haven't heard of it like I have HCQ or Remdisivir.
I agree I am surprised Leronlimab was not used instead of REGN-COV2. Knowing that Covid-19 is a probable RANTES disease and Leronlimab disrupts the RANTES pathway in addition to decreasing the viral load like REGN-COV2.robdobyns said:
Unfortunately this antibody does not calm or prevent the cytokine Storm nor restore normal immune system functions. I presume it does lower viral load.
The monoclonal antibody Leronlimab does all three and has zero side effects. It has completed a successful phase 2 study on mild/moderate Covid. The FDA is presently doing an interim analysis of the phase 3 study on severe/critical patients. POTUS should be given Leronlimab ASAP.
I agree with steroids and personally I would add Quercetin and NAC as well.Marcus Aurelius said:
Vit D, Zinc, aspirin, melatonin. All have some evidence (except aspirin) of benefit but nothing earth shattering. I'd Rx him with steroids as well. Can't comment on the "antibody" treatment.
Reveille said:I agree with steroids and personally I would add Quercetin and NAC as well.Marcus Aurelius said:
Vit D, Zinc, aspirin, melatonin. All have some evidence (except aspirin) of benefit but nothing earth shattering. I'd Rx him with steroids as well. Can't comment on the "antibody" treatment.
Quote:
I've not seen a "immunosuppressed" patient do poorly from covid since March. In fact - it may be protective. I.e. cytokine storm, tociluzimab, etc.
Kool said:Reveille said:I agree with steroids and personally I would add Quercetin and NAC as well.Marcus Aurelius said:
Vit D, Zinc, aspirin, melatonin. All have some evidence (except aspirin) of benefit but nothing earth shattering. I'd Rx him with steroids as well. Can't comment on the "antibody" treatment.
Would you wait on steroids and only give once inflammatory markers start to go up, or symptoms worsen, so as not to Immunosupress early on?
jamey said:
Did i hear right that Trumps Dr is a DO
robdobyns said:
Trump will be given Leronlimab in the next 2-3 days according to talk show host Dr Michael Savage. He's been in contact with Trump's people.
Are you using Methylprednisolone or straight prednisone, and in what dosages, based on the mythical "70 kg adult" that I, and possibly you, heard about in med school?Reveille said:Kool said:Reveille said:I agree with steroids and personally I would add Quercetin and NAC as well.Marcus Aurelius said:
Vit D, Zinc, aspirin, melatonin. All have some evidence (except aspirin) of benefit but nothing earth shattering. I'd Rx him with steroids as well. Can't comment on the "antibody" treatment.
Would you wait on steroids and only give once inflammatory markers start to go up, or symptoms worsen, so as not to Immunosupress early on?
I am now giving everyone steroids at the time of diagnosis. Working very well, use either inhaled budesonide or oral prednisone for 5 days if they don't have a nebulizer.
Kool said:Are you using Methylprednisolone or straight prednisone, and in what dosages, based on the mythical "70 kg adult" that I, and possibly you, heard about in med school?Reveille said:Kool said:Reveille said:I agree with steroids and personally I would add Quercetin and NAC as well.Marcus Aurelius said:
Vit D, Zinc, aspirin, melatonin. All have some evidence (except aspirin) of benefit but nothing earth shattering. I'd Rx him with steroids as well. Can't comment on the "antibody" treatment.
Would you wait on steroids and only give once inflammatory markers start to go up, or symptoms worsen, so as not to Immunosupress early on?
I am now giving everyone steroids at the time of diagnosis. Working very well, use either inhaled budesonide or oral prednisone for 5 days if they don't have a nebulizer.
I'll be the first to admit that I use steroids like water without clear FDA indication for various head and neck infections, mostly because I don't want to risk upper airway inflammation. I just looked at the IDSA recs for steroids in COVID, current rec was for severe and critically ill, requiring supplemental O2, etc.
ISDA steroids and COVID-19
I've only had to directly treat a couple of patients with COVID so far, because their PCP had not much to offer, and I was glad to have this thread to guide what I was doing. It was a married couple who are both patients and friends. I ended putting him on steroids and called them in for her but she didn't use them (60X3,40X3,20X3,10X3). He was very close to getting admitted but stayed at home with close monitoring with a pulse-ox. This Forum and personal communications with Marcus Aurelius were invaluable in treating them.
I am pretty amazed that I haven't already gotten COVID, as have two of my partners, so I am getting my self-rx kit ready. I also just made my own 1:30 dilution of povidone iodine, and emptied it into nasal steroid bottles and plan to use it on clinic days.
Thanks for all the help.
No doubt people are exaggerating things, but are patients usually getting it right at the offset of an infection? It seems like you should wait a little bit so that the immune system response isn't suppressed too early.KidDoc said:
The doc on CBS this morning was so annoying. He was harping about how bad the side effects of dexamethasone are and how it should only be used in high risk. Give me a break, it is used every day long before COVID for viral conditions.
LOL It is disgusting the guys the network is putting on the air to misinform the public. It is making our jobs harder as unfortunately people believe it because it was on TV or the internet. There is not a day go by that a primary care physician or even an emergency room physician does not use steroids either oral, inhaled or injections.. They know or at least should know that what they are saying is completely not true. Short term steroid use is completely safe with only a few exceptions like an out of controlled diabetic.KidDoc said:
The doc on CBS this morning was so annoying. He was harping about how bad the side effects of dexamethasone are and how it should only be used in high risk. Give me a break, it is used every day long before COVID for viral conditions.
[Reminder that the political comments belong over on the PoliticsKidDoc said:
The doc on CBS this morning was so annoying. He was harping about how bad the side effects of dexamethasone are and how it should only be used in high risk. Give me a break, it is used every day long before COVID for viral conditions.
These tweets have been taken down??, the CYDY people aren't verifying this information. CYDY is a pump/dump stock and Savage could easily be an investor and was advised by lawyer to remove.robdobyns said:
Trump will be given Leronlimab in the next 2-3 days according to talk show host Dr Michael Savage. He's been in contact with Trump's people.