DuncanAg said:
I posted this before but don't think anyone ever responded. I actually have my Pfizer 2nd dose scheduled for tomorrow which is actually day 18 post 1st. They gave me a scheduling window of 17-19 days after the 1st.
I know the EUA states there is a 4 day grace to remain valid. Just wondering if others are getting the 2nd dose not on the 21st day?
Most vaccines are approved to be given up to 4 days prior to scheduled due date. However most vaccines are also given a month apart or longer.
From what I remember, and from what I researched when I had to get people other vaccines in tight deadlines, you really want to separate the vaccines by at least enough time to get the initial antibody response to start dyeing down.
I haven't verified the info in these two graphs, and the first one seems a bit exaggerated, but basically a second challenge to the immune system, if too early, could potentially be neutralized by existing antibodies and not really pose enough of a challenge to the immune system to trigger the long term memory cells.
So, in short, to answer your question, if it was me, I'd rather go after 21 days than before. I am by no means an expert in this but I actually think 21 days is barely enough time to separate the vaccines. I'm pushing to day 24 as it's this Friday and because I don't want to be miserable at work during the week.
Perhaps our resident ID expert can chime in. Immunology was never my forte.