Is Celiac a co-morbidity issue impacting COVID-19?

2,073 Views | 21 Replies | Last: 3 yr ago by Windy City Ag
buffalo chip
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S
I have two sons and one granddaughter who have Celiac disease. I am interested to hear what the TA medical community says.
Thanks...
KidDoc
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AG
No. It is not auto immune is an allergic reaction.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
AustinAg2K
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KidDoc said:

No. It is not auto immune is an allergic reaction.


I'm fairly certain this isn't correct. Celiac is an auto immune disorder (it's more than just a gluten allergy); however, there is currently no evidence that celiac patients have a more severe reaction to Covid.
KidDoc
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AG
AustinAg2K said:

KidDoc said:

No. It is not auto immune is an allergic reaction.


I'm fairly certain this isn't correct. Celiac is an auto immune disorder (it's more than just a gluten allergy); however, there is currently no evidence that celiac patients have a more severe reaction to Covid.
No it is an allergic reaction that destroys the gut epithelium, generally IgM/IgG mediated not IgE like most allergic reactions. If you avoid gluten it does not happen, thus not auto-immune which is where the body attacks itself no dietary modification helps with autoimmune disease. The treatment for Celiac is not immunosuppression.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
bay fan
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S
AustinAg2K said:

KidDoc said:

No. It is not auto immune is an allergic reaction.


I'm fairly certain this isn't correct. Celiac is an auto immune disorder (it's more than just a gluten allergy); however, there is currently no evidence that celiac patients have a more severe reaction to Covid.
Often, arguing with a doctor in regards to medical things doesn't work the way you think!
AgsMyDude
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AG
AustinAg2K said:

KidDoc said:

No. It is not auto immune is an allergic reaction.


I'm fairly certain this isn't correct. Celiac is an auto immune disorder (it's more than just a gluten allergy); however, there is currently no evidence that celiac patients have a more severe reaction to Covid.


I'm fairly certain this isn't correct.
buffalo chip
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S
Thanks. As often on TA, things can get a little muddled. I appreciate that this forum has a doctor tag to help sort it out. I choose to believe the Kid Doctor. Again, thank you!
AustinAg2K
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I stand by my statement.

https://celiac.org/about-celiac-disease/what-is-celiac-disease/

"Celiac disease is a serious autoimmune disease that occurs in genetically predisposed people where the ingestion of gluten leads to damage in the small intestine."

https://www.mayoclinic.org/diseases-conditions/celiac-disease/symptoms-causes/syc-20352220

"Celiac disease, sometimes called celiac sprue or gluten-sensitive enteropathy, is an immune reaction to eating gluten, a protein found in wheat, barley and rye."

https://www.webmd.com/digestive-disorders/celiac-disease/celiac-disease#1

"Celiac disease is an autoimmune disorder that's triggered when you eat gluten"

https://medlineplus.gov/celiacdisease.html

"Celiac disease is an immune disease in which people can't eat gluten because it will damage their small intestine"

https://celiac.org/about-celiac-disease/related-conditions/autoimmune-disorders/

"Celiac disease is an autoimmune disorder."

https://www.beyondceliac.org/celiac-disease/

"Celiac disease is:
  • A serious autoimmune disease"

https://www.celiac.ca/gluten-related-disorders/atypical-symptoms/

"Celiac disease is also an autoimmune disorder, in which the immune system attacks the lining of the small intestines and damages the villi"

https://pubmed.ncbi.nlm.nih.gov/16214317/

"Celiac disease, which results from an immune reaction to ingested cereal gluten proteins, has several autoimmune features. In particular, celiac disease patients produce highly disease specific IgA and IgG autoantibodies to tissue transglutaminase when they are on a gluten-containing diet, and they have small intestinal intraepithelial lymphocytes which can mediate direct cytotoxicity of enterocytes expressing MIC molecules in an antigen non-specific manner. Similar to typical autoimmune disorders, celiac disease has a multifactorial aetiology with complex genetics, and several autoimmune diseases are commonly presented by patients with celiac disease. Much has been learned about the immunology of celiac disease in recent years, and there is overwhelming evidence that the immune response to gluten is central to the pathogenesis. In light of this, the many autoimmune phenomena associated with celiac disease are thought-provoking, and they challenge us to rethink the boundaries between autoimmunity and immunopathology."

https://www.healthline.com/health/autoimmune-disorders

https://www.aarda.org/diseaselist/

https://www.autoimmuneregistry.org/the-list

https://nationalceliac.org/celiac-disease-questions/gluten-allergy/#:~:text=Answer,term%20to%20use%20for%20CD.

"Celiac disease (CD) is not an allergy but an autoimmune disease. People with CD have an autoimmune reaction involving IgA antibodies when gluten is ingested. An allergy is different and involves a different branch of the immune system, so the term gluten allergy is not the correct term to use for CD"
basketaggie
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AG
I went back and forth about saying something.

