Is One Shot Enough?

2,664 Views | 28 Replies | Last: 3 yr ago by ToddyHill
nattychamps22
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Will pass on. Thanks!
terradactylexpress
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No
Aggie95
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AG
she took the risk of myocarditis with one shot
aggierogue
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It's a legitimate question. Since the vaccine is not giving anywhere near full immunity and we're seeing so many breakthrough cases, would one shot provide the goal of keeping you out of the hospital when you contract Covid?

At this point I'm not expecting a vaccine to prevent me from getting Covid. I'm hoping that it prevents me from getting really sick. So would one shot provide that protection?

And yes getting a second shot would seem to have some risk of side effects the OP's friend is concerned about. Not to mention I've seen many on this board say that the second dose made them feel pretty bad.
bay fan
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S
I am not at all sure why she bothered. She took "risk" with the shot she had, seems to me it's for nothing in light of what we do actually know about what it takes to be effective. Hope she reconsiders and finishes.
aggierogue
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bay fan said:

I am not at all sure why she bothered. She took "risk" with the shot she had, seems to me it's for nothing in light of what we do actually know about what it takes to be effective. Hope she reconsiders and finishes.
My neighbor did the same. He only took one shot back around March or April. He said he immediately regretted getting it and he just did it in in a moment at his work where they were offering the vaccine. His wife and 3 children aren't vaccinated (all over 12). I know that really doesn't address your post, but I would imagine there are many people like that.

But you really didn't address the OP's question. I guess I wouldn't expect much data out there to address this specific question especially since there seems to be mostly an all-out effort to push for vaccinations.

Hypothetically speaking though, what if full 2-dose vaccination has fallen to 50 percent protection against contracting the virus. For someone like me, I'm not expecting it to keep me from getting Covid. My ultimate concern is not ending up in emergency room if/when I catch it.

So it would be interesting to know how much one dose would help one's immune system to the point of not ending up getting really sick.
bay fan
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I think it falls to reason that if initially when the vaccine first came out one shot would have provided lasting benefits they would have called for a single dose so more people had access and more quickly slow the spread. They didn't because it wasn't effective.
Not a Bot
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There are not enough circulating antibodies after one dose. Confirmed by multiple studies that one dose is not enough. Someone can find the link, but it's something like 20% or less protection.

Two doses does provide fairly significant protection against both contraction and prevention of severe disease. Study released the other day out of the UK showed breakthrough cases are typically less symptomatic.

And Moderna has been shown to be more effective against the Delta than the others.
cisgenderedAggie
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bay fan said:

I think it falls to reason that if initially when the vaccine first came out one shot would have provided lasting benefits they would have called for a single dose so more people had access and more quickly slow the spread. They didn't because it wasn't effective.


That's not reason, it's revisionist history. No one ever tested only one shot. It was discussed, but 2 shots were chosen because it would assume a booster would lead to stronger protection than a single shot. Not because a single shot was insufficient. No one knows that because no one tested it.

A booster is probably better than a single shot. A single shot is almost certainly better than no vaccine at all. Either way, you are going to be infected at some point, which will most likely make any subsequent immunity improved.
aggierogue
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bay fan said:

I think it falls to reason that if initially when the vaccine first came out one shot would have provided lasting benefits they would have called for a single dose so more people had access and more quickly slow the spread. They didn't because it wasn't effective.
Perhaps. But all the data I see is how your protection from contracting the virus goes up from the 50s to the 80/90s after second dose.
This question is more about protection from severe illness rather than protection from contraction.

For someone in my situation, this is a pretty big distinction.

B/c if the first dose won't keep me out of the hospital, I'm not sure I am willing to risk going the vaccine route if I'm not going to have decent immunity for more than 6 weeks (28 days between first and second dose; full immunity two weeks after second dose).

Not trying to be argumentative. I'm just gathering information.
aggierogue
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Captain Positivity said:

There are not enough circulating antibodies after one dose. Confirmed by multiple studies that one dose is not enough. Someone can find the link, but it's something like 20% or less protection.

Two doses does provide fairly significant protection against both contraction and prevention of severe disease. Study released the other day out of the UK showed breakthrough cases are typically less symptomatic.

And Moderna has been shown to be more effective against the Delta than the others.
Good to know if this is accurate.

