Some interesting clinical points regarding COVID-19

18,757 Views | 89 Replies | Last: 4 yr ago by McInnis 03
Jet Black
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HotardAg07 said:

There are a lot of headlines popping up saying things like:

"86% of people with coronavirus are walking around undetected, study says"
https://nypost.com/2020/03/17/86-of-people-with-coronavirus-are-walking-around-undetected-study-says/?utm_source=reddit.com
That is referencing Chinese data.

"50-75% of COVID-19 cases are completely asymptomatic but contagious (a whole city got tested in Italy, ~3k population)"
https://www.repubblica.it/salute/medicina-e-ricerca/2020/03/16/news/coronavirus_studio_il_50-75_dei_casi_a_vo_sono_asintomatici_e_molto_contagiosi-251474302/?ref=RHPPTP-BH-I251454518-C12-P3-S2.4-T1

However, when I read that, it's not perfectly clear that these are patients never become symptomatic.

For example, it's possible that 100,000,000 people in the US could get Coronavirus, but if only 14% get symptoms and become confirmed cases, that would be 14,000,000 people with a death rate of 0.5% being 70,000 deaths, basically being a death rate similar to the flu.

But, it seems possible to me also that since CV is exponentially growing and that it has a 2-14 day incubation cycle, that it just means that most of the people at any given time are asymptomatic, just because they haven't reached the end of their incubation for most.


Couldn't an asymptomatic person progress to being symptomatic or they may never develop symptoms?
erudite
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I think you mean asymptomatic carrier. That's typhoid Mary. Someone who has the infection but consistently shows no symptoms.

Closest I know is asymptomatic spread (Maybe asymptomatic transmission?) is when people infected others, but are currently not symptomatic themselves. Eg; Jane is asymptomatic but spreads it to John. Jane then becomes ill.

Feel free correct me if I am wrong.


BTW, I found an article from Chinese news claiming this:
Quote:

"Data from Southern Technology University, Shanghai Transportation University, Wuhan Zhongnang hospital, Wuhan Jinyitan Hospital, and 8 other individual faculties et al. has shown the following:
A,B, O, AB blood types have different susceptibilities to novel-coronavrius. In summary, O blood type is least at risk and least likely to be infected. Whereas A type blood has a higher mortality and severity in infections and thus highest at risk.
If our resident doctor can debunk this that would be interesting. I don't see how blood types would affect the pathogen and disease intensity unless for some reason novel corona utilizes the antigens? Might be a case of them assuming correlation=causation.
Not a Bot
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AG
I'm A+.

That better not be right.
McInnis 03
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O blood type is also the most rare isn't it? May explain why it's least infected
Rock Too
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O is the most common, which would map with the high percentage of asymptomatic........but this all sounds like an internet rumor
Patentmike
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Rock1983 said:

O is the most common, which would map with the high percentage of asymptomatic........but this all sounds like an internet rumor
Some info...not a huge difference but enough it may suggest some biochemical detail about the virus

Quote:

The ABO group in 3694 normal people in Wuhan showed a distribution of 32.16%, 24.90%, 9.10% and 33.84% for A, B, AB and O, respectively, versus the distribution of 37.75%, 26.42%, 10.03% and 25.80% for A, B, AB and O, respectively, in 1,775 COVID-19 patients from Wuhan Jinyintan Hospital. The proportion of blood group A and O in COVID-19 patients were significantly higher and lower, respectively, than that in normal people (both P < 0.001).

Links a non peer reviewed publication

Preprint of paper

There may be a surface protein of the virus that looks enough like the A antigen that antibodies against the A antigen can attach.
PatentMike, J.D.
BS Biochem
MS Molecular Virology


Duncan Idaho
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can someone provide some context on what level/frequency of coughing means someone needs to get concerned?

Is it a consistent deep cough or is an occasional/few times a day cough like deric zoolander's black lung enough to be concerned?

adairtexas
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question as to why we are not using chloroquine to combat this untuil we can create a vaccine?

Chloroquine was used in China to shorten the illness and could to the spread. The French have cpome out with a clinical trila of current patients showing the drug has cut infection time in half and may be a
prophylactic. Backed up by US study.

https://www.connexionfrance.com/French-news/French-researcher-in-Marseille-posts-successful-Covid-19-coronavirus-drug-trial-results
KidDoc
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Duncan Idaho said:

can someone provide some context on what level/frequency of coughing means someone needs to get concerned?

Is it a consistent deep cough or is an occasional/few times a day cough like deric zoolander's black lung enough to be concerned?


Shortness of breath & dyspnea on exertion seem to be much more important than cough as far as prognosis.
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KidDoc
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adairtexas said:

question as to why we are not using chloroquine to combat this untuil we can create a vaccine?

