Psilocybin 400% more effective than antidepressants [SSRI]

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Troutslime said:

How do you get them?
There are a few states with legal access, there's some that grow healthily out of the ground, and others you can easily grow yourself [which is a very similar hobby to brew making in scope].

Illegally, you'll have to do your own ground research and learn your local laws so that you don't put yourself in a bad position. Simultaneously, when you take a substance you're not supposed to have due to local laws, id estimate a higher likelihood of a "bad trip" due to the added mental stress of illegality/etc.


Wait, just mushrooms in general or therapy with the mushrooms? The therapy side is expanding as people are getting certified to perform best practices on the psychedelic therapy+CBT and specifics on each psychedelic and their best use case is still being studied. It's cutting edge research so you might be able to jump into a medical study being performed by John's Hopkins or MAPS or some other entity.
WolfCall
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They are on to something with the treatment of depression and psychotic disorders with hallucinogens.

See below just a few of the titles of recent articles in pubmed with the search terms: hallucinogens depression.

Quote:

Items 1-11 of 11 (Display the 11 citations in PubMed)

1: Hwang KAJ, Saadabadi A. Lysergic Acid Diethylamide (LSD). 2021 Aug 6. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan. PMID: 29494014.


2: Orhurhu VJ, Vashisht R, Claus LE, Cohen SP. Ketamine Toxicity. 2021 Jul 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan. PMID: 31082131.


3: Artin H, Zisook S, Ramanathan D. How do serotonergic psychedelics treat depression: The potential role of neuroplasticity. World J Psychiatry. 2021 Jun 19;11(6):201-214. doi: 10.5498/wjp.v11.i6.201. PMID: 34168967; PMCID: PMC8209538.


4: Lowe H, Toyang N, Steele B, Valentine H, Grant J, Ali A, Ngwa W, Gordon L. The Therapeutic Potential of Psilocybin. Molecules. 2021 May 15;26(10):2948. doi: 10.3390/molecules26102948. PMID: 34063505; PMCID: PMC8156539.


5: Siegel AN, Meshkat S, Benitah K, Lipsitz O, Gill H, Lui LMW, Teopiz KM, McIntyre RS, Rosenblat JD. Registered clinical studies investigating psychedelic drugs for psychiatric disorders. J Psychiatr Res. 2021 Jul;139:71-81. doi: 10.1016/j.jpsychires.2021.05.019. Epub 2021 May 18. PMID: 34048997.


6: Rodrigues LS, Rossi GN, Rocha JM, L Osrio F, Bouso JC, Hallak JEC, Dos Santos RG. Effects of ayahuasca and its alkaloids on substance use disorders: an updated (2016-2020) systematic review of preclinical and human studies. Eur Arch Psychiatry Clin Neurosci. 2021 Apr 29. doi: 10.1007/s00406-021-01267-7. Epub ahead of print. PMID: 33914164.


7: Bouso JC, Ona G, Dos Santos RG, Hallak JEC. Psychedelic Medicines in Major Depression: Progress and Future Challenges. Adv Exp Med Biol. 2021;1305:515-533. doi: 10.1007/978-981-33-6044-0_26. PMID: 33834416.


8: Romeo B, Hermand M, Ptillion A, Karila L, Benyamina A. Clinical and biological predictors of psychedelic response in the treatment of psychiatric and addictive disorders: A systematic review. J Psychiatr Res. 2021 May;137:273-282. doi: 10.1016/j.jpsychires.2021.03.002. Epub 2021 Mar 7. PMID: 33730602.


9: Breeksema JJ, Koolen MHB, Somers M, Schoevers RA. Behandeling met psilocybine [Treatment with psilocybin: applications for patients with psychiatric disorders]. Ned Tijdschr Geneeskd. 2021 Jan 21;1654842. Dutch. PMID: 33560605.


10: Galvo-Coelho NL, Marx W, Gonzalez M, Sinclair J, de Manincor M, Perkins D, Sarris J. Classic serotonergic psychedelics for mood and depressive symptoms: a meta-analysis of mood disorder patients and healthy participants. Psychopharmacology (Berl). 2021 Feb;238(2):341-354. doi: 10.1007/s00213-020-05719-1. Epub 2021 Jan 11. PMID: 33427944; PMCID: PMC7826317.


11: De Gregorio D, Aguilar-Valles A, Preller KH, Heifets BD, Hibicke M, Mitchell J, Gobbi G. Hallucinogens in Mental Health: Preclinical and Clinical Studies on LSD, Psilocybin, MDMA, and Ketamine. J Neurosci. 2021 Feb 3;41(5):891-900. doi: 10.1523/JNEUROSCI.1659-20.2020. Epub 2020 Nov 30. PMID: 33257322; PMCID: PMC7880300.

