While I'm all about overkill, 6" is way overkill for a typical shop foundation slab. Don't get me wrong, when I save up enough for a shop, it's going to likely have a 6" (maybe 8") thick mat slab, but I know full well that is in excess of anything normal.
Consider this - your driveway is 4" thick, and it gets regular use of vehicles weighing anywhere from 3000 pounds up to 7000+ pounds. Unless you are planning on putting fairly heavy machinery in your shop (large metal press or breaks), 4" with #4 reinforcing is more than enough.
I'm also not particularly fond of grade beams and prefer mat slabs instead. Easier to put in, less apt to have negative or detrimental effects from subsurface soil shrinking and swelling (which, and let's face it, nobody actually does good subgrade prep on anything in the residential category) and overall stronger IMO (not an engineer here, so I may be off on that last one).
But, your most used designs implement continuous exterior grade beams with usually a few crossing beams for additional support with a thinner slab on top, and that's likely going to get you the best overall price to dig, form, reinforce and place versus something not usually found in residential construction.
OP - don't overlook subgrade prep. Pay an engineer a few hundred bucks to come out and give you an assessment of your existing conditions, how much you really should overexcavate and what type of engineered fill you should bring in to actually put your foundation on. A few grand up front to get the subsurface conditions right will pay for itself many times over in the long run. The overwhelming majority of foundation issues on houses and light structures stems from craptastic subgrade prep and general poor placement practices of concrete. Eliminate those and you'll thank yourself 15 years from now when you aren't putting piers in under half your shop to get it close to level again.