I am a die hard 49ers fan, and the Seahawks' trade of Russell Wilson to Denver Broncos will shake the NFC West and AFC West. When Russell Wilson started 9 straight full seasons from 2012 to 2020, the Seahawks never finished worse than 9-7. But without Russell Wilson, the Seahawks will probably finish last in the NFC West for the 2nd year in a row. The defending Super Bowl champion Rams will be favored to win the NFC West again. The 49ers and Cardinals will probably be competing for 2 of the 3 NFC Wildcard playoff spots, but I won't be surprised if either the 49ers or Cardinals wins the NFC West in 2022.
The AFC West will become more competitive with quarterbacks Patrick Mahomes, Justin Herbert, Russell Wilson, and Derek Carr playing in the same division. The Kansas City Chiefs have won 6 straight AFC West division titles from 2016 to 2021, but that streak might end in 2022.