https://www.nejm.org/doi/full/10.1056/NEJMoa2020283?query=featured_home
Interesting study from Spain, Italy 1980 COVID-19 pts. Genome wide 8,582,968 single-nucleotide polymorphisms (SNP) genotype analysis. Compared to control group. 2 loci statistically significant allele variants: 3p21.31 which encodes SLC6A20, LZTFL1, CCR9, FYCO1, CXCR6, and XCR1 genes. They express proteins highly found in lung tissue. The allele variant led to varying levels of expression of these genes. The other SNP loci variant was 9q34.2, which very interestingly is the ABO system chromosomal region. They found a protective effect of group O and harmful effect of group A.
This helps explain heterogeneity in COVID-19 severity from person to person.
Interesting study from Spain, Italy 1980 COVID-19 pts. Genome wide 8,582,968 single-nucleotide polymorphisms (SNP) genotype analysis. Compared to control group. 2 loci statistically significant allele variants: 3p21.31 which encodes SLC6A20, LZTFL1, CCR9, FYCO1, CXCR6, and XCR1 genes. They express proteins highly found in lung tissue. The allele variant led to varying levels of expression of these genes. The other SNP loci variant was 9q34.2, which very interestingly is the ABO system chromosomal region. They found a protective effect of group O and harmful effect of group A.
This helps explain heterogeneity in COVID-19 severity from person to person.