China Coronavirus Outbreak Spreads; Hundreds Infected As Human-To-Human Transmission

3,234,557 Views | 21764 Replies | Last: 2 mo ago by Stat Monitor Repairman
Joe Exotic
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rgag12 said:

Bo Darville said:

We've seen no proof that this virus is susceptible to warm or humid weather. Not all viruses are.


We haven't seen any evidence that it isn't. The fact that it's from the flu family indicates it's likely


Coronavirus and influenza viruses aren't even in the same phylum, much less the same family.
BQ_90
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law-apt-3g said:

HowdyTAMU said:

SoupNazi2001 said:

Really




Who would have thought to test a dog anyway?


The dog tester
or food tester.
HouAggie2007
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Facts don't have any place on the board
rgag12
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I didn't lay out any facts, I stated what I thought I knew.

I admit that I was wrong about it being an influenza strain. But I am not backing down from the fact that other viruses from this virus family behave similarly to the flu. Which is why many people believe it will die slow down in summer. That was the point I was trying to make. You and Bo both know this
Bobcat-Ag
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Thank you for correcting my misconception. I lumped in several viruses into the coronavirus family incorrectly. The common cold, MERS, and SARS are in the same family, but the Flu is different.
Joe Exotic
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Well, a cold can be caused by many different viruses including both influenza and coronaviruses. It's kind of just a catch all for any mild viral infecfion.
Big Al 1992
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Sid said:

https://www.cdc.gov/handwashing/show-me-the-science-hand-sanitizer.html
Here's the lowdown on hand sanitizers with plenty of footnotes to dig into.

Of course, this is put out by the CDC, so it's either reasonable advice or a plot of the Illuminati depending on your point of view.


Good to know when people are freaking out over H-E-B selling out of Purel, I can just walk 3 feet over and load up on bars of Irish Spring, Ivory and Lava soap!
Zobel
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Right, if the primary vector is droplet transmission colder and drier weather favors transmission. As temperature and humidity increase, the droplets are less stable - they get more water from the air, get larger, and fall.

On the other hand some viruses spread primarily by direct contact (handshakes, infected surfaces).

Transmission through the air is split between large droplets (coughs and sneezes) and small particles (simply by breathing - aerosols). Heat and humidity reduce both. Flu does all three (large droplet, aerosols, contact).

It's not clear even with the diseases we know well what the actual relative importance of each of these methods is. There's recent research that suggests aerosols are more important in Influenza A than we might have previously thought.

No one really knows for sure what the primary route is for this virus. The big SARS outbreak began a bit late in "flu season" and ended by March. It could well be that temperature was a big part of that.

Some of the earlier stuff was talking about a fecal oral route. :/
Joe Exotic
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rgag12 said:

I didn't lay out any facts, I stated what I thought I knew.

I admit that I was wrong about it being an influenza strain. But I am not backing down from the fact that other viruses from this virus family behave similarly to the flu. Which is why many people believe it will die slow down in summer. That was the point I was trying to make. You and Bo both know this

Warmer and humid weather can have a profound effect on viruses that have short incubations and survival times on exposed surfaces. The fear with this coronavirus is that its incubation and surface survival are unusually long, which negates many of the advantages of warmer weather (people in close proximity for longer durations, heat/humidity killing it faster on surfaces, etc). I hope warm weather kills it. But I don't think it's something we should count on as certain, since many viruses thrive in those conditions.
cisgenderedAggie
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Still not so sure I'd blindly extrapolate that way. First, if the numbers are to be believed, this seems a lot more contagious than previous coronaviruses. That alone should be reason enough for preparation and caution. Beyond that, why do respiratory viruses get suppressed in warmer weather? Is it because of some pathology with how the virus propagates (eg, reduced shedding because the temperature outside of the host got closer to the normal body temperature of its host) or is it related to changed behavior by the host (eg, less time inside enclosed spaces because it's not cold anymore)? You don't know anything about the former for this virus. The latter, combined with how infectious it appears should make you less confident that this just goes away because weather.
Rapier108
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The common cold is caused by rhinoviruses and coronaviruses, the former being the more common.

