Real-time tracking of self-reported symptoms predict potential COVID-19

1,604 Views | 1 Replies | Last: 5 yr ago by amercer
Jmiller
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Published: 11 May 2020
https://www.nature.com/articles/s41591-020-0916-2#article-info
Quote:

Abstract

A total of 2,618,862 participants reported their potential symptoms of COVID-19 on a smartphone-based app. Among the 18,401 who had undergone a SARS-CoV-2 test, the proportion of participants who reported loss of smell and taste was higher in those with a positive test result (4,668 of 7,178 individuals; 65.03%) than in those with a negative test result (2,436 of 11,223 participants; 21.71%) (odds ratio = 6.74; 95% confidence interval = 6.317.21). A model combining symptoms to predict probable infection was applied to the data from all app users who reported symptoms (805,753) and predicted that 140,312 (17.42%) participants are likely to have COVID-19.
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https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41591-020-0916-2/MediaObjects/41591_2020_916_Fig1_HTML.png
a, Association between symptoms and the odds ratio of SARS-CoV-2 infection in 15,638 UK and 2,763 US participants who were tested via RT-PCR. Error bars represent 95% CIs. b,c, ROCs for prediction in the UK test set (b) and US validation set (c) of the risk of a positive test for SARS-CoV-2, using the following self-reported symptoms and traits: persistent cough, fatigue, skipped meals, loss of smell and taste, sex and age. Values for AUC, sensitivity (SE), specificity (SP), positive predictive value (PPV) and negative predictive value (NPV) are shown, with 95% CIs in parentheses.

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Sisyphus
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From the Nature study:
Quote:

We report that loss of smell and taste is a potential predictor of COVID-19 in addition to other, more established, symptoms including high temperature and a new, persistent cough. COVID-19 appears to cause problems of smell receptors in line with many other respiratory viruses, including previous coronaviruses thought to account for 1015% of cases of anosmia7,9.

We also identify a combination of symptoms, including anosmia, fatigue, persistent cough and loss of appetite, that together might identify individuals with COVID-19

I don't think that's a surprise to anyone but it is an interesting confirmation. Thanks for posting
amercer
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Sisyphus said:

From the Nature study:
Quote:

We report that loss of smell and taste is a potential predictor of COVID-19 in addition to other, more established, symptoms including high temperature and a new, persistent cough. COVID-19 appears to cause problems of smell receptors in line with many other respiratory viruses, including previous coronaviruses thought to account for 1015% of cases of anosmia7,9.

We also identify a combination of symptoms, including anosmia, fatigue, persistent cough and loss of appetite, that together might identify individuals with COVID-19

I don't think that's a surprise to anyone but it is an interesting confirmation. Thanks for posting


I think it's surprising (an good news) that there can be an algorithm to predict actual cases. Because pretty much everyone I know (and a lot I don't on texags) thinks they already maybe had it because of a stuffy head back in February. The seroprevalence numbers indicate infections probably aren't as widespread as people were thinking.
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