I was diagnosed with celiac over 10 years ago. I have always been told it's autoimmune. You can see the Celiac Disease Foundation also states it is: https://celiac.org/about-celiac-disease/related-conditions/autoimmune-disorders/
I found other medical sources as well: https://pubmed.ncbi.nlm.nih.gov/16214317/
The Canadian Celiac association also lists it as an autoimmune disorder.
I can see Kid Doctor's point of view- but for those of us who do suffer with it, our doctors have told us that is in fact autoimmune.
tfunk02
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AG
Good information here. It also states that Celiac is NOT an allergic reaction.

https://celiac.org/celiac-disease-and-covid-19/
Windy City Ag
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AG
Quote:

Often, arguing with a doctor in regards to medical things doesn't work the way you think!

I have a child with type 1 and every specialist I have ever worked with as well as his pediatrician have listed Celiac disease in the family of autoimmune disorders. The Celiac Disease Foundation spells it out rather clearly.

Quote:

Celiac disease is an autoimmune disorder. People with one autoimmune disorder are prone to getting other autoimmune disorders.
https://celiac.org/about-celiac-disease/related-conditions/autoimmune-disorders/

I have read stuff from the Cleveland Clinic, the Mayo Clinic, and a ton of other places regarding autoimmune disorders and Celiac has always been included.

I am no doc so maybe there is something more nuanced or scientific that I am missing in the discussion.
Windy City Ag
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AG
Quote:

If you avoid gluten it does not happen, thus not auto-immune which is where the body attacks itself no dietary modification helps with autoimmune disease. The treatment for Celiac is not immunosuppression.

Having spent too many years trying to understand autoimmune disorders, I was never under the impression that immunosupression as treatment was the definition. The definition to me has always revolved around an abberant immune reaction . . . "the immune system attacks healthy tissue/cells/whatever by mistake"

In the case of celiac, it is not the allergy that is the issue but the the fact that the immune system responds mistakenly and attacks the small intestine.

Atreides Ornithopter
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AG
I would claim it isnt the true definition of an AUTOimmune disorder. It is probably more appropriate to call it a GLUTENimmune disorder.

Its like claiming obesitiy is an autofood disorder.
buffalo chip
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shalackin
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AG
Wife has Celiac. We have been told by all our docs that it is an AI disease.
KidDoc
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AG
Good discussion thanks for the info!
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
KidDoc
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AG
I've diagnosed several Celiacs in my 20 years but of course they are mostly managed by the GI docs. I still don't think Celiac is a risk factor for severe COVID.

No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
AeroAg1
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AG
basketaggie said:

I went back and forth about saying something.

I was diagnosed with celiac over 10 years ago. I have always been told it's autoimmune. You can see the Celiac Disease Foundation also states it is: https://celiac.org/about-celiac-disease/related-conditions/autoimmune-disorders/
I found other medical sources as well: https://pubmed.ncbi.nlm.nih.gov/16214317/
The Canadian Celiac association also lists it as an autoimmune disorder.
I can see Kid Doctor's point of view- but for those of us who do suffer with it, our doctors have told us that is in fact autoimmune.

Folks are still learning about Celiac on a daily basis including our family. Our GI docs say it's autoimmune.
AeroAg1
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AG
bay fan said:

AustinAg2K said:

KidDoc said:

No. It is not auto immune is an allergic reaction.


I'm fairly certain this isn't correct. Celiac is an auto immune disorder (it's more than just a gluten allergy); however, there is currently no evidence that celiac patients have a more severe reaction to Covid.
Often, arguing with a doctor in regards to medical things doesn't work the way you think!
Wow. When calling your shot goes wrong!
AustinAg2K
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tfunk02 said:

Good information here. It also states that Celiac is NOT an allergic reaction.

https://celiac.org/celiac-disease-and-covid-19/
I feel like this post got lost amongst the auto-immunity discussion. The link from tfunk02 is the most relevant information for the original post. There are a lot of questions answered with regards to Celiac and Covid. It certainly sounds like for most Celiac patients, Covid is no more of a concern than it is for non-celiac patients, which is essentially what KidDoc originally said, but the link goes into a lot more detail.
Windy City Ag
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AG
Quote:

I still don't think Celiac is a risk factor for severe COVID.

Thanks KidDoc . . .that is the same feedback we have received for my son. We were scared to death at first but the data trickled in that Type 1's have no elevated exposure if the condition is even decently controlled.
KidDoc
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AG
Windy City Ag said:

Quote:

I still don't think Celiac is a risk factor for severe COVID.

Thanks KidDoc . . .that is the same feedback we have received for my son. We were scared to death at first but the data trickled in that Type 1's have no elevated exposure if the condition is even decently controlled.

Yes my 22 year old son is a Type 1 DM since age 8 so I have been very keyed into this data. His A1C has been 6-8% over the last year so I think he will be fine if he gets it.

No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
Windy City Ag
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AG
Such a frustratingly small world with Type 1 DM . . . .luckily the technology and tools available make the monitoring and treatment so much more manageable. Thank goodness ffor CGM and the evolved pump technology. I am hoping within my boy's lifetime that the islet cell treatments advance enough to serve as some sort of functional cure. Keeping my fingers crossed.
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