brain peptides you can look into are Adamax, Dihexa, p21, noopept, j147.

2-2.5 mg/day on TB-500?

Sounds a little high, even for acute injury recovery.

https://www.skool.com/jh-iron-forge-brotherhood/classroom/8b207152?md=9633c4cc400f4cf1b9f23b5cf21b6a29

Im no expert, but I've found this site very helpful with regard to dosing:

https://www.skool.com/jh-iron-forge-brotherhood/classroom/8b207152?md=menu

Moses, to your knowledge are there any issues combing Tesa and a glp-1?

No you're good. They are completely separate pathways. I would recommend Reta split up 3x per week starting at 1-2mg per week.

Tesa 2mg at night for 8 weeks. You can keep running the Reta if you keep your doses low.

Cliff Booth said:

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2-2.5 mg/day on TB-500?

Sounds a little high, even for acute injury recovery.

https://www.skool.com/jh-iron-forge-brotherhood/classroom/8b207152?md=9633c4cc400f4cf1b9f23b5cf21b6a29

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What makes you say that dose is too high to run for 8-10 weeks?

That link you posted doesn't have any information. Just a link to join the iron brotherhood group.

When I click on the link, I get dosing basics for a all the peptides discussed here.

Maybe one has to join the group to see the info. Didn't know.

Not saying the following is gospel, but the site lays out protocols better than other places I've found:

"Dosing Protocol

TB-500 has a relatively long half-life (approximately 10 days), which allows for less frequent dosing compared to many other peptides. Protocols typically follow a loading phase followed by maintenance.

Standard Protocol

Loading Phase:

Dose: 2 to 2.5 mg twice weekly

Total: 4 to 5 mg per week

Duration: 4 to 6 weeks

Schedule: Monday/Thursday or Tuesday/Friday (3 to 4 days apart)

Maintenance Phase:

Dose: 2 to 2.5 mg once every 1 to 2 weeks

Duration: As needed for ongoing recovery

By Application

Acute injury recovery:

Loading: 4 to 6 mg per week for 4 to 6 weeks

Maintenance: 2 to 4 mg every 1 to 2 weeks

Chronic injury or joint support:

Loading: 4 to 5 mg per week for 6 weeks

Maintenance: 2 mg every 2 weeks as needed

May extend to 8 to 12 weeks with tapering

Post-surgical recovery:

Loading: 4 to 6 mg per week for 4 to 6 weeks

Maintenance: 2 mg weekly until recovered

General maintenance:

Dose: 2 to 2.5 mg once every 2 weeks

Administration

TB-500 works systemically, meaning it distributes throughout your body regardless of where you inject it. You do not need to inject near the injury site. Subcutaneous injection into the abdominal area or thigh is most common. Intramuscular injection is also used by some.

Cycle Length

Most protocols run 4 to 6 weeks for acute injuries. Chronic injuries may require 8 to 12 weeks with tapering. After completing a cycle, take 2 to 4 weeks off before starting another if needed."

That protocol I posted is the OG "Wolverine stack" based on a ton of studies etc. Dr. Seeds, Jay Campbell, Ben Greenfield etc. The common dose range would be around 7.5-15 mg per week, EOD or I like 5 days on 2 days off, same with HGH and/or the GH secretogues that supplement the healing stack. (5/2)

Edit: just looked up the old Dr. Seeds stuff and he does have some lower tb500 dose ranges.


That's the standard protocol that's been used for many many years. Long before this stuff became quasi mainstream.

That being said, things are always changing in this field so if there is another study or justification for going lower on tb-500 I would be happy to read it.

These doses are just the tried and true injury healing protocol. But it's never a bad idea to start lower and go higher later. But injured people usually are doing this to heal quicker and that Wolverine Stack is very safe and well tolerated.

Also, after 12 weeks the effectiveness drops by 70% so the fact they are recommending small weekly or bi-weekly "maintenance" doses without a true receptor break seems like really poor advice and waste of peptides.

After 12 weeks you should go on an 8 week ARA290/KPV cycle if you still have a lingering injury to help with inflammation and give your receptors a break from bpc and tb500.

MosesHallEnforcer said:

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No you're good. They are completely separate pathways. I would recommend Reta split up 3x per week starting at 1-2mg per week.

Tesa 2mg at night for 8 weeks. You can keep running the Reta if you keep your doses low.

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This is week 4 of my reta cycle. Down 4.5 lbs doing only 0.5mg a week. Looking at adding tesa to help with belly fat but damn thats expensive.

Yeah tesamorelin is awesome if you can swing it.

