Natural immunity and vaccines

2,824 Views | 26 Replies | Last: 3 yr ago by aTm2004
KidDoc
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AG
Found this really nice summary from CNET (no paywall) for those interested in the current data on risk of re-infection and how vaccines relate to wild immunity.

Coronavirus reinfection: What we know about immunity from having COVID and whether you can get it twice (msn.com)
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
Gordo14
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KidDoc said:

Found this really nice summary from CNET (no paywall) for those interested in the current data on risk of re-infection and how vaccines relate to wild immunity.

Coronavirus reinfection: What we know about immunity from having COVID and whether you can get it twice (msn.com)


Basically confirming the "messaging" that has been said all along. Natural immunity is good. Vaccine is better. Immunity is better than no immunity. Therefore vaccine before a person catches COVID should be the goal. Cue rant about Fauci, the MSM media, and masks.
The_Fox
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Had the rona before the vaccine was available. My functioning immune system handled it just fine. It was like mild allergies.

Now that the vaccine is available, why get it? My functioning immune system handled it fine before and now I have natural immunity plus a functioning immune system.

Concerns over COVId need to end. It's past time to function normally again and let the chips fall where they may.
ttha_aggie_09
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AG
Thanks for sharing! Pretty consistent with everything that's been released so far.

Quote:

Another factor that might lead to underreported reinfection cases is that many second instances of COVID-19 are mild, which leads people to not realize they're infected again, virologist Theodora Hatziioannou told Healthline.


This part is also very consistent with the other studies. A lot of concern about the data being skewed because of a positive test months after initial infection
Quote:

Not necessarily, especially if you're testing within three months of first getting sick, according to Weissenbach. If someone tests positive for COVID-19, tests negative and then tests positive again, it's likely due to viral shedding of the original virus, he says.

"Many viruses can shed for quite some time after the illness has subsided," Weissenbach says. True reinfection with COVID-19 means that someone was infected with the virus on two different occasions, usually months apart. Long COVID-19, a syndrome that some people develop after having the coronavirus, is also not a reinfection or active infection.
Old Buffalo
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It's also based off the flawed Kentucky "study".


Quote:

this was not cohorted or randomized. it was not even prospective. they picked a bunch of people who had had covid and then tested positive for covid again out of a database. there was no symptomatic confirm or any other validation. we have no idea if they were even clinically sick, and most probably were not.


control were just "people who had covid and then were not re-infected." they picked this group out of a hat. there's no matching for comorbidities etc that played such a massive role here and those that had them were more likely to get re-infected because that maps to weak immune systems. the selection bias on that alone almost certainly invalidates any study claims.

they then back screened for vaccination status.

this is a garbage methodology so riddled with confounds as to render a result this minor moot, especially in an N this small (240 cases vs 492 control). (less than 1/10th of 1% of all previous cases were re-infected. this is well within even just the error on the test.)



https://boriquagato.substack.com/p/vaccinating-the-recovered?token=eyJ1c2VyX2lkIjo0MzAyMTc1MCwicG9zdF9pZCI6NDAwMjM5NjAsIl8iOiJCZTVQZyIsImlhdCI6MTYzMTgzODAyNywiZXhwIjoxNjMxODQxNjI3LCJpc3MiOiJwdWItMzIzOTE0Iiwic3ViIjoicG9zdC1yZWFjdGlvbiJ9.eSFdzTs4PMIsNPc9tDX1EVpaN8DQGfIQ1gb0g6jXE-E
“The Party told you to reject the evidence of your eyes and ears. It was their final, most essential command.”
St Hedwig Aggie
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AG
The_Fox said:

Had the rona before the vaccine was available. My functioning immune system handled it just fine. It was like mild allergies.

Now that the vaccine is available, why get it? My functioning immune system handled it fine before and now I have natural immunity plus a functioning immune system.

Concerns over COVId need to end. It's past time to function normally again and let the chips fall where they may.

