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Anxiety, Depression, OCD

31,575 Views | 156 Replies | Last: 9 mo ago by KSBogey
G. hirsutum Ag
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AgsMyDude said:

I am very curious about the enzyme re: serotonin/dopamine inhibition.

Did you get tested for this? If so what test or enzyme was checked?

I also suffer from anxiety/ocd that goes off the rails big time when conditions are right. SSRIs made me dull/zonked out as well.


Hey sorry for just now seeing this. I don't know what the enzyme is. My father is a retired doctor and he was talking about it with a psychiatrist once.

SSRIs had the same effect on me at first. Zoloft was probably the worst but it cleared after two weeks. Celexa wasn't as bad but again after 2 weeks it cleared. And oddly enough I had the exact same reaction after adding daily cannabis, after the high wore off I had that zonked out feeling for a while, but my body adjusted after a few weeks and it stabilized.

My email is in my profile. Feel free to contact me if you want to talk about it more. Sounds like you may have whatever type of depression I have.
G. hirsutum Ag
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jczar03 said:

This continues to be a great thread with a lot of useful experiences, recommendations and considerations. Thank you all! I'm going to do my best to get to the bottom of this and hopefully post some information one day that helped my daughter and will help someone else out there.


Another herbal I forgot to mention is St Johns Wort. You can get it at Walgreens. I haven't tried it personally but it's been used for a long time as a depression treatment. Might be something else to try
MarathonAg12
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I'm on Lexapro and it's amazing
Max Power
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I've been on THC/CBD for a couple weeks now and it's kind of a game changer. Anxiety will creep in from time to time but it fades as quickly as it comes on. If I keep myself calm, no big deal. Yesterday I took my kid to a birthday party, the place was absolute chaos, way too many people, my kid was in a mood as well so things could have gone sideways quickly. I was able to calm her down, and keep myself calm as well when my immediate reaction to walking in the door was let's GTFO of here. My wife has noticed as well because she asked me about bringing it with us to Disney in June. I let her know I'm pretty sure it's highly illegal to take any THC products on a plane so I think I'll have to go without it for a week while we are there. They have medical marijuana in FL as well but I don't have a card for there and even if I did it's a federal issue if you get on a plane with it. I just don't know if there's anyway to travel with the oil, pills, or edibles and not risk a severe consequence.
AgsMyDude
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What ratio are using? Did it true awhile to figure out what worked?
Max Power
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I'm using 2:1 CBD:THC, take 5 mg THC at night, 2.5 in the morning. That seems to be a good regimen for me. Didn't take long to figure out the dosage since I started at 2.5 mg at night only.
gratitudeandacceptance
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FWIW, we've flown with edibles (mints and gummies) several times with no problem. Very minimal amount.
Adverse Event
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Nobody cares about cannabis except small town cops.

Flights are simple. Biggest concern is having a "vape pen" on flight if any type.
gigemJTH12
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Max Power said:

I've been on THC/CBD for a couple weeks now and it's kind of a game changer. Anxiety will creep in from time to time but it fades as quickly as it comes on. If I keep myself calm, no big deal. Yesterday I took my kid to a birthday party, the place was absolute chaos, way too many people, my kid was in a mood as well so things could have gone sideways quickly. I was able to calm her down, and keep myself calm as well when my immediate reaction to walking in the door was let's GTFO of here. My wife has noticed as well because she asked me about bringing it with us to Disney in June. I let her know I'm pretty sure it's highly illegal to take any THC products on a plane so I think I'll have to go without it for a week while we are there. They have medical marijuana in FL as well but I don't have a card for there and even if I did it's a federal issue if you get on a plane with it. I just don't know if there's anyway to travel with the oil, pills, or edibles and not risk a severe consequence.
dude just put it in your checked bag. zero issues.
FTACo88-FDT24dad
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gigemJTH12 said:

forgive me if being too personal...is she single?