Chloroquine was used in China to shorten the illness and could to the spread. The French have cpome out with a clinical trila of current patients showing the drug has cut infection time in half and may be a
prophylactic. Backed up by US study.

https://www.connexionfrance.com/French-news/French-researcher-in-Marseille-posts-successful-Covid-19-coronavirus-drug-trial-results
Interesting but we usually do not make widespread guidelines based on an unblinded, non placebo controlled study with 24 patients.
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Duncan Idaho
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Thanks. Still breathing fine.
Indignitas
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OP, any new updates or insights? Thank you again for sharing your experience here.
diamondag
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So just to confirm if one has allergies during this season and develops asthma like breathing problems, don't take the Advair?

I would not be able to detect if the breathing difficulties are simply the asthma from the allergy or it is Covid 19. usually while I sleep the mornings are difficult as it seems mucus starts to build in the lungs

as of now there is no issue but I already feel the lungs having issue with the allergy reaction as I do every year this week like clockwork

wife is a primary care specialist so I am now worried about confusion of the symptoms and the need for steroids because breathing becomes very difficult in a few weeks from now as in every year due to the allergies
fullback44
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adairtexas said:

question as to why we are not using chloroquine to combat this untuil we can create a vaccine?

Chloroquine was used in China to shorten the illness and could to the spread. The French have cpome out with a clinical trila of current patients showing the drug has cut infection time in half and may be a
prophylactic. Backed up by US study.

https://www.connexionfrance.com/French-news/French-researcher-in-Marseille-posts-successful-Covid-19-coronavirus-drug-trial-results
There's another thread where the Docs said we are now using it (or maybe hydrochloroquin) along with azithromician I believe as well as taking zinc .. 3 drugs seem to knock it out of the ball park.. I just hope their is plenty of hydrochloroquin to go around ?
Rutedown
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Infection_Ag,
Thoughts on Hydrochloroquine for COVID-19?
erudite
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Hmmm... now that I think of it we could probably do some napkin math and compare the ratio of the chinese population and cross check it with the study?
96AustinAg
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diamondag said:

So just to confirm if one has allergies during this season and develops asthma like breathing problems, don't take the Advair?

I would not be able to detect if the breathing difficulties are simply the asthma from the allergy or it is Covid 19. usually while I sleep the mornings are difficult as it seems mucus starts to build in the lungs

as of now there is no issue but I already feel the lungs having issue with the allergy reaction as I do every year this week like clockwork

wife is a primary care specialist so I am now worried about confusion of the symptoms and the need for steroids because breathing becomes very difficult in a few weeks from now as in every year due to the allergies
I don't think that's correct. Dr. Coates addressed the question on his mega-thread - I believe the steroid component doesn't get internalized/absorbed to the point where it would be impactful, and it's more important to protect your lung function. Without having my asthma under control, I would end up with lower respiratory issues from damn near every cold I got.
KR Training staff instructor - www.krtraining.com
KidDoc
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fullback44 said:

adairtexas said:

question as to why we are not using chloroquine to combat this untuil we can create a vaccine?

Chloroquine was used in China to shorten the illness and could to the spread. The French have cpome out with a clinical trila of current patients showing the drug has cut infection time in half and may be a
prophylactic. Backed up by US study.

https://www.connexionfrance.com/French-news/French-researcher-in-Marseille-posts-successful-Covid-19-coronavirus-drug-trial-results
There's another thread where the Docs said we are now using it (or maybe hydrochloroquin) along with azithromician I believe as well as taking zinc .. 3 drugs seem to knock it out of the ball park.. I just hope their is plenty of hydrochloroquin to go around ?
After the news conference @ lunch today I had my doc call out my RX. With my risk of exposure it is worth it to me to just take it daily for the next few months.
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KidDoc
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diamondag said:

So just to confirm if one has allergies during this season and develops asthma like breathing problems, don't take the Advair?

I would not be able to detect if the breathing difficulties are simply the asthma from the allergy or it is Covid 19. usually while I sleep the mornings are difficult as it seems mucus starts to build in the lungs

as of now there is no issue but I already feel the lungs having issue with the allergy reaction as I do every year this week like clockwork

wife is a primary care specialist so I am now worried about confusion of the symptoms and the need for steroids because breathing becomes very difficult in a few weeks from now as in every year due to the allergies
Stay on advair. It is systemic steroids that need to be used with caution. You would have to use your advair daily for 3 years to get the same dose as a few days of systemic steroids.
No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. See full Medical Disclaimer.
diamondag
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Kid doc and 96austinag... thank you for the info

This really eases my concern and I'm hoping this new treatment is the answer getting our country back on track

Prayers !!!
McInnis 03
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