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I went to a psychiatrist years ago and all they did was try to throw pills at me. I'm not sure if that tracks for everybody's experience. I enjoy reading about potential alternatives.

I recently weaned myself off of SSRIs and things like CBD/Delta 8 have genuinely helped me.
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Thunder18
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Sid Farkas said:

AggieVictor10 said:

shrooms
When Sid was at A&M, he and his buds picked them off of cow pies in a pasture just south of college station. Then very carefully identified them with a field guide. Tbh it's not a very good trip. Lots of nausea. Do not recommend


You can grow them in 90 second rice bags nowadays
BlackGold
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Troutslime said:

How do you get them?


Grow your own.
WolfCall
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If more physicians prescribed it wouldn't young adults, who wanted to space out, claim they were depressed and ask for "treatment"?
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WolfCall said:

If more physicians prescribed it wouldn't young adults, who wanted to space out, claim they were depressed and ask for "treatment"?
psychedelics are relatively unique in the "drugs" category in that they provide consciousness altering effects but do not provide the same mechanisms that addiction works within [dopaminergic reward system].

I've taken mushroom about 7 times in the last year and half and I wouldn't EXCEPT FOR wanting to learn more about the process to better assist others int heir future endeavors. I've had a few interesting trips and one "bad" one. There's literally no demand for me to try again except for personal research.

Secondly you assume there would be something "wrong" with kids seeking to alter/expand their consciousness and increase brain neuroplasticity.
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Dad Jokes said:

I went to a psychiatrist years ago and all they did was try to throw pills at me. I'm not sure if that tracks for everybody's experience. I enjoy reading about potential alternatives.

I recently weaned myself off of SSRIs and things like CBD/Delta 8 have genuinely helped me.
I love hearing this. It's representative of a large population of the globe let alone this country and even more so my friends and family I've assisted in sharing best practices.
Tyrone_The_Tuna
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Dad Jokes said:

I went to a psychiatrist years ago and all they did was try to throw pills at me. I'm not sure if that tracks for everybody's experience. I enjoy reading about potential alternatives.

I recently weaned myself off of SSRIs and things like CBD/Delta 8 have genuinely helped me.


I currently take them for my OCD, but have never tried CBD/Delta 8. Would you recommend?
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Tyrone_The_Tuna said:

Dad Jokes said:

I went to a psychiatrist years ago and all they did was try to throw pills at me. I'm not sure if that tracks for everybody's experience. I enjoy reading about potential alternatives.

I recently weaned myself off of SSRIs and things like CBD/Delta 8 have genuinely helped me.


I currently take them for my OCD, but have never tried CBD/Delta 8. Would you recommend?
My wife has OCD and has taken CBD before, it helps a little bit alone. But CBD + THC combinations are far more effective than CBD alone due to the interactions at the cannabinoid receptors (CB1/CB2).

I think self-experimentation is important, as dr's are massively under-studied on the subject matter and may not give relevant or expert guidance on the topic. I would make sure dosing yourself won't impede any current therapies ongoing. And if you are self-experimenting I HIGHLY recommend taking notes on your body and mental states before during and after the effects and increase/decrease dosage til you get the right mix. Start low and go slow.
Tyrone_The_Tuna
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administrative errors said:

Tyrone_The_Tuna said:

Dad Jokes said:

I went to a psychiatrist years ago and all they did was try to throw pills at me. I'm not sure if that tracks for everybody's experience. I enjoy reading about potential alternatives.

I recently weaned myself off of SSRIs and things like CBD/Delta 8 have genuinely helped me.


I currently take them for my OCD, but have never tried CBD/Delta 8. Would you recommend?
My wife has OCD and has taken CBD before, it helps a little bit alone. But CBD + THC combinations are far more effective than CBD alone due to the interactions at the cannabinoid receptors (CB1/CB2).


What has she taken?
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Tyrone_The_Tuna said:

administrative errors said:

Tyrone_The_Tuna said:

Dad Jokes said:

I went to a psychiatrist years ago and all they did was try to throw pills at me. I'm not sure if that tracks for everybody's experience. I enjoy reading about potential alternatives.

I recently weaned myself off of SSRIs and things like CBD/Delta 8 have genuinely helped me.


I currently take them for my OCD, but have never tried CBD/Delta 8. Would you recommend?
My wife has OCD and has taken CBD before, it helps a little bit alone. But CBD + THC combinations are far more effective than CBD alone due to the interactions at the cannabinoid receptors (CB1/CB2).


