To all the medical and science community.

I have been researching other options for the general population to consider during this time to help build immunity and/or help treat COVID-19 if you feel you may have been exposed.

Dr. Rev hit the nail on the head with Quercetin as an option for everyone to consider as a supplement today and I have provided some research on the HCQ thread on how to increase bioavailability to Quercetin or you can consider Quercetin Phytosome to increase bioavailability on its own. Quercetin is a Zinc Ionophore similar to Chloroquine and is available over the counter.

GLM (Glycerol Monolaurate) has some interesting properties as well and is also available over the counter. I was wondering who else on this forum has looked into this product to include in their daily regime.

One very interesting paper I found is attached below about its ability to inhibit human T-Cell signaling and function.

https://www.nature.com/articles/srep30225

GLM has also been tested in vitro by numerous institutions and by the CDC and it has been indicated that monolaurin may dissolve lipids in the fatty envelope around the virus, basically disintegrating the organisms' protective shield and causing them to be easily destroyed by the immune system.

Could this product potentially help with a reduction in Cytokine activity to help reduce CSS prevalence related to COVID-19 based upon the attached study?

Interesting. I'm still surprised that elderberry is on the do not use list. I always thought it was an antiviral.

Is this the supplement Monolaurin or something different? Don't see any GML supplements for sale.

And can anybody break this down in English?

Drifter. It is believed to have antiviral properties but as Dr. Rev stated in a previous post, it is also believed to cause an increase to immune activity. The Cytokine Storm you are hearing so much about as the culprit to many deaths is due to an overactive immune system.

GLM is also known as monolaurin

How does that interact with people on things like Warfrin and Aspirin and such for blood clotting.

Palovic said:

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The Cytokine Storm you are hearing so much about as the culprit to many deaths is due to an overactive immune system.

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Think I'll stick with Quercitin, Green Tea, and Zinc and steer clear of this one.

Palovic said:

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Drifter. It is believed to have antiviral properties but as Dr. Rev stated in a previous post, it is also believed to cause an increase to immune activity. The Cytokine Storm you are hearing so much about as the culprit to many deaths is due to an overactive immune system.

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So basically we want a strong immune system, but not too strong?

I can understand the confusion and I have used Elderberry all the time before COVID-19 became prevalent like many others.

A strong immune system is different than an overactive one due to immune resonse. Per what Dr. Rev stated, the potential risk associated with Elderberry with CV-19 may outweigh the potential benefit (if there is even one).

Player-this comment was in reference to Elderberry and not GLM

Roger that. My bad. So think GLM worth adding in to the mix if already taking quercitin, green tea, and zinc?

Player To Be Named Later said:

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Roger that. My bad. So think GLM worth adding in to the mix if already taking quercitin, green tea, and zinc?

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Jury still out. I am wanting to get some additional opinions on here from the forum first

Here is a link to the CDC study related to GLM (aka Monolaurin) on in vitro efficacy against enveloped RNA and DNA viruses. The actual report is behind a paywall but accessible through educational and/or research portals.

Abstract: Monolaurin alone and monolaurin with tertbutylhydroxyanisole (BHA), methylparaben, or sorbic acid were tested for in vitro virucidal activity against 14 human RNA and DNA enveloped viruses in cell culture. At concentrations of 1% additive in the reaction mixture for 1 h at 23C, all viruses were reduced in infectivity by >99.9%. Monolaurin with BHA was the most effective virucidal agent in that it removed all measurable infectivity from all of the viruses tested. The compounds acted similarly on all the viruses and reduced infectivity by disintegrating the virus envelope.

https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1745-4565.1982.tb00429.x

EDIT: Coronavirus is one of the RNA Families included in the study (not specifically COVID-19)

Will be impossible to track, but the relationship of death rates to fruit & vegetable intake would be interesting. An apple, a dish of blueberries, or a bowl of kale is probably the best supplement for most people.

94chem said:

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Will be impossible to track, but the relationship of death rates to fruit & vegetable intake would be interesting. An apple, a dish of blueberries, or a bowl of kale is probably the best supplement for most people.

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Agreed and I am not by any means a nutritionist nor Homeopathic junkie, but there could be a definitive link with diet and COVID-19 morbidity along with age and underlying conditions. A strong immune system is just as critical as an effective treatment for this virus it would appear.

Also, monolaurin is very similar to coconut oil. When reading in vitro studies, it is important to point out that if one chooses to self-medicate, try to stick to the natural things that are found in food, and not experimental pharmaceuticals that have no phase 3 testing.

Tx-Ag2010 said:

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Palovic said:

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Drifter. It is believed to have antiviral properties but as Dr. Rev stated in a previous post, it is also believed to cause an increase to immune activity. The Cytokine Storm you are hearing so much about as the culprit to many deaths is due to an overactive immune system.

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So basically we want a strong immune system, but not too strong?

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Check out the video I posted in this thread.

https://texags.com/forums/84/topics/3102701

94chem said:

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Also, monolaurin is very similar to coconut oil. When reading in vitro studies, it is important to point out that if one chooses to self-medicate, try to stick to the natural things that are found in food, and not experimental pharmaceuticals that have no phase 3 testing.

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Great point Chem as natural pathways should always be considered first, but also consider that Lauric acid is the component in coconut oil that in the body is converted to monolaurin (glycerin is also needed).