The beauty of choice for you. Don't want to get it because you feel it is unnecessary for you? …that's your call! Best wishes going forward!
Make Mental Asylums Great Again!
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Wakesurfer817
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https://texags.com/forums/84/topics/3215580

Functioning immune systems here.
The_Fox
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Wakesurfer817 said:

https://texags.com/forums/84/topics/3215580

Functioning immune systems here.
Apparently, not as well functioning as mine.
traxter
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SoupNazi2001 said:

Gordo14 said:

KidDoc said:

Found this really nice summary from CNET (no paywall) for those interested in the current data on risk of re-infection and how vaccines relate to wild immunity.

Coronavirus reinfection: What we know about immunity from having COVID and whether you can get it twice (msn.com)


Basically confirming the "messaging" that has been said all along. Natural immunity is good. Vaccine is better. Immunity is better than no immunity. Therefore vaccine before a person catches COVID should be the goal. Cue rant about Fauci, the MSM media, and masks.


Lol that you think the vaccine is better than natural immunity. Plenty of studies prove that is false.
Vaccine is better for the shear reason that you don't actually get COVID and all the potential complications that come with, plus you don't spread it to others. If you have natural immunity, that's great, although we know that level of natural immunity will vary substantially based on severity of infection. Also, natural immunity + vaccine is the best according to all the data I've seen.
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Wakesurfer817
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The_Fox said:

Wakesurfer817 said:

https://texags.com/forums/84/topics/3215580

Functioning immune systems here.
Apparently, not as well functioning as mine.
As long as we agree it's not binary.
TelcoAg
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AG
The_Fox said:

Had the rona before the vaccine was available. My functioning immune system handled it just fine. It was like mild allergies.

Now that the vaccine is available, why get it? My functioning immune system handled it fine before and now I have natural immunity plus a functioning immune system.

Concerns over COVId need to end. It's past time to function normally again and let the chips fall where they may.


Natural immunity is great! But the coolest new data coming out is how folks who made it through infection that are getting vaccinated are seeing their immune systems create broader defenses against both existing variants and theorized ones.

But you do you brother
gunan01
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AG
Maybe read the article?
gunan01
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SoupNazi2001 said:

Gordo14 said:

KidDoc said:

Found this really nice summary from CNET (no paywall) for those interested in the current data on risk of re-infection and how vaccines relate to wild immunity.

Coronavirus reinfection: What we know about immunity from having COVID and whether you can get it twice (msn.com)


Basically confirming the "messaging" that has been said all along. Natural immunity is good. Vaccine is better. Immunity is better than no immunity. Therefore vaccine before a person catches COVID should be the goal. Cue rant about Fauci, the MSM media, and masks.


Lol that you think the vaccine is better than natural immunity. Plenty of studies prove that is false.
This incorrect line has been parroted out there for awhile now. It's pretty clear that immunity from wild-type infection is unpredictable, whereas vaccine immunity on average is better and more predictable.
snowdog90
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gunan01 said:

SoupNazi2001 said:

Gordo14 said:

KidDoc said:

Found this really nice summary from CNET (no paywall) for those interested in the current data on risk of re-infection and how vaccines relate to wild immunity.

Coronavirus reinfection: What we know about immunity from having COVID and whether you can get it twice (msn.com)


Basically confirming the "messaging" that has been said all along. Natural immunity is good. Vaccine is better. Immunity is better than no immunity. Therefore vaccine before a person catches COVID should be the goal. Cue rant about Fauci, the MSM media, and masks.


Lol that you think the vaccine is better than natural immunity. Plenty of studies prove that is false.
This incorrect line has been parroted out there for awhile now. It's pretty clear that immunity from wild-type infection is unpredictable, whereas vaccine immunity on average is better and more predictable.


This is insanity.
Get Off My Lawn
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traxter said:

SoupNazi2001 said:

Gordo14 said:

KidDoc said:

Found this really nice summary from CNET (no paywall) for those interested in the current data on risk of re-infection and how vaccines relate to wild immunity.

Coronavirus reinfection: What we know about immunity from having COVID and whether you can get it twice (msn.com)


Basically confirming the "messaging" that has been said all along. Natural immunity is good. Vaccine is better. Immunity is better than no immunity. Therefore vaccine before a person catches COVID should be the goal. Cue rant about Fauci, the MSM media, and masks.