And my doctor last week told me he would do Pfizer over Moderna based strictly on the ingredients in the vaccines. He said he recognized the ingredients (from med school studies) where Moderna had some stuff he didn't recognize. Just repeating what he told me. His advice didn't seem to be based on effectiveness of the two, which I thought was odd.
Teslag
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Let's be honest here, the chances of someone 23 years old and healthy going to the hospital are statistically low it's not worth even being concerned about.
Stringfellow Hawke
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Just be safe. Wear a mask at all times as well as get all vaccines at once.
bigtruckguy3500
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Salute The Marines said:

Let's be honest here, the chances of someone 23 years old and healthy going to the hospital are statistically low it's not worth even being concerned about.
Admitted to the hospital, very unlikely. However plenty go to the hospital due to how miserable they are, wanting something to be done. Also, having medium to long term side effects from infection is decently high.
Teslag
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bigtruckguy3500 said:

Salute The Marines said:

Let's be honest here, the chances of someone 23 years old and healthy going to the hospital are statistically low it's not worth even being concerned about.
Admitted to the hospital, very unlikely. However plenty go to the hospital due to how miserable they are, wanting something to be done. Also, having medium to long term side effects from infection is decently high.


How high? Give me concrete verifiable numbers for medium to long term effects for people in their early 20's.
KidDoc
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Stringfellow Hawke said:

Just be safe. Wear a mask at all times as well as get all vaccines at once.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
Teslag
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Many years ago in basic training I literally got "all the vaccines at once".


Ouch.
St Hedwig Aggie
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On the TV channel on the plane ride I took today, the news channel kept talking about the "MU" variant. Is that the new Greek letter to be used after "delta" abates some?!!
Make Mental Asylums Great Again!
KidDoc
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West Point Aggie said:

On the TV channel on the plane ride I took today, the news channel kept talking about the "MU" variant. Is that the new Greek letter to be used after "delta" abates some?!!
Mu is actually several steps after Delta-- but many variants are not significant so you don't hear about them. Kinda like a hurricane that just fizzles out in the ocean.

Greek alphabet - Wikipedia
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St Hedwig Aggie
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KidDoc said:

West Point Aggie said:

On the TV channel on the plane ride I took today, the news channel kept talking about the "MU" variant. Is that the new Greek letter to be used after "delta" abates some?!!
Mu is actually several steps after Delta-- but many variants are not significant so you don't hear about them. Kinda like a hurricane that just fizzles out in the ocean.

Greek alphabet - Wikipedia

I'm quite familiar with the Greek alphabet after many many math courses, but this one in particular (at least per the news segment I saw) was about the MU variant in CA. Is there something in writing that says they have to follow the alphabet or can they just call it Omega or Lambda if they feel like it?

I'm partial to Tau. Used in meteorology and climate as the residence time of a gas in the atmosphere! Way cooler than some nasty virus!
Make Mental Asylums Great Again!
bigtruckguy3500
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Salute The Marines said:

bigtruckguy3500 said:

Salute The Marines said:

Let's be honest here, the chances of someone 23 years old and healthy going to the hospital are statistically low it's not worth even being concerned about.
Admitted to the hospital, very unlikely. However plenty go to the hospital due to how miserable they are, wanting something to be done. Also, having medium to long term side effects from infection is decently high.


How high? Give me concrete verifiable numbers for medium to long term effects for people in their early 20's.
Good question. I haven't actually seen the data broken down by type of side effect and by age group. Actually the Navy is doing the CHARM 2.0 study that should answer this question quite well. I've seen some of the data, but not everything tabulated. One of the peculiar cases I saw was a Marine that had post covid changes on his EKG. Last I heard he was getting evaluated be cardiology, I'll have to see if I can follow up with that. Could be a clinically silent conductive change in his heart, or could manifest into something later in life. Data is still being gathered.

I don't otherwise have a breakdown by age, specific to the 20 year age group. I think I might have seen myocarditis as high as 4-5 out of 10,000. Do you have data to suggest that his age group doesn't have medium to long term effects? All anecdotes here, but the local children's hospital has a 17 year old on ECMO right now. They're getting several teenagers a day with low blood oxygen. Most are in the low 90's, but they're getting some in the 80's here and there. Decent number of those are due to secondary pneumonias. Unclear how those affected in this way will fare long term. Will they be at higher lifetime risk for COPD/emphysema? Kinda early to tell as they still have a lot of functional lung reserve.

