For three years I had an 80 series, then for five years I had a 100 series, and for over half a year now I've had a second gen Sequoia. For 7 of the 8 years I had Land Cruisers my wife drove a minivan (we have 3 kids and they were young) and I had daily driver cars, the SUV was for fun, hauling crap, sweaty kids or sweaty me - I bought them cheap with high mileage. With the kids older my wife eventually wanted out of the minivan and got a small car, so we spent a year with the 100 series as the family road trip car. It worked ok, but 3rd row was hard to get in and seat is 6" off the floor. Only kept one of the third rows seats in so for our trips we still had plenty of room to pack and even the beach trip stuff worked with a hitch rack - but not the biggest interior space for a family of five on longer trips. I had a lot of mods and repairs ame upgrades in the 100, it looked awesome IMO, but it was at 225k miles and getting long in the tooth. Plenty of life left but just little nagging age wear and teAr. Back in September I sold that 2006 100 for 19k and bought a 2012 Sequoia in great shape for 13k. It has four captains chairs so third row easy to get to. To maximize storage I fold down the double third row seat and leave single third row seat - which an adult could sit in much less a kid - up. It's got noticeably more power and acceleration than the 100. Gas mileage is still terrible but over 1 mpg better than 100. Tows better than the 100. I think it rides very well but do miss the hydraulic suspension on the 100 for sure. Miss the cool factor of the Land Cruiser. Not as many mods for a Sequoia and while not ugly the 100 series looks light years better to me. I did off-road in the Land Cruisers, but very rarely and to be honest the Sequoia could probably do everything I did in the Cruisers, I was not daring, provided it wasn't too wide. All in all, the Sequoia is a much better fit for the family at this moment.
If comparing to a 200 series then I would say price (not just purchase but gas and maintenance) is heavily in Sequoia's favor. Cool factor and looks in the 200's favor (imo, it's subjective). resale values good on all. build quality good on all. Sequoia is quite beefy but everything feels a bit more solid on the 200.
It all comes down to family use case, budget, and a lot of subjective preferences. I loved owning Land Cruisers, got attention and conversations from strangers that the Sequoia will never draw. But, I've been impressed with the Sequoia. Just got back from Big Bend this past weekend, family was comfortable, running 90 mph on I-10 or on dirt roads in Big Bend (but I did miss the AHC!)