If you decide to keep it up long term you can buy in bulk from some private suppliers and a save a bunch per vial, but if it's your first go, might as well just get 8 weeks worth and test it out.

It's great for visceral fat, that's the bad stuff around your organs. I would recommend getting a dexa scan before you start so you can track exactly how much fat you have lost and muscle gained.

I'm getting into my late 30s and starting to feel like I'm made of glass. I work out pretty hard and feel like I don't recover well and have these little niggling injuries. Right now I'm battling some knee tendinitis, lower abdomen pain from a strained muscle, and a shoulder issue.

Would peptides help bring some healing and also help me recover better in general? Would love to build some more muscle as well. I work out hard but would be considered a hard-gainer.

Yes, start at the beginning of this thread and report back with questions once you have read through it. That way we don't repeat the same stuff, links etc over and over!

You're in the right place!

Aggietaco said:

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Aggietaco said:

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Aggietaco said:

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Finally pulled the trigger on bpc and tb since I've been off pain meds following surgery for several days. I'm not sure I'll be able to provide any meaningful anecdotal reporting for anyone else, but I'll try to keep a journal of my experience and update here periodically.

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Speaking of the miracle for healing, I'm in week 2 of bpc and tb. Obviously no anecdotal evidence yet, but I'm hoping it will hasten my recovery. PT on the Achilles repair starts this week and I'm anxious to start some mobility work on my ankle since I've been pretty timid about even moving it when I'm not wearing my boot. I spoke with my ortho about my plan ahead of my first injections and he's not sold on the treatment since there is not much significant research, but agreed to help me track recovery against similar aged males as a data point.

The injections have been way easier than I imagined, as someone who is deathly afraid of needles. I've been doing my 250 mcg (of each bpc and tb) pins nightly with the .5cc 31g syringes, alternating right and left side of my stomach and the needle is probably the easiest part. I've only had some slight discomfort at the injection site once, and I think that can be attributed to swabbing with an alcohol pad immediately after injecting that caused some irritation.

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Updating this since it's been 3 weeks from my last.

I'm now in week 5 of my regimen. I did increase my injections to 500 mcg of each about 10 days ago to up the tb amount to 3.5 mg/week. I don't have any evidence of (more) rapid recovery from my surgery yet, as expected, but my physical therapy is going well. The biggest hindrance I have to improvement from surgery is still swelling that I am working to combat with my PT, massage, ice, heat, and elevation.

I do plan to continue injections after a week or so break when I finish my current supply in about 14 more days. That would put 1st cycle around 7.5 weeks long. Based on input from here and elsewhere, I plan to separate my bpc and tb injections when I have to replenish my supply to increase my tb dosage and maintain the 500 mcg/day bpc dose. I haven't decided on adding tesa or ipa to the mix yet.

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Updating again.

I've finished my first rounds of BPC and TB on 1/22. I ran through 2 10mg/10mg vials from 12/07-01/22 and finished my last 20 days with 500mcg of each per day. Still difficult to note any efficacy since I haven't been through surgery before to have a comparison, but my PT is still going well. I have 1 more week in my boot while out and about but have transitioned back to normal driving with my right (affected) foot and I wear normal athletic shoes around the house and for minimal excursions. I was able to start back to un-booted squats on an inclined squat sled earlier this week for the first time and saw no issues with pain in my Achilles. Swelling around my ankle continues to be the biggest limiting factor which is normal post-op.

I haven't purchased another regimen of BPC and TB yet, but plan to do so shortly to continue use for at least another round. Based on suggestions here and elsewhere, I will buy separate BPC and TB vials so I can increase the TB dosage without wasting the BPC. I'm not crazy about additional injections, but will probably stick to twice a week TB injections so that would only be 2 more sticks per week.

I'll update again in several weeks for posterity after I've started the next round.

Protip: You can combine the tb and bpc injections in the same syringe. Just draw each dose from the separate vials and do 1 shot instead of 2.

TBH, I have such an issue pulling air into the syringe each time, it would be easier to not try and cross the two. Not sure if it's the vials that PP uses or what, but about 75% of the time there is a trapped air bubble at the bung that pulls into the syringe that I have to expel.

I still haven't 100% figured out dosing, but I'm leaning towards 8mg of TB per week split into 2 doses and 250mcg of BPC daily for a 12 week period. Thought about scaling back the TB after the first 4 weeks to 6 and bumping the first month to 10.

Yeah, I still stand by my dosing recommendations in this thread, but obviously do whatever you think is best.