We know older adults, are getting kidney injuries after COVID. Often these are found incidentally after they present to the hospital for other issues. Younger folks might not present to the hospital, so they may have a clinically silent kidney injury, or compensate from it well. We know in adults that kidney injuries put them at risk for dialysis later in life. No evidence yet if kids get COVID nephropathy, and if they do, at what point in life will it affect them, if ever.

I guess the question is, do we know enough about it to dismiss the effects on older adults as something younger folks can't have? A year and a half ago people were desperately trying to dismiss this as just a flu. Then it became only deadly to the elderly. Then only to the elderly + middle aged people with comorbidities. Then the only thing that mattered was the death rate, hospitalizations or long term effects shouldn't be a consideration. So on and so forth. Now we're seeing younger and younger folks affected.

Not sure what the solution is, but I don't think it should be to dismiss potential risk simply because we haven't collected the data yet.
Teslag
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That's an awful lot of words to say "I don't have verifiable concrete numbers for those in their early 20's suffering long term damage".

What we do know is that a healthy 23 year old dying of covid is statistical noise at this point. And it probably stands to reason that long covid issues with this age group follows that trend.

I am a huge proponent of the vaccines because their effectiveness cannot be denied by the data. And that's what we need to go on. For some reason, people on all sides of this pandemic have simply refused to go on data and numbers alone and toss emotion and anecdotes aside when determining a personal or community risk analysis.
TheMasterplan
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Just got my first shot today.

I'm ready to **** **** up.
TheMasterplan
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Salute The Marines said:

Many years ago in basic training I literally got "all the vaccines at once".


Ouch.
Ha - same.
traxter
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True, but a year ago only old people were even ending up in the hospital and everyone said we were approaching herd immunity, half of los angeles already had antibodies, etc. Almost all the assumptions we made a year+ ago have been wrong. I'm not saying your assumption that long covid issues are less likely in the 20's is wrong, but I don't understand why you'd be so quick to make such an assumption.

As he said before, just because the data isn't there doesn't mean it's not happening. I just heard on the radio that 9/11 first responders are dropping like flies because of cancer and health issues. I'd be willing to bet in the first year or two after 9/11 there wasn't any data to suggest they'd have the health issues they have now. At one point in time there wasn't any data to suggest that vaping was bad for you, only warnings from doctors that the ingredients are concerning.

Certainly gives me pause when someone says "there's no evidence that ___ is harmful." Does that mean there's data that suggests there's no harm, or there's a lack of data?
Teslag
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But at this point we have 18 months and millions of data points to show us 23 year olds have very little to fear from covid. The trends just aren't there.
BCG Disciple
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One shot is enough for:

1. The previously infected/recovered. Early results indicate it may provide the best protection of all alternatives.

2. Any of the youth. I'd say under 25 would work great with one shot. Several countries only allow one shot from 12-15 year olds, including France and Israel. UK does not recommend anything for kids under 16. One shot has a significantly lower risk of myocarditis in kids than the second shot and still provides some protection.
KidDoc
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BCG Disciple said:

One shot is enough for:

1. The previously infected/recovered. Early results indicate it may provide the best protection of all alternatives.

2. Any of the youth. I'd say under 25 would work great with one shot. Several countries only allow one shot from 12-15 year olds, including France and Israel. UK does not recommend anything for kids under 16. One shot has a significantly lower risk of myocarditis in kids than the second shot and still provides some protection.
I agree with #2 but the data is still pending. I do think a single dose of Moderna will be adequate for children and not have the significant risk of myocarditis.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
BCG Disciple
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Agreed. None of what I said is settled, and I appreciate you calling attention to it.
ToddyHill
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Quote:

One shot is enough for:

The previously infected/recovered. Early results indicate it may provide the best protection of all alternatives.
I believe this is what the protocol is in Israel.

Candidly, I got the Phizer shots and I had a severe reaction to both (wished I had stopped after the first shot). My doctor believes it's due to the fact I had a very symptomatic case of Covid back in May 2020.
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