Lauric acid can be ingested in coconut oil and your body will convert it into monolaurin, but researchers are unsure of the conversion rates. Because of this, it's impossible to say how much coconut oil you would need to ingest to receive a therapeutic dose of monolaurin.

Monolaurin is also the monoglyceride found in human breast milk that helps infants with immune protection and it is GRAS per the FDA.

Palovic said:

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94chem said:

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Also, monolaurin is very similar to coconut oil. When reading in vitro studies, it is important to point out that if one chooses to self-medicate, try to stick to the natural things that are found in food, and not experimental pharmaceuticals that have no phase 3 testing.

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Great point Chem as natural pathways should always be considered first, but also consider that Lauric acid is the component in coconut oil that in the body is converted to monolaurin (glycerin is also needed).

Lauric acid can be ingested in coconut oil and your body will convert it into monolaurin, but researchers are unsure of the conversion rates. Because of this, it's impossible to say how much coconut oil you would need to ingest to receive a therapeutic dose of monolaurin.

Monolaurin is also the monoglyceride found in human breast milk that helps infants with immune protection and it is GRAS per the FDA.

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When I buy any vegetable oil, I never know what percentage exists as the triglyceride, diglyceride, or monoglyceride. I assume, perhaps wrongly, that none of it exists as the free acid. I have a colleague who is an expert in esterification. I'll see what he knows. Apparently the two free OH groups on the glyrerol are important?

Legalize-It-Ags said:

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Tx-Ag2010 said:

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Palovic said:

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Drifter. It is believed to have antiviral properties but as Dr. Rev stated in a previous post, it is also believed to cause an increase to immune activity. The Cytokine Storm you are hearing so much about as the culprit to many deaths is due to an overactive immune system.

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So basically we want a strong immune system, but not too strong?

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Check out the video I posted in this thread.

https://texags.com/forums/84/topics/3102701

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Great video. Really helps provide a Laymens perspective to the mechanisms in play. A majority of people I speak to daily have no idea what a Cytokine Storm is nor how the immune system works. Education is always the first step in any treatment.

In relation to Monolaurin and its effect on T-cells, I am still awaiting feedback from some specialist both offline and online.

In the study I attached initially it is states the following: "Collectively, we found that GML is a potent suppressor of T cell functions and signaling by altering T cell plasma membrane lipid dynamics. These findings establish GML as a novel immunosuppressant, in addition to being an antimicrobial agent. Understanding the direct impact of this chemical on human health is integral for the proper utilization of GML in its various roles.

https://www.nature.com/articles/srep30225

In Cytokine Storms, the Laymens mechanism has cytokines signal immune cells such as T-Cells and macro****es to travel to the site of infection (in the case of CV-19, the lungs). In addition, cytokines activate those cells, stimulating them to produce more cytokines.

The question I have posed to my outside contacts as well as any medical/science professional here is could GML serve as viable immunosuppressant to help general population curb cytokine response due to CV-19 if taken as prophylactic?

Older and more recent data indicate that the cytokine storm associated with severe pulmonary deterioration in SARS (Liu et al, JCI Insight 2019- references in this paper detail evidence from several other studies also) and MERS (and now with emerging data from COVID (SARS-COV-2)) does not derive from cognate immunity (ie, T cells) but rather innate immunity (viz, macro****es/monocyte lineages). Consistent with that is the cytokine profile that is predominated by IL6, TNF and IL1- cytokines typical of macro****e origin.

The mechanism of pulmonary deterioration demonstrated in these studies is unusual in that the normally protective antibody response becomes pathogenic, where anti-COVID antibodies (specifically antibodies against the spike protein of the virus) opsonize the COVID particles, following which the antibodies bind to the high affinity Fc receptor (CD64) on macro****es (specifically M1 type macro****es), activating them and causing cytokine release.

This unusual mechanism by which COVID antibodies turn the immune system against the host is not unique- in addition to MERS and SARS it is also well known to occur with respiratory syncytial virus in children (RSV) and is the major reason why vaccine efforts in RSV have failed. Antibody responses to the first dengue infection are the reason why upon preexposure to dengue, that the patients die of hemorrhagic fever.

Although this is a scary scenario, there are multiple potential therapeutic approaches to interrupt this anti-COVID antibody driven pathology. We are in conversations with a few companies trying to convince them to take their currently FDA approved and marketed drugs to interrupt this pathway.

As others have mentioned here and elsewhere, this is preferably done within the context of prospective clinical trials.

One addendum- it is our opinion (and that of several of my immunologist colleagues) that optimal approaches toward mitigating/preventing the cytokine storm is to act proximal to cytokine release at the level of antibody interaction with the macro****e- ie, to prevent cytokine generation rather than blunting the action of cytokines once they have been generated.

woodlees said:

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One addendum- it is our opinion (and that of several of my immunologist colleagues) that optimal approaches toward mitigating/preventing the cytokine storm is to act proximal to cytokine release at the level of antibody interaction with the macro****e- ie, to prevent cytokine generation rather than blunting the action of cytokines once they have been generated.

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Great information. Thanks for sharing and as always; anything that is shared here is only for educational/informational purposes only.

Looks like Singapore already has a study in the works utilizing GLM to combat CV-19.

https://www.ateneo.edu/ls/sose/sose/news/research/potential-coconut-oil-and-its-derivatives-effective-and-safe-antiviral