KidDoc said:
I agree with Cis and Hill. Fluovoxamine data is really exciting.
The fluvoxamine data is not really convincing. The TOGETHER trial for some reason used a composite outcome of >6hr time in ER or hospitalization as their primary outcome, with the time spent in the ER being the only statistically significant portion of the composite, as it had no effect on hospitalization. Time spent in the ER is a worthless outcome measure as time spent in the ER frequently has nothing to do with disease severity.
The pre-test probability of efficacy is so low that SSRIs would have any benefit in COVID that it would take indisputable data with patient centered outcome measures if looking at this from a Bayesian perspective. From a non-Bayesian perspective, the fluvoxamine arm of the TOGETHER trial is extremely weak data, with everything outside of time spent in an ER being negative on secondary outcomes (Death, Mechanical ventilation, Need for oxygen supplementation, hospitalization, days spent in hospital).
OP should talk with his doctor ASAP, and stay on top of his O2 sats. If it drops below 90%, please go to an ER immediately. Right now, the best evidence we have for early disease is monoclonal antibody infusion, preferably sotrovimab for Omicron, although Texas has just run out of supply and at least my hospital no longer has any available supply.
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