Ahh, different type of "moisture".
I would think that worst case, and assuming a good foam installation, that your subfloor gets wet in the event of any leaks, but that would be it. In that case you do what you are going to do regardless - mop up standing water and get air moving on the subfloor to wick out and dry the moisture. It may take a little longer if you have an adhered foam on the underside, but really it shouldn't be much or any appreciable amount of time.
Sealing off the skirting is a great start, but you'll never de-humidify the ground beneath the house. Not in Beaumont anyway. You'd have to install some type of heating system for the subgrade below the house for that to become a remote possibility, and then you are talking about beaucoup dinero.
Sealing off the underside of the house from air infiltration (or at least freely moving air) is probably the cheapest and fastest route. Keep the air from flowing under the house and you can probably reduce the freezing floors in the winter and cooling loss in the summer significantly.