This is big news, no? I'm surprised no one is discussing this.

cisgenderedAggie said:

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Pretty sure there was evidence of this real early in the pandemic. Not many wanted to talk about it then either.

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Plenty of people talked about it. This information in and of itself isn't particularly helpful because obviously a large portion of the population doesn't have this immunity for whatever reason.

Gordo14 said:

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cisgenderedAggie said:

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Pretty sure there was evidence of this real early in the pandemic. Not many wanted to talk about it then either.

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Plenty of people talked about it. This information in and of itself isn't particularly helpful because obviously a large portion of the population doesn't have this immunity for whatever reason.

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Yeah, they published it too.

https://www.cell.com/cell/fulltext/S0092-8674(20)30610-3

Quote:

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Understanding adaptive immunity to SARS-CoV-2 is important for vaccine development, interpreting coronavirus disease 2019 (COVID-19) pathogenesis, and calibration of pandemic control measures. Using HLA class I and II predicted peptide "megapools," circulating SARS-CoV-2-specific CD8+ and CD4+ T cells were identified in 70% and 100% of COVID-19 convalescent patients, respectively. CD4+ T cell responses to spike, the main target of most vaccine efforts, were robust and correlated with the magnitude of the anti-SARS-CoV-2 IgG and IgA titers. The M, spike, and N proteins each accounted for 11%27% of the total CD4+ response, with additional responses commonly targeting nsp3, nsp4, ORF3a, and ORF8, among others. For CD8+ T cells, spike and M were recognized, with at least eight SARS-CoV-2 ORFs targeted. Importantly, we detected SARS-CoV-2-reactive CD4+ T cells in 40%60% of unexposed individuals, suggesting cross-reactive T cell recognition between circulating "common cold" coronaviruses and SARS-CoV-2.

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That's a Cell publication published in May 2020.

NewOldAg said:

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This is big news, no? I'm surprised no one is discussing this.

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I'm not.

I've always wondered if common cold T-cells had anything to do with some people that experience lighter symptoms from covid variants, particularly delta. Obviously not the only thing contributing to milder infection, but one of multiple variables.

Considering this information, I would love to see a study of outcomes from people who continued on with normal life vs those who isolated themselves heavily (does anything like that exist?)

Those who went out more should have had more contact that could provide T-cell protection than those that isolated to the extreme.