Lol that you think the vaccine is better than natural immunity. Plenty of studies prove that is false.
Vaccine is better for the shear reason that you don't actually get COVID and all the potential complications that come with, plus you don't spread it to others. If you have natural immunity, that's great, although we know that level of natural immunity will vary substantially based on severity of infection. Also, natural immunity + vaccine is the best according to all the data I've seen.
Wait - hasn't this part been proven false? Breakthrough Delta is an obvious issue right now - with many hosting / passing the virus without realizing it.

I'm not arguing against acquiring immunity via the lowest risk option available (any immunity that eliminates the "novel" is going to help the immune system and a low risk first encounter in the form of a vaccine is a great option)...

But many folks who got vaccinated are still getting Delta and spreading it - often asymptomatically, which is great for them but may functionally result in wider dissemination than a counterpart who's symptomatic & self-quarantines.
KidDoc
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Get Off My Lawn said:

traxter said:

SoupNazi2001 said:

Gordo14 said:

KidDoc said:

Found this really nice summary from CNET (no paywall) for those interested in the current data on risk of re-infection and how vaccines relate to wild immunity.

Coronavirus reinfection: What we know about immunity from having COVID and whether you can get it twice (msn.com)


Basically confirming the "messaging" that has been said all along. Natural immunity is good. Vaccine is better. Immunity is better than no immunity. Therefore vaccine before a person catches COVID should be the goal. Cue rant about Fauci, the MSM media, and masks.


Lol that you think the vaccine is better than natural immunity. Plenty of studies prove that is false.
Vaccine is better for the shear reason that you don't actually get COVID and all the potential complications that come with, plus you don't spread it to others. If you have natural immunity, that's great, although we know that level of natural immunity will vary substantially based on severity of infection. Also, natural immunity + vaccine is the best according to all the data I've seen.
Wait - hasn't this part been proven false? Breakthrough Delta is an obvious issue right now - with many hosting / passing the virus without realizing it.

I'm not arguing against acquiring immunity via the lowest risk option available (any immunity that eliminates the "novel" is going to help the immune system and a low risk first encounter in the form of a vaccine is a great option)...

But many folks who got vaccinated are still getting Delta and spreading it - often asymptomatically, which is great for them but may functionally result in wider dissemination than a counterpart who's symptomatic & self-quarantines.
A large percent of break through infections are with Pfizer & J&J vaccines which is why there is so much booster chatter right now. Moderna seems to be holding up ok so far although and article came out yesterday showing some decline after 13 months in the original phase 3 study cohort.

No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
billydean05
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Vaccine people not spreading to others has been disproven through multiple studies and acknowledged by the CDC. At this point that should not be parroted on the COVID board and is blatant spread of misinformation.
TarponChaser
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ttha_aggie_09 said:

Thanks for sharing! Pretty consistent with everything that's been released so far.

Quote:

Another factor that might lead to underreported reinfection cases is that many second instances of COVID-19 are mild, which leads people to not realize they're infected again, virologist Theodora Hatziioannou told Healthline.


This part is also very consistent with the other studies. A lot of concern about the data being skewed because of a positive test months after initial infection
Quote:

Not necessarily, especially if you're testing within three months of first getting sick, according to Weissenbach. If someone tests positive for COVID-19, tests negative and then tests positive again, it's likely due to viral shedding of the original virus, he says.

"Many viruses can shed for quite some time after the illness has subsided," Weissenbach says. True reinfection with COVID-19 means that someone was infected with the virus on two different occasions, usually months apart. Long COVID-19, a syndrome that some people develop after having the coronavirus, is also not a reinfection or active infection.


Kinda like the breakthrough cases in the vaccinated?
ttha_aggie_09
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Yes - appears to be very similar. Although anecdotally, I don't know anyone that has had a confirmed case of symptomatic reinfection. I do know several with symptomatic breakthrough cases.
Get Off My Lawn
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Legitimate question: how does a booster reduce Delta breakthrough?

