mRna as a cancer treatment

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texan12
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10:44a, 7/30/21
https://www.iflscience.com/health-and-medicine/first-cancer-patient-receives-mrna-melanoma-vaccine-in-new-clinical-trial/

Will radiation and chemo be a thing of the past? Prostate, head, and neck cancers also in phase one trials.

" BNT111 is an experimental anti-cancer mRNA treatment as part of BioNTech's FixVac platform. This involves multiple immunotherapy treatments that contain the cellular instructions to create antigens that are shared between cancer types, which are administered to patients in an attempt to induce the immune system into producing antibodies against them. Through doing so, the immune system becomes "trained" into destroying tumors before they become problematic. BNT111 is the most advanced treatment in the FixVac pipeline, and targets four antigens at least one of these antigens are present in over 90 percent of metastatic melanoma cases."
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fightingfarmer09
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10:53a, 7/30/21



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thirdcoast
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11:00a, 7/30/21
AG
Interesting, Ibio is working on cancer therapeutic antibodies treatment too. Wonder if this recent news has to do with increased covid funding.

https://ir.ibioinc.com/news-events/press-releases/detail/162/ibio-establishes-oncology-drug-discovery-pipeline-with
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texan12
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In reply to thirdcoast • 11:12a, 7/30/21
I don't think it's coincidental. The expanded use of mRNA needed to be kicked off with covid for some reason. It is odd that a cancer treatment would not have the green light first.
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Fenrir
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In reply to texan12 • 11:21a, 7/30/21
Free government money vs having to convince investors is a pretty easy choice. I think US government ended up providing $18 billion towards Covid vaccine research. That's a lot of money to get things moving.
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RockOn
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11:53a, 7/30/21
I hope so. I had cancer at 24 and being pumped up with liquid platinum is not fun.
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TommyGun
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1:14p, 7/30/21
AG
My wife's grandfather has been undergoing chemo and radiation treatments periodically over the last few years battling thyroid cancer. He got the Pfizer vaccine in January while he was at MD Anderson getting some images of different cancer areas on his clavicle, throat, and a few other areas. The cancerous spots were small enough that they were going to defer further treatment for at least 6 months. So he goes in last week for his first appointment since then and this time the images showed that the spot on his clavicle had actually shrunk and the other areas were basically unchanged from the last appointment. Keep in mind he had had no other medical treatment other than a covid shot since then. The doctor mentioned that they've been seeing this more and more with those who received one of the mRNA vaccines.
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texan12
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In reply to TommyGun • 1:31p, 7/30/21
How would the covid vaccine help with the cancer? Or was it more so because of the traditional treatments?
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Teslag
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1:40p, 7/30/21
AG
Great. When they come out we will have posters on this board saying they would rather get natural immunity from "weak ass" prostate cancer.
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TommyGun
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In reply to texan12 • 2:31p, 7/30/21
AG
texan12 said:
How would the covid vaccine help with the cancer? Or was it more so because of the traditional treatments?



I have no idea. Just a pure anecdotal story and the doc mentioned they've had some other cases just like his. It might just be pure coincidence. We're just glad he can delay the next round of treatment.
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Gordo14
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3:39p, 7/30/21
I believe the original idea for Moderna was to make a cancer vaccine. The pandemic probably gives mRNA vaccine companies with nearly infinite access to funding which should accelerate this research dramatically compared to 2-3 years ago. The bright side of the pandemic is I think you'll see healthcare advance way faster in the mRNA space than it otherwise would have.
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KidDoc
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3:50p, 7/30/21
AG
The way mRNA vaccines work is you instruct your ribosomes to make a specific protein then spit it out and the immune system attacks that protein structure. For COVID they picked the spike protein from the initial viral strains. The delta variant apparently has a small mutation on this protein which is what is counfounding the vaccines from preventing mild infections.

If you know a protein structure on a cancer cell that is unique and different from other cells you can relatively easily program your myocytes to spit out the protein and get your immune system pissed off at anything showing that protein structure.

This is a technical article from 2016: mRNA Cancer Vaccines - PubMed (nih.gov)
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
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Gunny456
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In reply to texan12 • 9:56a, 8/1/21
AG
My cousin got this vaccine 12 years ago at MD Anderson. He had advanced Melanoma that had reached some lymp glands. He got one shot every thirty days for a year. Then one shot every six months till two years ago. Now he is at one shot annually.
It was not used to treat his cancer but rather as a preventative prophylactic to keep it from returning. He never had any side effects and he is cancer free.
His MD Anderson doc told him that vaccine was the basis and building block for the now Covid vaccines and that is why it was developed so quickly.
Something to think about.

Edit to add. I may be wrong on how many years ago. But at least 8. And he said it was a mRNA based vaccine. He did not say if it was experimental at that time or not.
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Zobel
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10:08a, 8/1/21
AG
Pretty good article here about potential uses for mRNA (and what it might not work for).

https://blogs.sciencemag.org/pipeline/archives/2021/06/29/what-mrna-is-good-for-and-what-it-maybe-isnt
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akaggie05
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11:09a, 8/1/21
AG
The idea of cancer vaccines (training the immune system to attack cancer cells) has been under investigation for a while now. One of the companies I've been watching is Northwest Biotherapeutics. They have a therapy called DCVax where dendritic cells are extracted from a patient's blood, exposed to tumor lysates from samples removed during surgery, and then the "trained" dendritic cells are re-introduced into the blood. It's pretty fascinating stuff.

http://www.nwbio.com
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texan12
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In reply to Zobel • 11:43a, 8/1/21
Zobel said:
Pretty good article here about potential uses for mRNA (and what it might not work for).

https://blogs.sciencemag.org/pipeline/archives/2021/06/29/what-mrna-is-good-for-and-what-it-maybe-isnt


" As has been mentioned in previous posts, the lipid-nanoparticle mRNA vehicles tend to pile up in the liver above all other organs. That's no particular distinction; most things we dose people with in this industry either pile up in the liver or get shredded to some degree each time they pass through it. But we have no good ways to inject someone with mRNA constructs and send them to some particular tissue without dosing every other tissue in the body."

What is wrong with lipids building up in the liver?

From the comments below the article they have their own covid board. How valid is this comment?

" The transmission rates are very high in vaccinated populations, there is very good reason to believe that their antibodies will cause and accelerate the emergence of vaccine escape mutations. This can bring us back to square one very quickly. It would make no sense to me if the strategy to exit this situation is a new escape variant based vaccination campaign. The modelled and witnessed number of delta infections in heavily vaccinated populations runs into the tens of millions. The probability of complete vaccine escape is 100%, most likely this year."
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Zobel
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In reply to texan12 • 11:51a, 8/1/21
AG
Nothing wrong with the stuff going to the liver. It's just that if you're trying to target a specific organ that can be difficult.

That comment is being pushed by fringe-types like Dr. Geert Vanden Bossche. The problem with the theory is we have no small amount of vaccinations for other viruses. Have any of our vaccination campaigns against polio, measles, smallpox, etc resulted in complete vaccine escape???
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texan12
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In reply to Zobel • 11:55a, 8/1/21
Diyala Nick
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12:02p, 8/1/21
AG
Pair this up with Deep Mind's release of structural models for most of the human proteome, and things are likely to look different soon.
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Bucketrunner
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2:03p, 8/1/21
How ironic that China's release of this could result in a cure for cancer.

As to mutations: no sane person can believe Americans will stand for another lockdown and muzzles. I guess we're going to find out who is strong enough to live in tomorrow's world. Darwin!
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