Interesting stuff. Has been submitted for publishing but has not been peer reviewed. Read the preliminary report here: https://www.biorxiv.org/content/10.1101/2020.03.22.002386v1.full.pdf+html (to read the report click "Preview .pdf" after the page loads).
24 of these are already FDA approved for other things. List includes Indomethacin, Valproic Acid, Haldol, chloroquine, and many others including at least one already approved anti-viral (Ribavirin). It obviously does not mean these would necessarily be effective treatment options as the study was designed to identify known compounds that could *potentially* disrupt viral interaction with host based on their structure and known mechanisms of action, but it's a good starting point.
They specifically point out there's a clear mechanism of action for both chloroquine and azithromycin.
Quote:
...we cloned, tagged and expressed 26 of the 29 viral proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), which identified 332 high confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 existing FDA-approved drugs, drugs in clinical trials and/or preclinical compounds, that we are currently evaluating for efficacy in live SARS-CoV-2 infection assays.
24 of these are already FDA approved for other things. List includes Indomethacin, Valproic Acid, Haldol, chloroquine, and many others including at least one already approved anti-viral (Ribavirin). It obviously does not mean these would necessarily be effective treatment options as the study was designed to identify known compounds that could *potentially* disrupt viral interaction with host based on their structure and known mechanisms of action, but it's a good starting point.
They specifically point out there's a clear mechanism of action for both chloroquine and azithromycin.
