we gonna listen to and get medical recommendations from a device sales rep now?

hell can't be worse than the covid doctors

amercer said:

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Whatever you are on, you have to stay on for life. (Which means actually taking every dose which is an incredible challenge for pretty much any drug for a chronic condition)

I think the hope is that once the weight is off, a lower dose (and maybe less effective) daily pill can work for maintaining weight loss.

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That would be great. I know most people over a certain age already take pills daily, so why not add one more that's helpful.

amercer said:

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That may be true. Lilly has a big advantage there too, as theirs is a small molecule and the cost of goods will be way less. But Novo got to the market first. Will be interesting to see if they learned anything from the last round where they botched the rollout and let Lilly lap them .

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Agreed. It looks like Novo knows their medication isn't as effective so is trying to play the pricing game and become the accessible option.

I currently have Tricare and I know that many soldiers have started taking these meds to get under strict weight requirements set by Hegseth. For a while you could get Zepbound or Wegovy with a prior authorization. Now Tricare makes you try Wegovy first due to cost reasons. My guess is when the pill comes out they will shift people to it as well due to costs.

This is interesting too because the Wegovy and Zepbound shots both make soldiers non-deployable as it requires refrigeration and injection, both deployment limiters. However, a pill form solves that issue from a readiness standpoint.

amercer said:

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The Lilly pill works better, but nothing (for now) will be as effective for weight loss as the injectables.

In any case the pills are going to be for maintenance once you've lost 80 pounds and don't want to jab yourself anymore. They will work great for that.

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I believe Lilly's is called orforglipron and correct, it is for weight loss maintenance as people move off their Zepbound injectable.

Lilly's drug is currently undergoing trial to be used from the start without injectable as well.

MookieBlaylock said:

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we gonna listen to and get medical recommendations from a device sales rep now?

hell can't be worse than the covid doctors

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This deserves a standing ovation. Bravo.

Merry Christmas to all you fat asses!

Teslag said:

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FIDO*98* said:

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Oral Semaglutide doesn't have near the same weight loss results and significantly more side effects. They're giving is away because they can't sell it. More window dressing

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The injection is 15% effective and the pill is 14%…

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That comment shows you have no idea wtf you're talking about.

FIDO*98* said:

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Teslag said:

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FIDO*98* said:

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Oral Semaglutide doesn't have near the same weight loss results and significantly more side effects. They're giving is away because they can't sell it. More window dressing

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The injection is 15% effective and the pill is 14%…

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That comment shows you have no idea wtf you're talking about.

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From the article...

Quote:

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The pills haven't been compared head-to-head in a clinical trial, but in separate studies, the Wegovy pill showed average weight loss of 14% over 64 weeks, compared with 2% for a placebo, while orforglipron showed 11% weight loss over 72 weeks on its highest dose, compared with 2% for the placebo group. Wegovy injection showed weight loss of 15% in its key trial, versus 2% for placebo, while Zepbound showed 21% on its highest dose, compared with 3% for those on placebo.

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You have a lot of nerve to accuse anyone of not knowing what they are talking about when you got the medications in question completely confused.

Teslag said:

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FIDO*98* said:

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Teslag said:

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FIDO*98* said:

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Oral Semaglutide doesn't have near the same weight loss results and significantly more side effects. They're giving is away because they can't sell it. More window dressing

---

The injection is 15% effective and the pill is 14%…

---

That comment shows you have no idea wtf you're talking about.

---

From the article...

Quote:

---

The pills haven't been compared head-to-head in a clinical trial, but in separate studies, the Wegovy pill showed average weight loss of 14% over 64 weeks, compared with 2% for a placebo, while orforglipron showed 11% weight loss over 72 weeks on its highest dose, compared with 2% for the placebo group. Wegovy injection showed weight loss of 15% in its key trial, versus 2% for placebo, while Zepbound showed 21% on its highest dose, compared with 3% for those on placebo.

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You have a lot of nerve to accuse anyone of not knowing what they are talking about when you got the medications in question completely confused.

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The meds show a roughly 80% efficacy in dropping 15%ish weight. That is remarkable efficacy in the weight loss world.

So they are 80% effective at causing 14-15% weight loss is the best way to describe it.

Sadly they are also very effective at causing constipation, muscle loss, gall bladder problems as well. These can be prevented or mitigated with a very careful diet but we all know how bad most Americans are at eating a proper diet.

Yep. We need to weigh whether those side effects are a good trade off to the complications of obesity. For many they probably are.

Question...

I dont know anything about GLP-1 meds.

If you take injections, do you have to inject yourself daily, weekly, monthly???

I don't think I could inject myself once, much less every day.

Weekly, and it's a tiny needle. I take a monthly injection for migraines and it's brutal. A 1" needle right into the stomach.

AgGrad99 said:

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Question...

I dont know anything about GLP-1 meds.

If you take injections, do you have to inject yourself daily, weekly, monthly???

I don't think I could inject myself once, much less every day.

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The needles are tiny, you don't even feel it.

Teslag said:

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Yep. We need to weigh whether those side effects are a good trade off to the complications of obesity. For many they probably are.

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Teslag said:

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JB99 said:

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$150 per pill?

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No per monthly supply

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I for one shall wait and see how much For Hims offers it.

Gordo14 said:

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MemphisAg1 said:

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Good Trump!

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Any administration would have approved this pill and Trump certainly didn't do it himself. But go for it

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Trump did run on lower RX prices and has delivered on that promise though.

amercer said:

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The Lilly pill works better, but nothing (for now) will be as effective for weight loss as the injectables.

In any case the pills are going to be for maintenance once you've lost 80 pounds and don't want to jab yourself anymore. They will work great for that.

