the fastest way i have found (i can go from college station to kingsville in 4 1/2 hours going the speedlimit) is:
77 to 59.
59 to Wharton.
On the north side of wharton take Hwy 60...go left over the overpass and right at the stopsign...go to blinky light and turn left onto 60.
Follow 60 through East Bernard to Wallis.
Left on Hwy 36 in Wallis (dead-end)
Stay on 36 through Sealy.
On the other side of Sealy turn right on 331.
Follow to dead-end, turn right.
Make first left...back on 331.
Follow to dead-end.
turn right on 159.
Stay on 159 to Hempstead.
In Hempstead turn right at the stopsign then left at the light...
that is Hwy 6, follow it in to CS...
it sounds complicated, but its really much faster....
even going all the way to Bellville instead of Sealy and then hanging a right on 159 is, imo, faster than going down 77.
and i've been making the trip from CS to k-ville since 93..