I knew a cop who investigated a scene where there was a fight in a pool hall. One guy pulled a .25 auto, and emptied it into his adversary. Said adversary then picked up the shooter and threw him down on a pool table, breaking his back.
In another case, I once found the lock shot off my farm gate, and ruts through an irrigated wheat field, where county deputies were chasing a piece of trash after he had spent a night raping and abusing his ex-wife. He ended the chase by pulling into another farmstead, and shooting himself in the forehead with his .22. Bullet failed to penetrate, and he got taken to jail with a bandaid and a bad headache.
So while a .22 magnum is better than nothing, I wouldn't bet my life on it.