The flu/influenza is a different family of viruses.
"If you will not fight for right when you can easily win without blood shed; if you will not fight when your victory is sure and not too costly; you may come to the moment when you will have to fight with all the odds against you and only a precarious chance of survival. There may even be a worse case. You may have to fight when there is no hope of victory, because it is better to perish than to live as slaves." - Sir Winston Churchill
tysker
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Quote:

this seems a lot more contagious than previous coronaviruses
Is it more contagious or is it ust that we haven't (yet?) built up a natural immunity so its spreading faster than non-novel strains?
Joe Exotic
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Rapier108 said:

The common cold is caused by rhinoviruses and coronaviruses, the former being the more common.

The flu/influenza is a different family of viruses.

The cold can be caused by influenza virus and adenoviruses as well.
cisgenderedAggie
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Don't know, but does it matter right now? The outcome right now is the same.
Phat32
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Bo Darville said:

We've seen no proof that this virus is susceptible to warm or humid weather. Not all viruses are.
How's it doing in the southern hemisphere?
tysker
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For this initial spread probably not a lot but when it come around again it most definitely matters
Zobel
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About half of the "common cold" causes are coronaviruses of one kind or another, so not even flu-like. SARS was a coronavirus too, and apparently is fairly similar to this one.

I don't understand the incessant and constant comparison to the flu. Most of the comparisons to the flu aren't really specific to the flu but viral infections in general. Many of the initial symptoms of ebola are common with the flu (fever, aches and pains, fatigue). This presents with fever, dry cough, shortness of breath, sometimes diarrhea - but not typically runny nose or muscle aches like the flu.

It may well slow down in summer. I saw a guy - maybe that Fauci doctor - saying one probable outcome is that this becomes seasonal like the flu. Or it may mutate and become a minor nuisance like other coronaviruses that cause colds. But if the primary infection vector is more aerosols and less large droplets, the temperature and humidity changes in summer wont help as much. If it is more contact oriented than the flu, summer won't help as much. If a primary route is fecal-oral as was reported, summer won't help as much.

The only responsible thing to do right now is wait and see. Both hysteria and downplaying it are irresponsible. Don't compare it to the flu. It is not the flu. The closest comparison is SARS - and, as I mentioned, the SARS outbreak began in March and ended by May. Was that because of weather? Not sure.
Eric Forman
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k2aggie07 said:

Right, if the primary vector is droplet transmission colder and drier weather favors transmission. As temperature and humidity increase, the droplets are less stable - they get more water from the air, get larger, and fall.

On the other hand some viruses spread primarily by direct contact (handshakes, infected surfaces).

Transmission through the air is split between large droplets (coughs and sneezes) and small particles (simply by breathing - aerosols). Heat and humidity reduce both. Flu does all three (large droplet, aerosols, contact).

It's not clear even with the diseases we know well what the actual relative importance of each of these methods is. There's recent research that suggests aerosols are more important in Influenza A than we might have previously thought.

No one really knows for sure what the primary route is for this virus. The big SARS outbreak began a bit late in "flu season" and ended by March. It could well be that temperature was a big part of that.

Some of the earlier stuff was talking about a fecal oral route. :/


I read this as we're all going to eat **** and die.
scottimus
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tysker said:

Quote:

this seems a lot more contagious than previous coronaviruses
Is it more contagious or is it ust that we haven't (yet?) built up a natural immunity so its spreading faster than non-novel strains?

You guys need to go back and read at least the last 10-15 pages.

Can be 20x as contagious as the original Corona...SARS. The protein binding mechanism (similar to HIV) is why.
Quote:


Coronavirus up to 20 times more likely than Sars to bind to human cells, study suggests

https://www.scmp.com/news/china/society/article/3051124/coronavirus-20-times-more-likely-sars-bind-human-cells-study


The deadly new coronavirus is up to 20 times more likely to bind to human cell receptors and cause infection than severe acute respiratory syndrome (Sars), a new study by researchers at the University of Texas at Austin has found.