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Better diet and exercise would be 10x better.

Teslag said:

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FIDO*98* said:

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Teslag said:

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FIDO*98* said:

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Oral Semaglutide doesn't have near the same weight loss results and significantly more side effects. They're giving is away because they can't sell it. More window dressing

---

The injection is 15% effective and the pill is 14%…

---

That comment shows you have no idea wtf you're talking about.

---

From the article...

Quote:

---

The pills haven't been compared head-to-head in a clinical trial, but in separate studies, the Wegovy pill showed average weight loss of 14% over 64 weeks, compared with 2% for a placebo, while orforglipron showed 11% weight loss over 72 weeks on its highest dose, compared with 2% for the placebo group. Wegovy injection showed weight loss of 15% in its key trial, versus 2% for placebo, while Zepbound showed 21% on its highest dose, compared with 3% for those on placebo.

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You have a lot of nerve to accuse anyone of not knowing what they are talking about when you got the medications in question completely confused.

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I worked for Novo and sold both Ozempic carried Rybelsus when I was in Pharma. Changing the name to Wegovy and adjusting dosages doesn't change the fact it's the same molecule and there are massive clinical differences and outcomes, regardless of what studies say. I am not speaking with nerve, I am speaking with a wealth of experience..

Novo wanted us pushing the you know what out of Rybelsus because the margins were significantly higher stamping out a pill versus building pens, cold storing, and distributing the injectable. Doctors weren't having it because they couldn't keep their patients on it.

It's funny, this little exchange makes me realize how stupid I must've sounded trying to make the same arguments with my doctors

FIDO*98* said:

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Teslag said:

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FIDO*98* said:

---

Teslag said:

---

FIDO*98* said:

---

Oral Semaglutide doesn't have near the same weight loss results and significantly more side effects. They're giving is away because they can't sell it. More window dressing

---

The injection is 15% effective and the pill is 14%…

---

That comment shows you have no idea wtf you're talking about.

---

From the article...

Quote:

---

The pills haven't been compared head-to-head in a clinical trial, but in separate studies, the Wegovy pill showed average weight loss of 14% over 64 weeks, compared with 2% for a placebo, while orforglipron showed 11% weight loss over 72 weeks on its highest dose, compared with 2% for the placebo group. Wegovy injection showed weight loss of 15% in its key trial, versus 2% for placebo, while Zepbound showed 21% on its highest dose, compared with 3% for those on placebo.

---

You have a lot of nerve to accuse anyone of not knowing what they are talking about when you got the medications in question completely confused.

---

I worked for Novo and sold both Ozempic carried Rybelsus when I was in Pharma. Changing the name to Wegovy and adjusting dosages doesn't change the fact it's the same molecule and there are massive clinical differences and outcomes, regardless of what studies say. I am not speaking with nerve, I am speaking with a wealth of experience..

Novo wanted us pushing the you know what out of Rybelsus because the margins were significantly higher stamping out a pill versus building pens, cold storing, and distributing the injectable. Doctors weren't having it because they couldn't keep their patients on it.

It's funny, this little exchange makes me realize how stupid I must've sounded trying to make the same arguments with my doctors

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Whoa. Respect. TexAgs knows stuff indeed.

FIDO*98* said:

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Teslag said:

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FIDO*98* said:

---

Teslag said:

---

FIDO*98* said:

---

Oral Semaglutide doesn't have near the same weight loss results and significantly more side effects. They're giving is away because they can't sell it. More window dressing

---

The injection is 15% effective and the pill is 14%…

---

That comment shows you have no idea wtf you're talking about.

---

From the article...

Quote:

---

The pills haven't been compared head-to-head in a clinical trial, but in separate studies, the Wegovy pill showed average weight loss of 14% over 64 weeks, compared with 2% for a placebo, while orforglipron showed 11% weight loss over 72 weeks on its highest dose, compared with 2% for the placebo group. Wegovy injection showed weight loss of 15% in its key trial, versus 2% for placebo, while Zepbound showed 21% on its highest dose, compared with 3% for those on placebo.

---

You have a lot of nerve to accuse anyone of not knowing what they are talking about when you got the medications in question completely confused.

---

I worked for Novo and sold both Ozempic carried Rybelsus when I was in Pharma. Changing the name to Wegovy and adjusting dosages doesn't change the fact it's the same molecule and there are massive clinical differences and outcomes, regardless of what studies say. I am not speaking with nerve, I am speaking with a wealth of experience..

Novo wanted us pushing the you know what out of Rybelsus because the margins were significantly higher stamping out a pill versus building pens, cold storing, and distributing the injectable. Doctors weren't having it because they couldn't keep their patients on it.

It's funny, this little exchange makes me realize how stupid I must've sounded trying to make the same arguments with my doctors

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This is a lot of words just to say nothing.

You probably think Wegovy and Ozempic are the same thing too.

You thought this article was about Rybelsus and got called on it because you didn't read it. You even told someone to read a product insert for a drug that isn't even released yet.

You just keep doubling down on ruhtard. Are you actually dumb enough to think that absorption is going to change because they changed the name? Ozympic and Wegovy are the exact same product with a different therapeutic curve. Ditto for Rybelsus and Wegovy oral. I pointed to the Rybelsus PI because it is published. Do you really think I am not aware that Wegovy oral has not yet been approved ?

I'll remind myself.... Never argue with stupid people, they will drag you down to their level and then beat you with experience,

Quote:

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Do you really think I am not aware that Wegovy oral has not yet been approved ?

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Yes. That much was patently obvious.

You claimed they were giving a product away because the couldn't sell it. It isn't even on the market yet. Just take the L buddy.