A revolver is an excellent choice for a first handgun for a variety of reasons. Regardless of what you buy, but especially if you go the semi-auto route right out of the gate, I would encourage you to spend some money on a handgun basics class for you and your wife.
And for whatever it's worth, I live in The Woodlands area of Houston and if you happen to be in this part of the world I'd be glad to meet you at a range and let you shoot as many of my guns as you'd like and share whatever knowledge I have.
The only downside for you is that I've all but standardized on Glocks for my handguns... I only own two handguns that aren't Glocks. So if a Glock is indeed out of the question there might not be much value there, but I'd be glad to give you some pointers as best I can regardless.
You may have picked up on some silly snippiness in this thread - gun owners, and particularly owners of Glocks, XDs and Sigs, are very brand loyal and we frequently kick each other in the nuts around here. Please don't take it personally.
I'm not an Ag but I hang around a lot on this forum because the Ags (and others) that loiter here are high quality folk. You'll get good advice here... even if you do something as foolish as buying a handgun that isn't a Glock.
[This message has been edited by Skubalon (edited 7/9/2014 11:12p).]