HumbleAg04 said:
This is a very vocal F-150 board. Great truck. Go for it.
Can disable the AFM/DFM for $200 and solve the lifter issue.
That will not solve the lifter issue. It might help prevent it, but the bigger problem is the lifter design. The roller freezes up and eats into the cam, sending metal shavings through your oil system. The only way to prevent it completely is to pull the heads, replace the lifters, swap cams, and delete the DOD equipment, then tune. About $4K - $5K to delete, $8K -$10K to repair after the fact (if you fix it right which means replace the engine thanks to metal in your oil system). You could do all the work yourself for $2K - $3K before the failure, if you're mechanically inclined.
That being said, once you do the delete, you should have a really solid engine that will go for 250K+ miles with little drama.
Hemis have lifter issues, ecoboost have cam phaser issues, coyotes have had a few issues depending on generation, and even some 7.3L Fords (without DOD) have experienced lifter failure. Pick your poison.
Manufacturers have had to sacrifice reliability across the board to satisfy federal regulators and it isn't getting any better anytime soon.