Do we know yet who has better immunity?

2,867 Views | 22 Replies | Last: 3 yr ago by redcrayon
aggierogue
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AG
Vaccinated who have never had Covid or recovered unvaccinated?

Any real evidence yet?
harge57
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I think its pretty obvious.

The CDC quit reporting breakthrough cases for a reason.
texan12
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Who knows. Caught a snipped of the ever depressing news this morning where vaccinated Johnny Bench cant make the hall of fame induction sept 9th after testing positive this past Friday; and the vaccine may not protect against the new variant.
chjoak
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My wife teaches at a small preschool. One of the teachers there is vaxed + booster, wears a mask all the time and generally stays away from people except at work. Last week she came down with what appeared to be a sinus infection and tested positive when she went to the doc to get antibiotics. Noone else at the preschool (kids included) have shown any signs yet.

One of the mom's of a kid on my son's soccer team is vaxed and tested positive a little over a week ago. Her husband says she has 12 of the listed symptoms and feels kind of like she has the flu. Noone else in the house has gotten it.
Harry Stone
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https://www.sciencedaily.com/releases/2021/08/210816143933.htm
KidDoc
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Vaccine then infection appears to be the best.

The problem with natural immunity is that it seems to be highly variable from person to person both in duration and efficacy.

Just get titers done if you want to know your status, free in Texas with the Texas Cares project. As the article linked states though titers are not the whole story and even with low titers you are likely safe if vaccinated or recovered.
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texan12
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chjoak said:

My wife teaches at a small preschool. One of the teachers there is vaxed + booster, wears a mask all the time and generally stays away from people except at work. Last week she came down with what appeared to be a sinus infection and tested positive when she went to the doc to get antibiotics. Noone else at the preschool (kids included) have shown any signs yet.

One of the mom's of a kid on my son's soccer team is vaxed and tested positive a little over a week ago. Her husband says she has 12 of the listed symptoms and feels kind of like she has the flu. Noone else in the house has gotten it.


Transmission can occur through the eyes. Don't think it's as probable as mouth or nose though.
redcrayon
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Comparing SARS-CoV-2 natural immunity to vaccine-induced immunity: reinfections versus breakthrough infections | medRxiv
Port of Hepatis
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There is a study out there that found vaccinated are 2.34 times more protected than those who just had infection . Published in medical literature. Legit study. Don't recall the journal.
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bay fan
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S
Two different doctors stating Vaccine first are the only voices worth listening to.
aggierogue
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Port of Hepatis said:

There is a study out there that found vaccinated are 2.34 times more protected than those who just had infection . Published in medical literature. Legit study. Don't recall the journal.
What are your thoughts on redcrayon's link?


Quote:

Conclusions This study demonstrated that natural immunity confers longer lasting and stronger protection against infection, symptomatic disease and hospitalization caused by the Delta variant of SARS-CoV-2, compared to the BNT162b2 two-dose vaccine-induced immunity. Individuals who were both previously infected with SARS-CoV-2 and given a single dose of the vaccine gained additional protection against the Delta variant.
aggierogue
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bay fan said:

Two different doctors stating Vaccine first are the only voices worth listening to.
I'm actually coming around to considering the vaccine, but I'm in the middle of a storm at my school of Covid cases. I've been in and around students/teachers and classrooms who have tested positive over the last two weeks.

One of my reservations is that I could already have Covid due to the numbers growing in my school or if I were to get the vaccine this weekend, I could catch it from the elevated exposure along with vaccine-induced lowering of my immune system.
bay fan
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S
It's a dilemma I would solve with a discussion with my doctor. My daughter got sick from the vaccine for 24 hours and sick from Covid for 4 days about 6 days post vaccine. That said, she glad to be vaccinated with the best immunity.
What made you reconsider?
Stringfellow Hawke
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texan12 said:

chjoak said:

My wife teaches at a small preschool. One of the teachers there is vaxed + booster, wears a mask all the time and generally stays away from people except at work. Last week she came down with what appeared to be a sinus infection and tested positive when she went to the doc to get antibiotics. Noone else at the preschool (kids included) have shown any signs yet.

One of the mom's of a kid on my son's soccer team is vaxed and tested positive a little over a week ago. Her husband says she has 12 of the listed symptoms and feels kind of like she has the flu. Noone else in the house has gotten it.


Transmission can occur through the eyes. Don't think it's as probable as mouth or nose though.


Through the eyes? Not as probable through nose or mouth?

What do you mean?
aggierogue
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bay fan said:

It's a dilemma I would solve with a discussion with my doctor. My daughter got sick from the vaccine for 24 hours and sick from Covid for 4 days about 6 days post vaccine. That said, she glad to be vaccinated with the best immunity.
What made you reconsider?


Just the fact that it is spreading so much at my work and continuing to read about it. I'm still on the fence, but I'd probably get it if I had a couple of weeks off.

