My vote goes straight to Jill Taylor of Home Improvement.

ETA:
Jill Taylor was the most annoying (for me) because she complained about everything and assumed that Tim was cheating on her around every corner.
Patricia Richardson imposed her own *****y nature from her personal life onto a sitcom. Nobody wants to listen to a washed up mother that got a psychology degree in her early 40's.

ETA:
Jill Taylor was the most annoying (for me) because she complained about everything and assumed that Tim was cheating on her around every corner.
Patricia Richardson imposed her own *****y nature from her personal life onto a sitcom. Nobody wants to listen to a washed up mother that got a psychology degree in her early 40's.