For the syringe, that is a bit weird you're having air bubble issues. Try pulling back the syringe to what you want to draw, I.e. pull back to a 10 if you're going to draw 10. Inject that amount of air into your vial, and turn the vial upside down and draw your dose. You shouldn't have any issues with an air bubble.

Im week 8 or 9 (been gone for 2 weeks so last pin was week 8) of low dose reta. Still not over 2mg a week and I must say it works very well. Appetite isnt gone but it's definitely less than it had been and is impossible to be eating too much. I can eat more now that I'm 2 weeks out from last dose but am still way below normal appetite. Nausea randomly comes up but I never actually get sick so that's the only unpleasant side effect I have noted.

I dont suggest flying on reta if you've had nausea unless you take some pepto or whatever works for you. The landing was bad today and I kept thinking "don't be that guy, don't be that guy" while looking for the barf bag. First time ever on in I cant even remember how many flights

How many days per week are you splitting that 2mg up?

Never went to every other day. I have not been scientific or stringent so it has been about every 4 days.

Well if you want to fix your nausea issue, split it up. Do it over 5 days and you should mitigate any side effects.

MosesHallEnforcer said:

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Well if you want to fix your nausea issue, split it up. Do it over 5 days and you should mitigate any side effects.

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Maybe but I'm guessing that if I'm having issues from start till now, with lose dose still, that I'll still have the problem. It's not too bad and I can handle it but it will not surprise me at all to see nausea as the only reason retatrutide doesnt come out as THE glp medicine to have

You do it your way then. There's ample evidence splitting up the glp1s over multiple days into microdoses is way better and takes away the bad side effects instead of flooding your system once or twice a week.

Reta will be the biggest glp-1 of all time as Lilly is coming out of FDA trials and is putting all their eggs in the Reta basket.

They are already threatening lawsuits on the compounders and research chemical companies.

TAMUallen said:

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MosesHallEnforcer said:

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Well if you want to fix your nausea issue, split it up. Do it over 5 days and you should mitigate any side effects.

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Maybe but I'm guessing that if I'm having issues from start till now, with lose dose still, that I'll still have the problem. It's not too bad and I can handle it but it will not surprise me at all to see nausea as the only reason retatrutide doesnt come out as THE glp medicine to have

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Wouldn't the nausea only aid in the weight loss?

How bad is it?

MosesHallEnforcer said:

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You do it your way then. There's ample evidence splitting up the glp1s over multiple days into microdoses is way better and takes away the bad side effects instead of flooding your system once or twice a week.

Reta will be the biggest glp-1 of all time as Lilly is coming out of FDA trials and is putting all their eggs in the Reta basket.

They are already threatening lawsuits on the compounders and research chemical companies.

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I know what youre saying but if pins at a very slowly rising and small dosage are giving me nausea then reducing from 3 or 4 days to every other or every day might be a futile effort. I'll avoid sticking myself more and hope that it either dissipates or I'll put up with it as needed.

I just don't know how they'll get over the nausea hurdle. I might be a unique case of somebody who responds very well even with low doses and due to my sensitivity then I'm more likely to get that side effect. We will see! I think it does great and will help a lot of people.

There's a saying of "reta face" and I would say it is real. It does seem to reduce inflammation in the face while reducing fat without giving an ozempic face that looks like a nutrient starved prisoner

What amount are you pinning every 4 days? 1 mg, 2mg?

Today I start my Peptide journey with a glo stack
I will post results when I can

Realized I wasn't getting the Reta dose I thought I was but I still felt a lot of it. It's not as much appetite suppression as it was clearing out food noise for me. Dropped quite a bit of weight on that dose (1mg instead of the 2mg I thought I was taking) so I think I'll stick with that dose for a bit longer.

Will likely be adding MOTS-C and Tesamorelin in the coming days, I have been overweight for a long time (apart from a brief spell in 2020 where I lost 85 pounds in 4 months and regained it in 6 months, not sure which is more impressive) so thinking the Tesa will help with visceral fat while the MOTS-C will help with maintaining metabolic rate with a reduced caloric intake.

You might look into running 3 weeks of SS-31 before you start MOTsC. If you were overweight, you would most likely get a ton of benefit from using the ss-31 to repair your mitochondria first, And then you would get way more out of your MOTSC after SS-31. That's the standard protocol your fist go round running the mitochondrial peptides.

Later on you can rotate them during the week. Right now I'm taking ss-31 Monday and Thursday and Motsc Tuesday and Friday.

That will be for 8 weeks and which will be prep for an 8 week cycle of Humanin.

You will get some good benefit from Tesamorelin alongside that. 2mg at night 5 days on 2 days off.

Appreciate that, had heard the same about SS-31