Spoke to my doctor Wednesday and he was not super helpful on whether I should get it in my current situation. He basically said you don't want to contract it while gettin vaccinated or in that early period afterward. But he also said he thought cases were going to continue to go up. Our visit was by Zoom and felt rushed, and I didn't get off the Zoom feeling good about getting it with so many positive cases around me.
bay fan
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S
I'd take hone test and go get it this afternoon when you have 2 more days off. Stay healthy
bigtruckguy3500
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aggierogue said:

bay fan said:

Two different doctors stating Vaccine first are the only voices worth listening to.
I'm actually coming around to considering the vaccine, but I'm in the middle of a storm at my school of Covid cases. I've been in and around students/teachers and classrooms who have tested positive over the last two weeks.

One of my reservations is that I could already have Covid due to the numbers growing in my school or if I were to get the vaccine this weekend, I could catch it from the elevated exposure along with vaccine-induced lowering of my immune system.
The vaccine won't lower your immune system. If anything it will sensitize it to COVID and give it a head start should you get exposed. I see no draw back to getting the vaccine while in a high risk environment.

Think about it. If you got vaccinated today. Within about 10 days you're going to start producing antibodies, and within about 12 days you're going to have reasonable protection against infection. The average time to develop COVID symptoms from exposure is about 5 days, maybe as much as 7. And you're potentially infectious for 10 days after symptom onset. If you were vaccinated 3 days before exposure, you're giving your immune system a 3 day head start on clearing the virus from your system. It's not an exact science, but it should result in shorter illness duration and fewer symptoms.

Most health care workers were very high risk for exposure when the vaccine came out, and most chose to get it. Some got COVID within a few days of vaccination, and they had no issues.

Port of Hepatis
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Interesting study.

US vs Israel populations. Not much else seems terribly different except the Israel study was Pfizer only. Evidence says Moderna elicits more antibodies.

But here's the question: knowing that the vaccine makes the infection lesser compared to vaccine naive, wouldn't you prefer being a vaccine breakthrough rather than a vaccine naive infected?
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
redcrayon
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Port of Hepatis said:

Interesting study.

US vs Israel populations. Not much else seems terribly different except the Israel study was Pfizer only. Evidence says Moderna elicits more antibodies.

But here's the question: knowing that the vaccine makes the infection lesser compared to vaccine naive, wouldn't you prefer being a vaccine breakthrough rather than a vaccine naive infected?
I'd just like for the entities requiring vaccines to treat natural immunity the same as vaccine immunity.
Zobel
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https://www.medrxiv.org/content/10.1101/2021.08.18.21262237v1

I think this is the best evidence I've seen. Active random surveillance vs retrospective / observational studies.
jreg90
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https://covid19criticalcare.com/

Great source of info. Front Line Covid Critial Care Alliance. Came from my daughter who is a Covid nurse (50-60 hours a week). Half of her patients have been vaccinated.
jreg90
(Miss my sweet little Rachel 2002-2017)
ToddyHill
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Thank you for posting that. I think one of the most important quotes from that article....

Quote:

The results also showed that the T-cell response in the weeks after mRNA vaccination includes T-cell types normally elicited by natural infection -- and in general, natural viral infection is known to be capable of inducing T-cell protection that lasts years and even decades.

I wouldn't wish Covid on anyone (my experience, thankfully, did not include any respiratory issues, but frankly, Covid kicked me to the curb).

I donate Platelets about once a month. After I recovered from Covid the Blood Bank tested me three times for Antibodies...and yet I didn't qualify to donate plasma. I wondering/hoping that my T-cells are there and fighting on my behalf.

As an aside, there's a study from Israel that claims those who've been infected only need one shot, for what that's worth.
Harry Stone
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ToddyHill said:

Thank you for posting that. I think one of the most important quotes from that article....

Quote:

The results also showed that the T-cell response in the weeks after mRNA vaccination includes T-cell types normally elicited by natural infection -- and in general, natural viral infection is known to be capable of inducing T-cell protection that lasts years and even decades.

I wouldn't wish Covid on anyone (my experience, thankfully, did not include any respiratory issues, but frankly, Covid kicked me to the curb).

I donate Platelets about once a month. After I recovered from Covid the Blood Bank tested me three times for Antibodies...and yet I didn't qualify to donate plasma. I wondering/hoping that my T-cells are there and fighting on my behalf.

As an aside, there's a study from Israel that claims those who've been infected only need one shot, for what that's worth.



Here's the full publication from Cell.

https://www.cell.com/immunity/fulltext/S1074-7613(21)00308-3
redcrayon
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ToddyHill said:

Thank you for posting that. I think one of the most important quotes from that article....

Quote:

The results also showed that the T-cell response in the weeks after mRNA vaccination includes T-cell types normally elicited by natural infection -- and in general, natural viral infection is known to be capable of inducing T-cell protection that lasts years and even decades.

I wouldn't wish Covid on anyone (my experience, thankfully, did not include any respiratory issues, but frankly, Covid kicked me to the curb).

I donate Platelets about once a month. After I recovered from Covid the Blood Bank tested me three times for Antibodies...and yet I didn't qualify to donate plasma. I wondering/hoping that my T-cells are there and fighting on my behalf.

As an aside, there's a study from Israel that claims those who've been infected only need one shot, for what that's worth.



There is a test called T-detect that you might be interested in.
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