On another site I'm on, a doctor was talking about that if you get a booster, you should get another "type" of shot as a booster.
His reasoning was the following:
"The viral vectors like JnJ & Astrazenica produce a slightly better T-cell response than Pfizer/Moderna, which produce a slightly better B-cell response. By mixing them you reach an optimal response of both"
He then posted this chart with the following explanation:
"okay so this is a series of comparisons.
Left is Jnj followed by Jnj.
Right is pfizer followed by pfizer.
Middle is Jnj followed by pfizer.
Each square is looking at a different immune response.
Top left is # of antibodies that you make.
Top right is helper T-cell response, very important because they're the field generals who coordinate immunity.
Bottom left is the percentage of antibodies that induce neutralization of the spike protein.
Bottom right is the one to focus on. It's the # of CD8 T-cells, which are the T-cells that you use to fight viruses. Mixing Jnj and Pfizer produce a better CD8 response than any other combination."
His reasoning was the following:
"The viral vectors like JnJ & Astrazenica produce a slightly better T-cell response than Pfizer/Moderna, which produce a slightly better B-cell response. By mixing them you reach an optimal response of both"
He then posted this chart with the following explanation:
"okay so this is a series of comparisons.
Left is Jnj followed by Jnj.
Right is pfizer followed by pfizer.
Middle is Jnj followed by pfizer.
Each square is looking at a different immune response.
Top left is # of antibodies that you make.
Top right is helper T-cell response, very important because they're the field generals who coordinate immunity.
Bottom left is the percentage of antibodies that induce neutralization of the spike protein.
Bottom right is the one to focus on. It's the # of CD8 T-cells, which are the T-cells that you use to fight viruses. Mixing Jnj and Pfizer produce a better CD8 response than any other combination."