Looking for R&P perspective re: origins of CV vaccines

2,286 Views | 40 Replies | Last: 3 yr ago by PabloSerna
amercer
How long do you want to ignore this user?
AG
I've used 293 cells my whole career, and my lab continues to use them on a daily basis. They are the workhorse of research biomedical tissue culture. When it comes to manufacturing, most antibodies are made in immortalized hamster cells, and viruses and vaccines are made in many systems from cancer cell lines to insect cell lines.

I can tell you that the 293s in my lab probably bear little resemblance to the cells originally harvested from that fetus 50 years ago. I'm sure that the differences (and all the good that's come from the cells) don't resolve the original sin of collecting them in some people's opinions, but it's an interesting mirror to the ongoing debate about statues and institutions in this country.

My company manufactures our gene therapy products in a 293 line. Our most advanced clinical programs are for fatal rare genetic childhood diseases. The kind of diseases that if they come up on a prenatal screen, some parents might choose to just abort. So there is an ethical brain teaser for you.
amercer
How long do you want to ignore this user?
AG
If you want a coronavirus vaccine clear of this issue the one from Novavax will be made in insect cells. They've never actually brought a product to market, but they look ok here. I can't tell you 100% that none of there QC or other assays don't use 293 cells. They are kind of ubiquitous in biopharma
erudite
How long do you want to ignore this user?
https://www.vatican.va/roman_curia/congregations/cfaith/documents/rc_con_cfaith_doc_20201221_nota-vaccini-anticovid_en.html
Quote:

Since the first vaccines against Covid-19 are already available for distribution and administration in various countries, this Congregation desires to offer some indications for clarification of this matter. We do not intend to judge the safety and efficacy of these vaccines, although ethically relevant and necessary, as this evaluation is the responsibility of biomedical researchers and drug agencies. Here, our objective is only to consider the moral aspects of the use of the vaccines against Covid-19 that have been developed from cell lines derived from tissues obtained from two fetuses that were not spontaneously aborted.

1. As the Instruction Dignitas Personae states, in cases where cells from aborted fetuses are employed to create cell lines for use in scientific research, "there exist differing degrees of responsibility"of cooperation in evil. For example,"in organizations where cell lines of illicit origin are being utilized, the responsibility of those who make the decision to use them is not the same as that of those who have no voice in such a decision".

2. In this sense, when ethically irreproachable Covid-19 vaccines are not available (e.g. in countries where vaccines without ethical problems are not made available to physicians and patients, or where their distribution is more difficult due to special storage and transport conditions, or when various types of vaccines are distributed in the same country but health authorities do not allow citizens to choose the vaccine with which to be inoculated) it is morally acceptable to receive Covid-19 vaccines that have used cell lines from aborted fetuses in their research and production process.

3. The fundamental reason for considering the use of these vaccines morally licit is that the kind of cooperation in evil (passive material cooperation) in the procured abortion from which these cell lines originate is, on the part of those making use of the resulting vaccines, remote. The moral duty to avoid such passive material cooperation is not obligatory if there is a grave danger, such as the otherwise uncontainable spread of a serious pathological agent--in this case, the pandemic spread of the SARS-CoV-2 virus that causes Covid-19. It must therefore be considered that, in such a case, all vaccinations recognized as clinically safe and effective can be used in good conscience with the certain knowledge that the use of such vaccines does not constitute formal cooperation with the abortion from which the cells used in production of the vaccines derive. It should be emphasized, however, that the morally licit use of these types of vaccines, in the particular conditions that make it so, does not in itself constitute a legitimation, even indirect, of the practice of abortion, and necessarily assumes the opposition to this practice by those who make use of these vaccines.

4. In fact, the licit use of such vaccines does not and should not in any way imply that there is a moral endorsement of the use of cell lines proceeding from aborted fetuses. Both pharmaceutical companies and governmental health agencies are therefore encouraged to produce, approve, distribute and offer ethically acceptable vaccines that do not create problems of conscience for either health care providers or the people to be vaccinated.
5. At the same time, practical reason makes evident that vaccination is not, as a rule, a moral obligation and that, therefore, it must be voluntary. In any case, from the ethical point of view, the morality of vaccination depends not only on the duty to protect one's own health, but also on the duty to pursue the common good. In the absence of other means to stop or even prevent the epidemic, the common good may recommend vaccination, especially to protect the weakest and most exposed. Those who, however, for reasons of conscience, refuse vaccines produced with cell lines from aborted fetuses, must do their utmost to avoid, by other prophylactic means and appropriate behavior, becoming vehicles for the transmission of the infectious agent. In particular, they must avoid any risk to the health of those who cannot be vaccinated for medical or other reasons, and who are the most vulnerable.

6. Finally, there is also a moral imperative for the pharmaceutical industry, governments and international organizations to ensure that vaccines, which are effective and safe from a medical point of view, as well as ethically acceptable, are also accessible to the poorest countries in a manner that is not costly for them. The lack of access to vaccines, otherwise, would become another sign of discrimination and injustice that condemns poor countries to continue living in health, economic and social poverty.
The Sovereign Pontiff Francis, at the Audience granted to the undersigned Prefect of the Congregation for the Doctrine of the Faith, on 17 December 2020, examined the present Note and ordered its publication.
Rome, from the Offices of the Congregation for the Doctrine of the Faith, on 21 December 2020, Liturgical Memorial of Saint Peter Canisius.

Seems like the pope just approved the vaccine for use.
PabloSerna
How long do you want to ignore this user?
AG
I had a Priest friend tell me one time... "The Holy Water in Rome isn't any holier than the Holy Water in your local Church."

In this case, I am grateful for Mother Church on putting this out. It clears things up. My wife works in a Catholic hospital and they were among the first people in Austin to be vaccinated. HTH



PabloSerna
How long do you want to ignore this user?
AG
Using this logic, one would refuse to own land since it was taken (some might say stolen) from Native Americans.
Refresh
Page 2 of 2
 
×
subscribe Verify your student status
See Subscription Benefits
Trial only available to users who have never subscribed or participated in a previous trial.