Has anyone else on this forum been following this?

Kirin Holdings in Japan and others are on to something. See journal article citations below the presser in support of their functional foods they rolled out in the spring

Beta Lactolin (discovered in 2014) is obtained through artificial enzymatic digestion of Beta Lactoglobulin in whey products; or, by fermentation of cheeses (e.g. Cmembert) by Penicillium - usual process.... Beta lactoglobulin is a constituent of milk.

Japan already has functional foods containing Beta Lactolin rolled out in spring 2021 (see Kirin Holdings presser below).

[url=https://www.en-sjgle.com/news/show-21192.html][/url]https://www.en-sjgle.com/news/show-21192.html

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Kirin Holdings' beta-lactolin targets Japan's "super-aged" society with memory-supporting F&B
2021-03-04 foodingredientsfirst

Beta-lactolin, Kirin Holdings' new functional ingredient, is launching in a beverage, yogurt and supplements in Japan this spring to "support the maintenance of memory, which declines with age."

It targets those who are healthy, but have started to become forgetful or slower in making decisions due to the natural aging process.

"Beta-lactolin is distinct compared to other ingredients in that it works directly on cognitive function by increasing the neurotransmitter dopamine," Kozue Takayoshi, assistant manager of corporate communication at Kirin Holdings, tells NutritionInsight.

Applications for food
Kirin Holdings is working with several partners to launch new functional products containing the company's proprietary ingredient.

New products to be released throughout Japan include beta-lactolin by Kyowa Hakko Bio on April 20 and a Kirin beta-lactolin beverage by Kirin Beverage Company on May 11.

Koiwai Beta-lactolin Milk, a dairy-based drink from Koiwai Dairy Products Company will be released in select areas on May 18. Lastly, Megmilk Snow Brand is collaborating with Kirin to release a Kiokukea Yogurt lactolin in Japan on June 8.

A new ingredient for healthy agers
The milk-derived bioactive peptide beta-lactolin is positioned to address Japan's large aging population.

The whey protein-derived peptide is "a world first" for its specific mechanism of action, which increases the neurotransmitter dopamine, explains Takayoshi.

"The increase in dopamine stimulates neuronal activity in the prefrontal cortex and hippocampus, the brain regions responsible for memory."

"Through this mechanism, beta-lactolin helps people retain their capacity for memory," she adds.

Science of the ingredient
Beta-lactolin was first discovered in 2014 during Kirin Holdings' research on camembert cheese with the University of Tokyo and Koiwai Dairy, explains Takayoshi.

Kirin focused on epidemiological studies that showed daily consumption of dairy products is beneficial for retaining memory capacity and other cognitive functions.

Through this research, Kirin discovered the effect of milk-derived beta-lactolin on the maintenance of brain cognitive function.

Four years after the discovery of the peptide, a paper documenting its dopamine-promoting effects in mice was published.

Kirin then applied its expertise in fermentation to develop an ingredient that makes it easy to efficiently consume [sic - I think they mean "produce" not consume?] beta-lactolin.

Healthy aging on the rise
Japan's average life expectancy continues to increase, and the country has entered a "super-aged" society in which one in four people is elderly, notes the company.

Given that an estimated one in five elderly people will suffer from dementia in 2025, healthy aging is a social issue. ....

