A repurposed drug JAK blocker, used for rheumatoid arthritis, discovered to have potential for severe Covid via #AI, in a randomized trial, has a very significant reduction of mortality (more than dexamethasone or IL-6 blockade) and excellent safetyhttps://t.co/XcW53PtZTr pic.twitter.com/hMNL0ASnrl

— Eric Topol (@EricTopol) September 1, 2021

Jbob04 said:

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I wonder if this is what I've been taking here in the hospital. They told me it was for arthritis but is showing to be a big help with Covid. Been on it since I got here last Friday.

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Kinda how cytotec. It was made to combat heartburn. Then they figured out that if they put it on your cervix, it would help bring on labor.

JAK inhibitors slapped with safety warning today:
https://www.fiercepharma.com/pharma/pfizer-abbvie-lilly-arthritis-drugs-hit-much-dreaded-fda-heart-safety-cancer-warnings?mkt_tok=Mjk0LU1RRi0wNTYAAAF_QXfjac3cEgvqEk0S5xEHrUySYZK6HJbiwJptkvd-KhnsohxFmufTY0x3DV3AKdmbDxlKxU_oYZGJ-Zu-cp1YvbsG843nzjSqGh4a-rn0hArzZlj4OA&mrkid=54486743

Not too surprising, the -tinib class of drugs can produce AEs (ibrutinib, imatinib, etc.)

If you are on oxygen because of having covid, it looks like it might be useful.

Those two lines are pretty close together. What is the actual mortality difference 14% vs 12%? 15% vs 10%?

Looks like better than nothing but not overwhelming, I'm sure it will be researched more.

EDIT: I looked up the Lancet article, it is 15% vs 10% so a 5% reduction. Not bad for a relatively safe last ditch effort on severe cases.

Would that be a number needed to treat of 3? If so, dramatically better than remdesevir and other therapies.

KidDoc said:

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EDIT: I looked up the Lancet article, it is 15% vs 10% so a 5% reduction. Not bad for a relatively safe last ditch effort on severe cases.

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Why wait til it's the point of last ditch?

That's a 33% reduction. That's big.