If I had to choose one I would go with the .243. My decision is an emotional one however. Reason being I have carried one for years. Not because I had too, I have several other calibers (including 25-06) but because I want to. It is a pre 64 Model 70 featherweight (mfg 1957). Confidence has a lot to do with it but when I point this gun at deer...deer die. I shoot heavier bullets than most. I like Speer 105gr hot-cors at about 2900fps.
That being said I last year I had a 25-06 built on a Rem 700 action with a Shilen select match barrel. It did the deed well this past season in the hands of my son (I took a couple does with it also). It was loaded with Sierra 100gr gamekings at about 3250fps. I will be switching to something else this next year as I was not impressed with the Sierras ability to stay together and go out the other side. I am probably going to try partitions but have also loaded up some 100gr Hot-cors and they worked well on pigs this past weekend. Odd thing about this gun...shoots a 1 1/2in group at 100yds and a 1 1/2 in group at 200yds. Weird I have not played with loads much, I am sure I could do better than this accuracy.
THAT being said, I am having another gun built right now (ready any day

) on a Rem 700 action with a 26in stainless fluted Krieger barrel in you guessed it...243 win. I want to semi retire my present one (it is a family heirloom). I plan on shooting 90gr Hot-cors (I like Hot-cors) or 95gr Sciroccos. I have been reading some of the benchrest forums and those guys are getting some phenomenal velocity out of the .243 with some newer powders.
What I would really do is buy one of each.!!
Sorry for the long post, I could talk about this stuff all day.
[This message has been edited by swampstander (edited 4/17/2006 11:14p).]