The novel coronavirus and Sars share the same functional host-cell receptor, called angiotensin-converting enzyme 2 (ACE2).

The report, published on the website bioRxiv on Saturday, said the new coronavirus had around 10 to 20-fold higher affinity the degree to which a substance tends to combine with another for human ACE2 compared with Sars.

But the researchers added that further studies were needed to explore the human host-cell receptor's role in helping the new virus to spread from person to person.

The new study found that although the novel coronavirus' receptor-binding domain (RBD) had a relatively similar structure to that of Sars, it did not have appreciable binding to three published Sars RBD-specific monoclonal antibodies (mAbs), which are copies of one type of antibody used to neutralise pathogens.

Zobel
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No one really knows. It could also seem to be more contagious because people simply weren't practicing normal habits that they might if something is going around. The spread was way worse in Hubei than outside in the rest of China.

On the other hand, it does seem to get a foothold quickly. The "how contagious is it" is kind of difficult, because the net result we observe isn't - if I put one virus in your nose, what are the odds you get sick. It's a combination of that plus how long people have asymptomatic transmission, how long the incubation period is, and how its transmission combines with people's habits and environments.
cisgenderedAggie
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Perhaps, but unless this virus is humanity's endgame, I still don't think it matters much. The economic damage is going to be most problematic now, when we aren't used to it, and I think that's the biggest problem with the whole thing.
AgFan2015
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TurkeyBaconLeg said:

Bo Darville said:

We've seen no proof that this virus is susceptible to warm or humid weather. Not all viruses are.
The proof as I understand it is because this is a respiratory disease and how it is transmitted. Warmer weather tends to slow down these types of illnesses. Like the flu...


Can y'all please use some common sense when discussing this "summer time" fallacy?

- The average American spends 90% of their time INDOORS.
- This virus is easily spread via aerosol particulates
- It has an R0 value somewhere in the 3 to 6 range
- It stays infectious on surfaces anywhere from hours to 9 days
- it's infectious during the asymptotic phase
- it's easily spread person to person.

Meaning the places you visit regularly ( ie: grocery stores, schools, offices, restaurants, gyms, airplanes, concerts, sporting events, etc ) are potential sources of infection regardless of what the weather is outside.


The warmer weather has three things going for it
- the extended hours of UV sunlight to disinfect outdoor surfaces
- the sunlight helps boost the human immune system (but only if you actually spend time, you know, outdoors)
- some people spend a little less time indoors however the vast majority will tend to shelter inside when the temps reach over 95 consistently in Texas.


It's not going away or even slow down much simply because the weather changed.
tysker
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I'm sure I'm not alone in saying that I dont really have a clue what any of that really means.
Maverick06
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Have a family cruise set to embark from Galveston March 8 visiting Mexico and Belize. I'm having serious doubts on whether to go or cancel and lose the payments. I think Carnivals response is piss poor in that they are only screening passengers that have recently traveled from China, Hong Kong or Macau. Meanwhile this thing is global. Thoughts?
scottimus
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tysker said:

I'm sure I'm not alone in saying that I dont really have a clue what any of that really means.
Fair enough.

Short synopsis.
  • It is more contagious.
  • There is no herd/natural immunity.
  • Possibly takes over cells like HIV.
Zobel
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Anecdotal evidence. My company (15,500 global employees in 50 countries) has an internal COVID-19 page up.

You can read some stuff here:
https://pandemic.internationalsos.com/2019-ncov/ncov-travel-restrictions-flight-operations-and-screening

We had our first employee get sick. Someone who worked in Sweden and vacationing in Northern Italy.
RAB91
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Maverick06 said:

Have a family cruise set to embark from Galveston March 8 visiting Mexico and Belize. I'm having serious doubts on whether to go or cancel and lose the payments. I think Carnivals response is piss poor in that they are only screening passengers that have recently traveled from China, Hong Kong or Macau. Meanwhile this thing is global. Thoughts?
I wouldn't do an Asian or European cruise, but I'd go on one out of Galveston.
scottimus
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Mexico just confirmed their first 2 corona virus positives.

