Pookers said:
BallerStaf2003 said:
So when people here post about hydroxychloroquine, it's all anecdotal and usually just some made up fake news. It's not a real clinical study.
This is different. This does show promise and very good early clinical results.
I'd be curious to know why this wasn't considered more.
Because its a generic, decades old drug that can't bring in massive profits. If Ivermectin is proven to be effective and safe then they cant issue the EUA for the fauci juices.
This doesn't hold up when you consider the staple and most widely used drugs in COVID19 have been steroids, which are generic, dirt cheap and don't make anyone any money. We used them because the evidence for benefit in certain COVID patients was overwhelming and based on high quality, well constructed studies. It also had a highly plausible mechanism of action.
The reason for the skepticism regarding ivermectin has largely been two fold
1: It lacks an obvious in vivo mechanism for treatment of COVID19, and the in vitro mechanisms observed occur at such high concentrations that they could never be achieved in the body. In the absence of a clearly plausible mechanism, people are going to be skeptical and often unwilling to devote time, money and energy to studying it.
2: In light of the above, the data that was collected was very much mixed. Generally you'd need something impressive at least on a small scale to change the thinking related to the first point. The majority of ivermectin studies that showed benefit, much like we saw with HCQ, were poorly designed and pretty clearly intended to arrive at a desired outcome. The difference is people still conducted large, well designed HCQ studies and it failed. This is a large multi-faceted study that while flawed is already better than anything that was ever produced with respect to HCQ.
It will be interesting to see where this goes from here though. I will say that, while nobody is going to be getting rich off ivermectin directly, if someone or some group is able to show this is anywhere near as effective as the outspoken proponents claim they will benefit greatly. That discovery would make the career of whoever discovers it. So there is incentive.
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