The new South Park special "The End of Obesity" has the kids navigating the American health care system to get Cartman semaglutide meds. Spot on.

Just reiterating. Please make sure you are maintaining a consistent workout program while taking these meds. These things take a decent chunk of lean body mass for the weight loss as well so you want to be training to help maintain your strength.

wangus12 said:

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Just reiterating. Please make sure you are maintaining a consistent workout program while taking these meds. These things take a decent chunk of lean body mass for the weight loss as well so you want to be training to help maintain your strength.

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100%

You should also do consistent resistance training when dieting even if you're not using a GLP1.

Preferably, your resistance training should have more of a hypertrophy focus in order to preserve muscle

True Anomaly said:

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wangus12 said:

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Just reiterating. Please make sure you are maintaining a consistent workout program while taking these meds. These things take a decent chunk of lean body mass for the weight loss as well so you want to be training to help maintain your strength.

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100%

You should also do consistent resistance training when dieting even if you're not using a GLP1.

Preferably, your resistance training should have more of a hypertrophy focus in order to preserve muscle

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How much daily protein should we target? 1g per lb is what I've seen but there's no way I'm hitting that target. I assume it's lower if you have a BMI over 30. More of 1g per lb lean body mass might make more sense?

Went to the doc today. A1C is down 2 points and I've lost about 12 pounds.

Starting Zepbound next week. Interested to see how it goes.

AggieMainland said:

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Starting Zepbound next week. Interested to see how it goes.

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Eat 1/2 portions, high protein, high fiber, take a multivitamin. Slow down your eating pace significantly or you will overeat and feel horribly bloated.

I started a thread for this video but thought this part would be relevant to this thread. Video is queued up at the part discussing Ozempic. Fair warning they are not fans.

Any recs on where to get a semiglutide? One doctor gave a crazy high quote. Any luck with online places like Hims or Henrys?

Eli Lilly Issues Cease-And-Desist Letters to Compounders Over Weight-Loss Drug Copies As Shortage Resolves (yahoo.com)

Finding cheap tirzepatide GLP-1 from online compounding pharmacies may get more difficult with this action by Lilly.

I recommend Mochi. (referral code 4RBO4O for $40 off first virtual visit with doctor). Easy scheduling. Never had an issue with delivery. I picked them because they partner with the most well-known compounding pharmacies. Not the smaller ones no one has heard of).

$79/month for subscription + $99 for the semaglutide. So $178 per month total.

Required to meet with doctor every 3 months. They also have dietitians available. That is optional but included in the subscription. The doctor i work with on there lost a ton of weight on glp-1s so there is value there.

edit: the doctors name is Jeffrey Hackworth. Recommend if you go with Mochi.

VP at Pierce and Pierce said:

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Any recs on where to get a semiglutide? One doctor gave a crazy high quote. Any luck with online places like Hims or Henrys?

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My GP referred me to a local compounding pharmacy. I pay $148, delivered, for a 6 week supply of generic GLP-1 Semaglutide.

I've been on it for about 4 months and have been on the 50 unit dosage for the about 3 months of that.

As of Friday I was down around 35 lbs. I can wear clothes I haven't been able to in years and am at a lower weight than when I got married 7.5 years ago.

It took awhile to get used to but now I just know that I can't eat as much. Plenty of leftovers.

Looking forward to losing another 20-30 lbs.

AggieRuss said:

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I have crossfit trained for 1 year and have eaten healthy prepped meals consistently for the last year. I'm 5'10", 47 years old and started at 215 pounds. I was definitely stronger from working out but could only lose about 7 pounds, had flab everywhere, had crazy sugar urges and always thought about food. I had a BMI of 33%. I have been on a compounded semaglutide for about 4 months. I still workout 4-5 days/week. I still eat prepped meals but I now weigh 179 pounds. My BMI is about 23%. The semaglutide is the only thing I have changed. I went to my yearly checkup 2 weeks and all of my blood tests came back perfect! No pre-diabetes or anything even close to address. My doc emailed me to say that I was in exceptional shape and to keep up the semaglutide, eating properly and working out. My goal is 170-175. Eat properly, take fiber and drink a ton of water.

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Same situation here. My idea is that I eat healthy and workout but couldn't lose weight. Just turned 50. started Tirzeptide 6 weeks ago and down about 16 pounds. Avg of 2-2.5 lbs per week. I took one week off just to see the difference and it wasn't super noticeable.

I decided to try it after my wife lost ~40 pounds on Ozempic. I just wanted a kick start to losing weight and it definitely works.

but some people think and probably do take semiglutides and still eat pizza and crap, and probably still works but once you get off, those people are most likely to gain it back.

I don't think I will have any trouble maintaining once I get to my goal weight. But will take ~ 5-6 months so going slow and happy with 2 lbs per week.

It really reduces cravings and over eating. Also becoming very popular in addiction circles like AA because it does reduce cravings. Hate to say it, and my wife probably is happy with it, but does reduce seggs cravings too.

does anyone have any skepticism or concern this becomes the next "opiod" type thing? it just seems too good to be true - which often times means there's something lurking we havent thought about yet...

Many people feel this way. Many insurance companies that write pharmacist e&o or professional liability for compound pharmacies are starting to exclude semaglutide claims too.

Diabetics have been prescribed glp1 antagonists going back 20 years now. It just took some Hollywood folks to do it and for companies to make it not a needle stabbing yourself process and boom. Wildfire.

Honestly, this should lower our overall healthcare costs if it prevents CV disease. Diabetes. And other weight related ailments.

Ya'll do what you want but at least for me I wouldn't take these. There are two guys in my office that are ~60 and are taking one of these. They have both lost a bunch of weight but haven't changed any other behaviors. They both look like they lost all their muscle and while thinner look all hunched forward and terrible. Zero chest anymore.

Someone above said they couldn't lose weight. Well I said the same thing. I felt I was eating healthy and good portions. My Dr even asked me if I wanted the weight loss drug. Turns out I was just eating too much!!! I quit eating breakfast and fast till ~11-12. I eat far smaller portions and do my best not to eat any bread type carbs and zero sugar/sweets. I also exercise cardio 5-6X a week (bike, walk, run) and strength train 3-4 times a week. I'm down 20 lbs and have much more muscle/tone. I'm pretty happy with this and plan on keeping it up indefinitely.

If you are using the drugs as a tool for short term, along with diet and exercise, then I would agree with it. Otherwise you are just going to blow up again once you are off it. Long term use....Count me the hell out. I'm trying my best to get off my blood pressure and statin and reduce the amount of drugs I'm taking.

Agree BCOBQ98. I plan only to take a few months and exercise and eat very well daily.

But I do see the people that don't change habits and they do lose a lot of muscle and look older. I know muscle loss is a big concern in women taking it. I don't mind losing some muscle if I can lose the 40 lbs. of fat i have in my belly.

And you have to maintain at least 150 grams of protein a day if not more. 100 minimum for women.