A few things I'm trying to foresee and reconcile with the story given what we now know.
A - Claims to the Kingdoms
1) Dany wants all 7 kingdoms
2) Jon has been declared King of the North. There seems to be a strong desire for the North to retain independence (Nexit?)
Do Dany and Jon come to war due to ideological differences? Add to it that LF would be against Dany's rein - wanting the throne for himself - I could see him backing the North's claim to independence with the Vale's own until he can, in his own mind at least, unite the 7 kingdoms.
Or, does Jon rally behind Targaryen? If he knew of his birth he might, but with that knowledge, he'd again be at odds to Dany's claim to Westros.
B - Dany's Fight for Freedom at Odds with Her Desire for Rule Over Westros
I'm definitely overthinking this, but given Dany's fighting for slave's freedom and liberty, her view of men and women on equal footing, and her generally progressive viewpoints compared to the norms of that world, for some reason I see that maturing into an introduction of democracy/republic. This contradicts my Point A above, I know, but her motives and actions in Essos seem to ideologically collide with her drive for absolute rule in Westros. I'm fine with that being her character (in fact, probably my favorite part of her character and story), but am curious to see how that plays out: does her belief that she will be a just Queen become corrupted with power, or does her power become compromised by her empathy for her people? Or, is there some other path (like introducing a constitution/senate)?
C - What's Up with Greyscale?
There's gotta be a tie with the White Walker Disease right? Are they related in anyway? Others have thought that perhaps Greyscale will be introduced to the WW as a pox, but what if it's the opposite and they are more in concert with each other? Stone men and wights seem to have similarities, and mysterious leaders. Perhaps Euron has Greyscale - he has traveled pretty much everywhere. I see this as Connington/Jorah's path.