I know that in these times being single for someone her age can be tough if she is on social media. seeing everyones "perfect life" of getting engaged, married, pregnant can be tough for someone who is single.

creates a false perception that she is "behind" in life.

Very common and its sad.

And stepping away from social media is tough for people that age. I get it.
Amen. Get off all social media until stable enough to discern what's productive and what's BS. Most of it is BS. Stop staring at devices for extended periods.

Additionally, we had a pretty rough road with my daughter when she turned 16. We went from top level, club soccer player, G&T student to out of control, precipitous decline into self-destructive death spiral. We ended up making the brutally hard choice to have her taken to Wilderness Therapy and then a year in a Residential Treatment Center/School in Utah. We were convinced that she would be dead by the time she was 17 if we hadn't done what we did. She just turned 22, and while it hasn't all been glorious progress, she is 100% better today than she was then.

I share all that background to share this: properly diagnosing mental health disorders and then treating them effectively is like trying to rope the wind. We went through several therapists and different diagnoses until we finally found a good therapist at the RDC in Utah. After she left Utah and came home, we went through two more therapists, but she has made good progress and as recently as last week, the new therapist and the psychiatrist who she had seen recently collaborated on a new diagnoses that we all agreed seems to be the best and most accurate diagnose she's had. They are zeroing in on what is called Complex PTSD. And it started with a traumatic leg break at a soccer camp when she was 12. So, 10 years after that event, we are finally figuring it out.

Finding a good therapist/counselor with specific experience working with someone like your daughter is absolutely key. I would recommend trying as many as it takes until she connects with one. When it happens, you will know it. If you have any hesitations, find another one. I know that's hard, but otherwise you are wasting time and potentially even going backwards.

Lastly, pharmaceuticals have their place in a therapeutic program, but they are only part of the solution. The key to a long term improvement is effective therapy coupled with the appropriate drugs. And good therapy is HARD. It can be exhausting and emotionally draining, but if it's just unicorns and rainbows when you come out of therapy, then you're doing it wrong, in my opinion. At least that has been our experience.

Don't lose hope. It will get better.
G. hirsutum Ag
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Update?
jczar03
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I believe that my daughter is finally in a less stressful and more manageable environment for the first time in over 2 years. I'm praying that God gives her the strength to move forward on a path to recovery. I know this sounds strange, but with all the daily medication anxiety, we are checking into injections as an alternative.
jczar03
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Things turned south beginning on Sunday afternoon. We were able to get my daughter admitted into the Menninger Clinic this morning. Hoping and praying this makes a difference.
pinkdog
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Prayers and well wishes and good job on being bold enough to seek this treatment. It's a hard decision to go to a facility but if I can offer any encouragement, I've seen some people come out of programs like that and do beautifully.
Max Power
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I'm sorry to hear things took a turn for the worse only a week after you you had a reason for optimism. A step backward after moving forward is a double gut punch. You're such a great parent for refusing to give up on your child in her darkest hour, keep it up.
WolfCall
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Beta Lactolin is found in some fermented dairy products like Camembert and Brie cheeses. There are 13 articles found in medical journals on the possible therapeutic uses of Beta Lactolin.

I have pasted in below the citation and abstract on Beta Lactolin's antidepressant effect in mice.

I don't see a downside to eating 1/8 to 1/4 of a small wheel of Camembert or Brie Cheese each day.....

https://pubmed.ncbi.nlm.nih.gov/31666480/
Quote:

J Nutr Sci Vitaminol (Tokyo)
. 2019;65(5):430-434. doi: 10.3177/jnsv.65.430.
Antidepressant-Like Effect of Beta-Lactolin, a Glycine-Threonine-Tryptophan-Tyrosine Peptide
Yasuhisa Ano 1, Rena Ohya 1, Keiji Kondo 1
Affiliations collapse
Affiliation
1Research Laboratories for Health Science & Food Technologies, Kirin Company Ltd.
PMID: 31666480 DOI: 10.3177/jnsv.65.430

