What kind of sound are you going for?
For the last year or so, my primary tone stack is
Tele or Strat -> Vahlbrach Kaluna -->Imperial MKii Lead Channel at 5 on Volume, 6 on Tone, and 4 on mid bite.
My Tone King setting gets me that great edge of breakup tone for good clean stuff but with a bit of a tweed-like character. Then I use the Kaluna to push the front of the amp to get a more marshally driven sound. On the Kaluna, I roll back the bass a lot, roll a bit off the mids, and push the highs.
This setup has been tone heaven for me. I get the exact character I want with my fully driven sound, and backing off the volume on my guitars clean up extremely well.
I say all that to say: I would really look into the various pre-amp pedals on the market. They are especially great at driving a single channel amp and getting creamy gain at lower volumes because the pedals usually are designed to drive their single tube at a high level.
For my humbucker pickups, I use my Kingsley Page TS pedal instead of the Kaluna because the character of that one works better for humbuckers, imo.
Also, are you looking for a combo or a head? With either one, do you know if you prefer opened or closed back speakers?