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Items 1-5 of 5 (Display the 5 citations in PubMed)
1.
-Lactolin Reduces Age-Related Inflammation and Cognitive Decline.
Ano Y, Ohya R, Takashima A, Uchida K, Nakayama H.
Front Nutr. 2021 Aug 23;8:724134. doi: 10.3389/fnut.2021.724134. eCollection 2021.
PMID: 34497823 Free PMC article.
2.
-Lactolin Enhances Neural Activity, Indicated by Event-Related P300 Amplitude, in Healthy Adults: A Randomized Controlled Trial.
Kanatome A, Ano Y, Shinagawa K, Ide Y, Shibata M, Umeda S.
J Alzheimers Dis. 2021;81(2):787-796. doi: 10.3233/JAD-201413.
PMID: 33814437 Free PMC article. Clinical Trial.
3.
-lactolin increases cerebral blood flow in dorsolateral prefrontal cortex in healthy adults: a randomized controlled trial.
Ano Y, Kobayashi K, Hanyuda M, Kawashima R.
Aging (Albany NY). 2020 Sep 29;12(18):18660-18675. doi: 10.18632/aging.103951. Online ahead of print.
PMID: 32989176 Free PMC article.
4.
-Lactolin, a Whey-Derived Lacto-Tetrapeptide, Prevents Alzheimer's Disease Pathologies and Cognitive Decline.
Ano Y, Ohya R, Takaichi Y, Washinuma T, Uchida K, Takashima A, Nakayama H.
J Alzheimers Dis. 2020;73(4):1331-1342. doi: 10.3233/JAD-190997.
PMID: 31929163 Free PMC article.
5.
-lactolin, a whey-derived glycine-threonine-tryptophan-tyrosine lactotetrapeptide, improves prefrontal cortex-associated reversal learning in mice.
Ayabe T, Ohya R, Ano Y.
Biosci Biotechnol Biochem. 2020 May;84(5):1039-1046. doi: 10.1080/09168451.2020.1714424. Epub 2020 Jan 11.
PMID: 31928148
Items 1-6 of 6 (Display the 6 citations in PubMed)
1.
Preventive Effects of Tryptophan-Methionine Dipeptide on Neural Inflammation and Alzheimer's Pathology.
Ano Y, Yoshino Y, Uchida K, Nakayama H.
Int J Mol Sci. 2019 Jun 29;20(13):3206. doi: 10.3390/ijms20133206.
PMID: 31261895 Free PMC article.
2.
Tryptophan-related dipeptides in fermented dairy products suppress microglial activation and prevent cognitive decline.
Ano Y, Yoshino Y, Kutsukake T, Ohya R, ***uda T, Uchida K, Takashima A, Nakayama H.
Aging (Albany NY). 2019 May 23;11(10):2949-2967. doi: 10.18632/aging.101909.
PMID: 31121563 Free PMC article.
3.
Novel lactopeptides in fermented dairy products improve memory function and cognitive decline.
Ano Y, Ayabe T, Kutsukake T, Ohya R, Takaichi Y, Uchida S, Yamada K, Uchida K, Takashima A, Nakayama H.
Neurobiol Aging. 2018 Dec;72:23-31. doi: 10.1016/j.neurobiolaging.2018.07.016. Epub 2018 Aug 6.
PMID: 30176402
4.
Preventive Effects of Dairy Products on Dementia and the Underlying Mechanisms.
Ano Y, Nakayama H.
Int J Mol Sci. 2018 Jun 30;19(7):1927. doi: 10.3390/ijms19071927.
PMID: 29966358 Free PMC article. Review.
5.
Preventive effects of a fermented dairy product against Alzheimer's disease and identification of a novel oleamide with enhanced microglial ****ocytosis and anti-inflammatory activity.
Ano Y, Ozawa M, Kutsukake T, Sugiyama S, Uchida K, Yoshida A, Nakayama H.
PLoS One. 2015 Mar 11;10(3):e0118512. doi: 10.1371/journal.pone.0118512. eCollection 2015.
PMID: 25760987 Free PMC article.
6.
Identification of a novel dehydroergosterol enhancing microglial anti-inflammatory activity in a dairy product fermented with Penicillium candidum.
Ano Y, Kutsukake T, Hoshi A, Yoshida A, Nakayama H.
PLoS One. 2015 Mar 11;10(3):e0116598. doi: 10.1371/journal.pone.0116598. eCollection 2015.
PMID: 25760331 Free PMC article.

Interesting, anything that combats Alzheimer's or dementia is a great thing, and more and more progress is being made daily on that front.

Hopefully they can get more research on this and find ways to expand the use of it in foods and recipes, assuming that it actually proves to work like they hope it does.

Eat camembert cheese and have a glass of wine and be merry.

Makes me wonder what thr prevalence of alzheimers is amongst the French vs non cheese eating populations .

Stupid@17 said:

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Eat camembert cheese and have a glass of wine and be merry.

Makes me wonder what thr prevalence of alzheimers is amongst the French vs non cheese eating populations .

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19.29/100,000 compared to 32.44/100,000 in the US

Mexico is one of the lowest at 3.36/100,000, which surprised me.

Link