Abstract
The number of patients with mental illnesses, including depression, is rapidly increasing, and daily lifestyle is closely associated with the development of symptoms. Consequently, corrective measures, such as diet-based treatment for diseases, are receiving great attention. We previously showed that Beta-lactolin, a -lactopeptide of glycine-threonine-tryptophan-tyrosine peptide, inhibits monoamine oxidase and improves memory impairment in mice, but the effects on depression have not been investigated. Here we showed that Beta-lactolin improved depression-like behavior via dopamine-D1-like receptor. Orally administered Beta-lactolin reduced immobility time in tail suspension test (TST). Pretreatment with SCH23390, dopamine D1-like receptor antagonist, attenuated the reduction in TST by Beta-lactolin. These effects were observed by the treatment with whey digest rich in Beta-lactolin. In addition, Beta-lactolin increased the levels of dopamine in the frontal cortex associated with the depression-like behavior. The present study suggests that supplements or nutraceutical compounds in whey digests (such as Beta-lactolin) show antidepressant-like effect.

Keywords: dairy products; depression; dopamine; peptides; whey.

Similar articles
Beta-lactolin, a whey-derived glycine-threonine-tryptophan-tyrosine lactotetrapeptide, improves prefrontal cortex-associated reversal learning in mice.
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Biosci Biotechnol Biochem. 2020 May;84(5):1039-1046. doi: 10.1080/09168451.2020.1714424. Epub 2020 Jan 11.
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STAFF: I had to go back and edit by inserting the word "Beta" as TexAgs doesn't allow the Beta character
I voted for this because I like Mean Tweets!
jczar03
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Has anyone had any experience with ECT (electroconvulsive therapy)?

Adverse Event
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Read some about it, it's vastly different than Hollywood presents.

Seems to be relatively highly regarded. It's amazing what electrical impulses can do to the neural network, I'd still be a little uncertain despite all the acclamation.

Someone else mentioned psychedelics or retreats being effective as well. Any pursuit there? There's one in Jamaica called Blue Portal I've heard positive things about. https://mushroommountain.com/blue-portal/?


Builder93
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Max Power
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Out of nowhere my six year old daughter is having anxiety issues. She doesn't want to go to school in the morning, she didn't want to go to soccer this weekend. She's worried something bad is going to happen. She can't tell us why, this morning was the worst it's been, she cried all morning long and then when we got to school the principal had to walk with her to get her out of the van to go in. We've been to our family counselor that's been helping her with other things, we've talked to the school, we've been to the pediatrician, nothing has come of those to help us. This is wearing on my wife and I both in a very serious way, we don't know how to help her, she had us both in tears this morning. I finally have my anxiety under control, but this has hit me like a ton of bricks and this takes my anxiety to a worse place than it was before. We feel so helpless and lost as parents. She doesn't really eat anything in the morning anymore, we don't think she's eating at school either. We keep asking why she's so worried about school and she can't explain it. We can't make any sense of it and it's breaking us down each individually. School ends in a few weeks, but she'll have camps and activities she has to do each day so we can work. We just don't know what we can do to help her.
BQ2001
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When my daughter was 6 she went through something like that. Someone left a TV on at Christmas and she saw about 10 seconds of a violent movie and got really upset at night about death and people hurting each other. We started playing meditation music on an Alexa in her room and got her a weighted blanket. Also we just stopped having the TV on at all in the evenings as some commercials were a little more adult than she liked. Lots of reading happy stories helped too.

I'm not sure if that is the case there, but I think it's normal for kids that age to be scared of death and not able to process it. We aren't super religious, but talking about heaven and going to a better place after dying helped too.
Max Power
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There are some things we're trying to parse through. Last week they had both an intruder drill and a tornado drill. Also, she hasn't seen her grandparents in over a week, she's used to seeing them more often. I think there's a chance she has some separation anxiety over them, and it's manifesting that she doesn't want to leave us. Everything appears to be fine once she's at school based on our conversation with the principal. Her trigger for some reason is leaving us and going to the school.