I don't know how many cruise ships are out in the world, but...from what we have seen I don't know if that would be a good idea to go on right now?

That being said, I have no experience in cruises.
tysker
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k2aggie07 said:

No one really knows. It could also seem to be more contagious because people simply weren't practicing normal habits that they might if something is going around. The spread was way worse in Hubei than outside in the rest of China.

On the other hand, it does seem to get a foothold quickly. The "how contagious is it" is kind of difficult, because the net result we observe isn't - if I put one virus in your nose, what are the odds you get sick. It's a combination of that plus how long people have asymptomatic transmission, how long the incubation period is, and how its transmission combines with people's habits and environments.
Which is why it seems slightly disingenuous to say this one is "more contagious." It may be true but its not certain until we get a better understanding and, unfortunately, more people are infected.

We don't have a natural immune response at this time so when this version gets its quicker foothold, we also don't have a way to naturally stop to spread, so its a double whammy. At least until humans worldwide build up a more immunity individually and community-wide.

If I'm understanding this all wrong feel free to correct...
Eric Forman
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So these companies that claim they'll have a vaccine here in a few weeks... are those DNA immunizations or conventional vaccines? If conventional, and assuming the virus behaves and mutates like HIV, how will the vaccine actually be helpful?
txaggie_08
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Maverick06 said:

Have a family cruise set to embark from Galveston March 8 visiting Mexico and Belize. I'm having serious doubts on whether to go or cancel and lose the payments. I think Carnivals response is piss poor in that they are only screening passengers that have recently traveled from China, Hong Kong or Macau. Meanwhile this thing is global. Thoughts?

Not sure I'd go. You risk getting stuck on that ship for quite a while. Look at the ships that are being denied entry because of passengers showing symptoms. Hopefully a ship originating from the US wouldn't have the same issues getting back, but who knows.

But I hate cruises to begin with, so my advice may be prejudiced.
Joe Exotic
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yukmonkey said:

Bo Darville said:

We've seen no proof that this virus is susceptible to warm or humid weather. Not all viruses are.
How's it doing in the southern hemisphere?

We don't know yet.
Shanked Punt
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Maverick06 said:

Have a family cruise set to embark from Galveston March 8 visiting Mexico and Belize. I'm having serious doubts on whether to go or cancel and lose the payments. I think Carnivals response is piss poor in that they are only screening passengers that have recently traveled from China, Hong Kong or Macau. Meanwhile this thing is global. Thoughts?
That's still early enough before things would really blow up here if they ever do. A cruise in April - May may be a different story.
Zobel
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Epidemiologists who study this kind of thing have estimated the R0 to be 3-6. Seasonal flu is 1-2. So while we don't really know, it seems worse.

From our company internal page, thought this was useful and reasonable:


Quote:

The article assumes that that a pandemic will occur at some point and that Wave 1 will impact us, wherever we live, in the coming weeks and months. We don't know how severe a COVID-19 pandemic will be. We won't know for sure until we see spread in other countries that document the spread and the illness. It takes two scenarios from the Australian Health Management Plan for Pandemic Influenza.

Scenario one: clinical severity is low
The majority of cases are likely to experience mild to moderate clinical features. People in at-risk groups may experience more severe illness. Strategies to support at-risk groups may be required (e.g. aged care, infants, remote communities). At the peak of the pandemic, and increasingly when transmissibility is higher, primary care and hospital services are likely to be stretched to coping capacity in areas associated with respiratory illness and acute care. The level of impact on the community may be similar to severe seasonal influenza or the 2009 H1N1 pandemic.