What has she taken?
There is a local lab here in town and they have the following brands in house: blisswellness.com and fluxxlab.com

Delta 8 THC | FluxxLab

full disclosure: ive owned a hemp business that produced 960 acres of hemp between 17 and 19, i explored selling the products as a white-label for fluxxlab/blisswellness but have not pursued the endeavor due to lack of time, but i thoroughly vouch for the efficacy of their products and work with the owner regularly on different formulations to trial. He created the patent for one of the first consumer cell phones and is loaded, owns half a mountain and is hilariously intelligent.
Fishin Texas Aggie 05
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Delta 8 is the same thing as marijuana?
administrative errors
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There is no such thing as marijuana, it's a nickname for cannabis sativa, the plant humans have harvested since before known civilization. Hemp, also a made up term [politically], is cannabis sativa containing less than .3% thc up to 1% thc depending on region.

Delta 8 thc is a cannabinoid primarily sourced from CBD isolate then converted to Delta 8 THC via heat time and isomerization.

Cannabiboids are compounds found both endogenous [internally in humans] and in multiple plants. Cannabinoids interact with the endocannabinoid systems [ECS] and contribute to the human experience in a myriad of ways.

Can I be provide more information or is this enough to start you off on your knowledge seeking journey?
MosesHallEnforcer
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Had a profound trip in the middle of the Amazon in 2006 my Junior year. We picked them following a herd a few hours before dark. The farmer invited us into his hut gave us water and was glad to see our sacks full of mushrooms.

I'll never forget that night the rest of my life. I kicked a bad smoking habit and got my **** together in all aspects of life after getting back. Never connected the 2, but after reading the recent research on smoking secession, I had a pretty big aha moment.
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MosesHallEnforcer said:

Had a profound trip in the middle of the Amazon in 2006 my Junior year. We picked them following a herd a few hours before dark. The farmer invited us into his hut gave us water and was glad to see our sacks full of mushrooms.

I'll never forget that night the rest of my life. I kicked a bad smoking habit and got my **** together in all aspects of life after getting back. Never connected the 2, but after reading the recent research on smoking secession, I had a pretty big aha moment.

I haven't yet explored nature while on psychedelics, mostly been in or around my house, on an airplane [low dose, best flight], and in a hot tub [with 3 others was the most joyous evening and tons of laughter]...worst was taking my heaviest dose then getting into bed with my wife knowing I'm taking a heavy dose, she was so worried about me it bled into my experience pretty negatively but that trip was the most intense for sure and felt like someone was trying to wake me up.... anyways I haven't completely integrated that experience yet.

Set and setting are so important for a good trip. [Research set and setting]
Fishin Texas Aggie 05
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Is there a difference between sativa and indica? Isn't there another specie as well?

I only remember that because I was a plant major
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Historically speaking yes, sativa, indica, 3rd type is eluding me as well right now. But due to breeding most are hybrids and very rare to find a pure indica/sativa/____. There is a lot of research going into developing "land races", aka the originals, that haven't been tampered with decades of breeding for specific high thc features that the black market wanted.

If you've ever been to a dispensary the people at the counter will try to talk about indica sativa etc, it's not accurate and is mostly attempting to describe the high from the bud instead the actual plant structure. When you see sativa or indica on edibles or concentrates, there's almost zero differentiation at that point.

Bud tenders aren't the best people to get advice from.
Fishin Texas Aggie 05
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Ruderalis

I googled it
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Fishin Texas Aggie 05 said:

Ruderalis

I googled it
if you're interested in cannabis genetics it's a fascinating rabbit hole I encourage any with the intellectual curiosity to dive into. Same with ECS research dive into it.
Fishin Texas Aggie 05
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administrative errors said:

Fishin Texas Aggie 05 said:

Ruderalis

I googled it
if you're interested in cannabis genetics it's a fascinating rabbit hole I encourage any with the intellectual curiosity to dive into. Same with ECS research dive into it.
ill be honest. I've never done a drug in my life unless you count alcohol, coffee, or cigars/pipes. Even with those i barley smoke anymore and maybe mix 1 drink on the weekends and its just bourbon on the rocks. I also drink 1 cup of coffee 4-5 days a week

while im sure the hybridization or GMO'ing of cannabis is interesting it seems to fall in line with all the other crops that are grown.

but thanks for sharing your experiences and i can live vicariously through them
administrative errors
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If you consider anything a drug then those are drugs too, you druggie of drugs that society enables/encourages excessive indulgence of.


Edit: these are all drugs that have been normalized and used recreationally and professionally for at least an American century.. think about all of the different products caffeine/alcohol are used in, all the innovation and new styles.... it's only the last 40 years we've had beer that had 10+% ABV due to yeast innovations among other technological advancements in brewing/etc.