I get the idea of "increasing durability."
I get the idea that more vaccine exposure = reducing severity.
I get that more opportunities = fewer folks who slip through the cracks.

What doesn't make sense to me is how a virus that's getting around a vaccine is going to be stopped by taking more of that vaccine.
GeographyAg
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ttha_aggie_09 said:

Yes - appears to be very similar. Although anecdotally, I don't know anyone that has had a confirmed case of symptomatic reinfection. I do know several with symptomatic breakthrough cases.
I do. I know of one whose case was much worse the second time (lady who is a member of our church). Both times she took the test, both times recovered, several months apart.

She believes the first time was Alpha, second time must have been Delta. More of her family had it the second time (all but one kid and her husband, who got pretty sick but not hospitalized). She's skinny, late 30s, and very healthy otherwise.

She's over it now, but she's a confirmed reinfection with symptoms worse than the first time.

If I’m posting, it’s actually Mrs GeographyAg.
Mr. GeographyAg is a dedicated lurker.
ShinerDunk93
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Thank you KidDoc for posting.

So I read through the article that I thought was well written, and clicked through to the CDC study and I was not impressed. The study never actually discussed what the odds of a "break through" occuring was. I just stated that the odds are 2-3 times higher...........If the odds are .5% then the Natural vs Vaccine are effectively the same. They also point out several potential issues of the data gathering right at the end of the study. Using this study as a guide post is pretty weak sauce.

I'm not saying you shouldn't get vaxed or that natural is better/worse/equal than the vaccines. It seems like for the C19 Recovered, that there is a lot of "everybody get vaxed" because that is the only thing the govt can track messaging. It doesn't seem to do any significantly measurable harm and there is evidence that it is beneficial. I still can understand why low risk, recovered individuals wouldn't want to get the vaccine.

The analysis of El Gato Malo that is linked by Old Buffalo is not very flattering to say the least.. I've followed Malo's work and he is not a anti-vax person, he just expects the data and analysis to be more thorough and complete. There seems to be much better studies than the Kentucky one. This is one of the problems I have with the CDC.

FYI, I am pro-vaccine. I'm vaxed and so is my wife.
ttha_aggie_09
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AG
Glad she is okay!

Like I said, I don't know anyone that has had a confirmed reinfection case but it does occur. Fortunately those occurrences remain minuscule.
KidDoc
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Get Off My Lawn said:

Legitimate question: how does a booster reduce Delta breakthrough?

I get the idea of "increasing durability."
I get the idea that more vaccine exposure = reducing severity.
I get that more opportunities = fewer folks who slip through the cracks.

What doesn't make sense to me is how a virus that's getting around a vaccine is going to be stopped by taking more of that vaccine.
Mostly due to looking at the current data for Pfizer vs Moderna. Moderna has higher durability with Spike Tier antibodies and they have a lower risk of breakthrough infection. When blood is tested after a 3rd dose of Pfizer there is a nice rise in the antibodies which is clinically correlated with a lower risk of break through infection.

It actually does make sense. It is just discouraging how quickly Pfizer's protection has dropped. As mentioned the same may be happening with Moderna after 12 months from the smaller phase 3 patients.

There is hope that the delayed 3rd dose (at least 6 months after) will give durable protection for at least 5 years as that is how nearly every other vaccine ever works but only time will tell.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
Get Off My Lawn
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Thanks for the explanation. I guess I struggle with how subsequent doses would create leaps in benefit versus incremental (and diminishing) improvements, but I haven't studied biology in depth and know that my initial intuition has failed me before.
aTm2004
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AG
West Point Aggie said:

The_Fox said:

Had the rona before the vaccine was available. My functioning immune system handled it just fine. It was like mild allergies.

Now that the vaccine is available, why get it? My functioning immune system handled it fine before and now I have natural immunity plus a functioning immune system.

Concerns over COVId need to end. It's past time to function normally again and let the chips fall where they may.

The beauty of choice for you. Don't want to get it because you feel it is unnecessary for you? …that's your call! Best wishes going forward!
Actually, the government is taking that choice away from many people by threatening their jobs or making them get an unnecessary weekly test.
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