Ab IgG, Spike, Semi- Quant
Value: 7.19 index
Flag H.

My doctor said its on the low end but regardless, they recommend the booster. Im scheduled for my booster later today.

If its low, how low and based on what range- 1-10? 1-2500? Thanks!

The Texas cares antibody study thread would be a good place to start. It'll give you an idea of different levels based on different scenarios. For a summary, on page 9 I made a few plots summarizing the data up to that point.
https://texags.com/forums/84/topics/3208844/9#discussion

TLDR though is that assuming your test is using the same units, then yes that is low. The scale is 0-2500+ (where it cuts off) and I've seen the thoughts being <200 being the range where most would say think about a booster.

Answer: We do not know...

https://www.cdc.gov/coronavirus/2019-ncov/your-health/about-covid-19/antibodies.html#:~:text=We%20do%20not%20yet%20know,illness%20if%20you%20become%20infected.

When antibodies decrease below the threshold of protection, you may become more vulnerable to severe illness. We do not yet know what the threshold of protection for antibodies is for the virus that causes COVID-19 or how long it takes these antibodies to wane. Even after antibodies wane, your immune system may have cells that remember the virus that can act quickly to protect you from severe illness if you become infected.


Anyone saying otherwise is making things up and just giving best guess.....

After looking at that, its still hard for me to understand. I have very little information. I dont know if mine was an S or N protein test. The only other piece of information on my result is that the Standard Range is <1.00. So if its on a scale to 100, then I agree its low. But if its on a scale of 10, I would think its high.

What does the H mean?

Not trying to be "cute" but to be honest....you just need to decide if YOU want the booster or not.

My parents got it with no issues to date and so did my FIL.

As far as what the numbers tell you, my CDC article tells you what you need to know....nobody really knows...just guessing. CDC even admits there is a chance that even after antibodies "wane" your immune system may have a quick response....Kid Doc and others have mentioned this in the past as well....for better or worse, the CDC and White House and many organizations just take the "more is better" approach with vaccines for now...


edit: seems reasonable that you would take into account your own personal situation as well....over 45? overweight? other issues? if so...might not be a tough decision and would not worry too much about antibody counts...

KidDoc said:

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Timberwolf said:

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After looking at that, its still hard for me to understand. I have very little information. I dont know if mine was an S or N protein test. The only other piece of information on my result is that the Standard Range is <1.00. So if its on a scale to 100, then I agree its low. But if its on a scale of 10, I would think its high.

What does the H mean?

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H means it is out of normal range for that lab. Humans should not have antibodies to spike protein so anything detectable is H(high).

There is no defined threshold for immunity to COVID, especially Omicron which matches poorly with the current mRNA spike antibody vaccines. Your level is very low. Best guess is you want at least 200ish and higher is better. You should strongly consider a booster.

Yours is S(spike) protein as it says in the results.

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Was about to post this in the other thread where we had the original discussion but here seems like a good place too. I read this study this weekend that I thought you might find interesting.
https://www.nature.com/articles/s41591-021-01540-1
It gives some validation to your "guess" of 200ish.

TLDR is that their estimate is that 264 BAU/ml is 80% effective at providing immunity to symptomatic infection.

Thank you guys very much for the responses- good information for me.

BlackGoldAg2011 said:

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KidDoc said:

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Timberwolf said:

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After looking at that, its still hard for me to understand. I have very little information. I dont know if mine was an S or N protein test. The only other piece of information on my result is that the Standard Range is <1.00. So if its on a scale to 100, then I agree its low. But if its on a scale of 10, I would think its high.

What does the H mean?

---

H means it is out of normal range for that lab. Humans should not have antibodies to spike protein so anything detectable is H(high).

There is no defined threshold for immunity to COVID, especially Omicron which matches poorly with the current mRNA spike antibody vaccines. Your level is very low. Best guess is you want at least 200ish and higher is better. You should strongly consider a booster.

Yours is S(spike) protein as it says in the results.

---

Was about to post this in the other thread where we had the original discussion but here seems like a good place too. I read this study this weekend that I thought you might find interesting.
https://www.nature.com/articles/s41591-021-01540-1
It gives some validation to your "guess" of 200ish.

TLDR is that their estimate is that 264 BAU/ml is 80% effective at providing immunity to symptomatic infection.

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Thanks for sharing it that is pretty interesting! Two decades of dealing with viral pathogens in children has made me a fairly decent guesser.

KidDoc said:

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BlackGoldAg2011 said:

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KidDoc said:

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Timberwolf said:

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After looking at that, its still hard for me to understand. I have very little information. I dont know if mine was an S or N protein test. The only other piece of information on my result is that the Standard Range is <1.00. So if its on a scale to 100, then I agree its low. But if its on a scale of 10, I would think its high.

What does the H mean?

---

H means it is out of normal range for that lab. Humans should not have antibodies to spike protein so anything detectable is H(high).

There is no defined threshold for immunity to COVID, especially Omicron which matches poorly with the current mRNA spike antibody vaccines. Your level is very low. Best guess is you want at least 200ish and higher is better. You should strongly consider a booster.

Yours is S(spike) protein as it says in the results.

---

Was about to post this in the other thread where we had the original discussion but here seems like a good place too. I read this study this weekend that I thought you might find interesting.
https://www.nature.com/articles/s41591-021-01540-1
It gives some validation to your "guess" of 200ish.

TLDR is that their estimate is that 264 BAU/ml is 80% effective at providing immunity to symptomatic infection.

---

Thanks for sharing it that is pretty interesting! Two decades of dealing with viral pathogens in children has made me a fairly decent guesser.

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I thought so too, I was also intrigued about the hypothesis about a possible lack of secretory IgA on the mucosal surfaces being why we aren't seeing nearly as much sterilizing immunity. (Did some additional reading on that this morning which i found fascinating.)

and yea, that's why i did air quotes around the word guess, because calling your opinion a guess as you did isn't accurate in my mind. If I, a petroleum engineer, formed an opinion about necessary antibody levels, that would be a guess. When you form an opinion I would call it closer to something like a hypothesis. maybe that's the wrong word, but your "guess" for sure needs more weight than the word connotates.

I'm a huge fan of Flumist for kids specifically for the mucosal immunity. I know someone is working on an intranasal COVID vaccine which would be amazing.