With cannabis, we interrupted over 4+ thousand years of human history in the last century by making it an illicit substance. Cannabis is such a hearty plant and exceptionally strong healing agent of multiple degrees that despite the attempt to stamp it from existence it has found itself instead assisting in destroying the entity that banned its existence in the first place. May the green goddess find her rightful place in humanity.
Fishin Texas Aggie 05
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administrative errors said:

May the green goddess find her rightful place in humanity.
im more of a honey mustard guy but will change it up to sweet onion Vidalia
Fishin Texas Aggie 05
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but back to the topic does DMT and the mushroom drug relate to each other for benefits?
03_Aggie
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administrative errors said:

If you consider anything a drug then those are drugs too, you druggie of drugs that society enables/encourages excessive indulgence of.


Edit: these are all drugs that have been normalized and used recreationally and professionally for at least an American century.. think about all of the different products caffeine/alcohol are used in, all the innovation and new styles.... it's only the last 40 years we've had beer that had 10+% ABV due to yeast innovations among other technological advancements in brewing/etc.

With cannabis, we interrupted over 4+ thousand years of human history in the last century by making it an illicit substance. Cannabis is such a hearty plant and exceptionally strong healing agent of multiple degrees that despite the attempt to stamp it from existence it has found itself instead assisting in destroying the entity that banned its existence in the first place. May the green goddess find her rightful place in humanity.


Must be why the average life expectancy has decreased so much over the last 4+ thousand years. The classification of the worlds best medicine as an illegal substance. All this time and they just now figured it out. Who'd a thunk it.
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I'd hate to correlate that stat to anything other than cannabis being banned. Obvi choice. Definitively has nothing to do with any of the other things that have happened the past however many years... what was I thinking... if we bring cannabis back were all gonna only live to be 55 again at most!

With the utmost respect:
hph6203
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Microdosed mushrooms by drying them, grinding them in a coffee grinder, and mixing with cacao powder into gel capsules to get roughly the right dosage. Used them to tear depression. Works like a forced meditation/prevents ruminant thoughts. Only took 2.5 months and it worked really well.

They're pretty easy to grow. Just be careful, because you might end up with 200+ grams and only have a need for about 3. 200 grams is about 8-24 years worth of doses. Cost less than $200 for all of the equipment/materials.
03_Aggie
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Thanks for the respect. Also thanks for the humor of posting that video on the heels of your previous rambling post. Hint of irony there.
administrative errors
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Also. One of the great things about psychedelics/dmt/cannabis/etc, it helps you become okay with the unknown first by highlighting what is unknown to you and then exploring in it instead of ignoring it. When people didn't live as long theh didn't spend nearly as much of their generational wealth trying to eek out another few days[fear of unknown: death/loss]. I think I read that some large % of total wealth in a lifetime is spent trying to extend those last few years. Mostly by family unable to let go....

I ponder;

has global wealth consolidation increased with lifespan increases? I suspect it must.

You know when the average lifespan was around 40, we founded this country, now that the average is 69 or something we seem to be doing the opposite... as lifespans approach infinity so does communism?


I'm just trying to make leaps of logic as large as yours.
Funky Winkerbean
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Do you have a link to how to get started?
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Fishin Texas Aggie 05 said:

but back to the topic does DMT and the mushroom drug relate to each other for benefits?
specifically yes, in that they disrupt the Default Mode Network [DMN] and allow previously lightly connected parts of the brain brain to all become fully connected simultaneously [simplistically speaking] and participants will feel colors, smell sounds, etc [synesthesia] and usually will hallucinate and have a mystical experience at appropriate doses. The mystical experience is the event that helps people the most to transcend depression/addiction/etc as they come back with the ineffable knowledge that existences greater than your own exist [according to what I've been reading].

Dmt is a 15 minute session and they're exploring if it entails all the same benefits that psilocybin gives over an 8 hour session. And if so.. **** man. Mental health McDonalds are gonna pop up everywhere.
Fishin Texas Aggie 05
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thanks for your honest take and not being condescending.

i spend at least 2 hours on the road monday-friday and my YouTube algorithm is properly ****ed and even rabbit holes have rabbit holes


this ties well into my current binge which is on the philosophy of stoicism and cynicism
c-jags
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Interestingly, my wife and are watching 9 perfect strangers on Hulu and Psilocybin came up.

it's the poli board, but i'll still use the spoiler tag

9 strangers show up to a health retreat center and all are pretty damaged. weird nicole kidman starts having them do activities and they're all kinda a-holes to each other. she has them on a smoothie diet each day "tailor made" for each person. after the third day, they all start sharing a bit more and seem to be coming out of their shells. after one guy has a bit of a break through, his wife turns to the leader of the retreat and asks if shes' medictating them. she says yes, i'm using Psilocybin in microdoses."

they're all a bit upset, but decide to continue with the treatment.


i've never used any illegal drugs, but i find the conversation and possibilities interesting.
[url=https://en.wikipedia.org/wiki/Psilocybin_mushroom][/url]
hph6203
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