I'm curious, how dangerous would all other corona viruses be to those currently at risk if they had never been exposed to them multiple times in their life including early childhood? Are we seeing SARS CoV2 really being similar with accept it being novel being why it is dangerous and so little risk to the young? Or, is it both?

This thread got me thinking about it. Worth reading the whole thread.

i think a lot of people are misunderstanding the mechanism behind "shift to endemicity" in a CoV.

it's not at all due to the *virus*. yes, endemic HCoVs have certain mutations (such as a preference for closed RBDs on Spike where the CTD is the RBD) but those are from...

— Jasnah Kholin - 8964 - ACAB - 💉💉 (@wanderer_jasnah) July 26, 2021

I have been wondering that too. Have gained a lot of new, wary respect for the common cold viruses after this pandemic.

The HCov-OC43 and 1889 pandemic link is fascinating.

I think i heard on Zdogg that it is theorized that traditional "common cold" viruses when exposed to native Americans for the first time caused ARDS symptoms similar to what we're seeing w SarscoV2