My ex and I own a business together. He and most of our 12 employees are away from their homes anywhere from 200-280 days a year. When we first started the business and were too dumb/scared to hire anyone, he had two years in a row he traveled 300+ days. The kids and I often traveled with him when we could, but it still was pretty miserable to be the sole parent at home most of the time. While there were a lot of factors that led to our divorce, the traveling certainly was a big one. In fact, the majority of our employees are also divorced or have generally unhappy personal lives, for what it's worth.
I know you didn't ask for marriage advice, OP, but if I could go back in time, I would tell myself that everything we gained from working and growing the business like we did was *not* worth the trade off of what it cost our family.