I would be more concerned about a specific traumatic event at the school if she was like that all day, but she's not. She calms down and gets back to normal.

This morning was tough, it was the only one this week we weren't able to calm her down.
Na Zdraví 87
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Has anyone heard of or tried Sam-E supplement? My brother had anxiety and was on prescription meds but takes this now and is off the RX meds.

Max Power
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Things were a little better this morning, not significantly, but better than the over an hour solid of crying yesterday. We still weren't able to get her to eat almost anything. My wife dropped her off at school this morning and had a similar situation that I did yesterday, full meltdown, not wanting to get out of the car. One of my wife's friends happened to be in line not far behind her and saw what happened. Monday we're going to take their daughter, who is a few years older, to school with ours. Hopefully that will help her be in a better mood, fingers crossed.
jczar03
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Max, I'm sorry to hear this about your precious daughter. It sounds like separation anxiety, but it may be separation anxiety from her Mom or her Dad or both. My daughter is 29 and her psychologist believes she is currently experiencing some separation anxiety. I remember suffering from this off and on when I was in elementary school. It's encouraging to hear she gets better during the day. Praying for all of you!
pinkdog
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https://www.nccih.nih.gov/health/sadenosyllmethionine-same-in-depth
jczar03
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I picked up my daughter from Menninger Clinic today. She is doing well and so happy to spend the weekend with us before joining Menninger's Pathfinder program on Monday morning which is essentially apartment living with a roommate and at least 3 counseling sessions per day and a lot of socializing with peers that will serve as a transition period back to some level of normalcy.

Through genetics testing, we found out that she was likely to suffer from anxiety and depression at some point in her life and that many anti-depression medications would not work for her. Unfortunately, she was prescribed a lot of these medications over the past 3 years. Hopefully this information about genetics testing may help someone in the future.

Thank you all for your prayers, thoughts and support over the past 2 months!
pinkdog
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Really glad to hear of your daughter's progress. Thanks for sharing and your story is already helpful to some of us going through similar things.
Max Power
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Thanks for the update, really happy to hear your daughter is making some progress. I hope that gives you some reprieve as a parent and the stress this has had on you and the rest of your family.
G. hirsutum Ag
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I'd like to encourage anyone struggling with chronic health issues, both mental and physical, to listen to my friends podcast. His primary audience is people who struggle with chronic illness that are under 40

https://podcasts.apple.com/us/podcast/chronic-life/id1624993276

And there is a Reddit group for similar discussion for those interested

https://www.reddit.com/r/HowAreUDoing/
G. hirsutum Ag
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That is great news. It takes so long to figure this stuff out sometimes. Keep working on it!
Lily09
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Interesting about the genetic testing. How did you go about doing that? Hope your daughter continues to get better.
jczar03
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I'm waiting on more specific information on the genetics testing, but it is either done through blood work or a cheek swab. For some reason it was not the easiest process. Not sure why there is so much hesitation in the medical field other than you might find out something about yourself that you may not want to know, but I told the doctors that we were only interested in results related to anxiety and depression.
pinkdog
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Hi jczar, I saw your post on another thread and decided to bump this one up. I do not want to derail a thread concerning your daughter but wanted to ask more about the genetics testing. Did they explain it to you? What will it show that indicates which antidepressant a person may need? Earlier you mentioned your daughter being on something to increase appetite and help with sleep. Can I ask what that was, if it helped? (Only if you feel like answering). I've tried requip and Lunesta for sleep but have had trouble with both.
jczar03
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Thanks for bumping, pinkdog. I'll certainly share more information as we receive it from the doctors. The communications around the genetics testing has been strange for some reason.
 
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