If you really wanted to eliminate schedule variance in Fantasy Football, instead of head-to-head matchups, every week the top 6 teams in scoring that week would get a win and the bottom 6 teams would get a loss (assuming a 12-team league).
In one of my leagues, after this week, I will have finished in the top 6 in scoring in 9 out of 13 weeks. Under the system described above, I would be 9-4 and headed to the playoffs. Instead, I'm 4-9 and out of the playoffs. In just the last 4 weeks, I've finished 5th in scoring, 2nd, 5th, and this week 1st (most likely). That has resulted in loss, loss, loss, win.