HNIC, you're lying through your teeth if you think chemistry won't be an issue. It might be masked by how stunningly awful the East is, but there a ton of moving parts at works. It's going to take time for them to figure out what they are doing.
I think the biggest problem with this team is going to be the bench units defense. They are going to hemorrhage points when LeBron sits. Their defense was already suspect. Now add in DWade and Rose.