Scenario two: clinical severity is moderate
Young healthy people and people in at-risk groups may experience severe illness. The number of people presenting for medical care is likely to be higher than for severe seasonal influenza and primary care and hospital services will be under severe pressure, particularly in areas associated with respiratory illness and acute care. Non-urgent procedures and activities will need to be scaled back. Surge staffing and alternate models of clinical care, such as flu clinics may need to be employed to cope with increased demands for healthcare. Pressure on health services will be more intense, rise more quickly and peak earlier as the transmissibility of the disease increases. Healthcare staff may themselves be ill or have to care for ill family members, further exacerbating pressures on healthcare providers.
DVC2010
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TexasAggie_02 said:

BowSowy said:

Nuclear Scramjet said:

BowSowy said:

Nuclear Scramjet said:

Tx-Ag2010 said:

Nuclear Scramjet said:

Tx-Ag2010 said:

Why do people keep saying hand sanitizer is useless... I'm sure it's not quite as effective as dunking your hands in boiling soapy water for 60 seconds but from what I understand it still kills viruses.


Hand sanitizer is less effective than a 5 second hand rub with just water. It is that useless.


Do you have a link? Is that for soiled hands or mostly clean hands? This just seems counter intuitive.


Any first aid class will tell you this and do an experiment. What removes disease is friction combined with soap. They even did a test with a benign bacteria. 20 second soap scrub, 5 second water rinse and scrub, hand sanitizer, and nothing. The results always were 20 second scrub was by the best, then the water rinse, then hand sanitizer, and then nothing. Hand sanitizer is slightly better than doing nothing but your hands will still be covered after using it.
But hand sanitizer is good for situations where you can't wash. You're right that it shouldn't be used to replace hand washing, but those who are saying it's "useless" are off base as well


When I say it was better than nothing, the difference was almost negligible. You're better off taking a water bottle and then scrubbing your hands with slowly pouring it over them. Hand sanitizer by itself does almost nothing. The whole thing is a scam. The black light showing how much bacteria was left proved it's practically worthless.
This just doesn't jive with me. Do you have some sort of source other than your own anecdotal experience? I have my own anecdotal evidence that is counter to what you're talking about so I'd like to see some sort of source saying hand sanitizer use is basically no better than doing nothing.
https://msphere.asm.org/content/4/5/e00474-19

AHR = Antiseptic Hand Rubbing (hand sanitizer)

AHW = Antiseptic Hand Washing (plain water, no soap)

IAV = Influenza A Virus

EBD = Ethanol Based Disinfectant

Quote:

The clinical analysis showed that although IAV in saline was completely inactivated by AHR using EBD within 30 s, IAV in all mucus samples remained active, even after AHR for 120 s, and was completely inactivated by AHR within 240 s. The log reduction of IAV in mucus was significantly lower than that in saline after AHR for 30, 60, and 120 s (i.e., the IAV survival ratio in mucus was significantly higher than that in saline). The efficacy of AHR was also examined after allowing the saline and mucus samples to dry completely after placing them on the fingers. IAV was inactivated rapidly by AHR within 30 s in both dried mucus samples and dried saline. Furthermore, IAV was inactivated rapidly by AHW within 30 s under all conditions (in both undried and dried mucus samples and undried and dried saline
Quote:

First, regarding the AHW regimens in this study, handwashing was practiced using running water only, without using plain or antiseptic soap. These AHW regimens were expected to have a lower pathogen inactivation effect compared to that of AHW regimens using plain or antiseptic soap. However, IAV on the fingers was completely inactivated within 30 s under all AHW conditions, showing a good IAV inactivation effect of AHW in this study.


TLDR: Ethanol works in 30s seconds on flu in saline. But in mucus, it can take 2-4 mins. Washing hands with nothing but water worked in 30 seconds in saline or mucus.

But once the mucus is dried, it no longer protects the virus. So if someone sneezes on your hands, definitely go wash them right now. If you pick up the virus from a doorknob, hand sanitizer is very effective.
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