Moved from Round Rock to the Raleigh area over 5 years ago and we love it (posted on your other threads) and never want to leave. Charlotte and Raleigh would be your best bets...both booming and great areas. Charlotte is much closer to the Blue Ridge mountains and the "big city" of NC obviously. Raleigh makes all the great places for every list there is and is smaller, more laid back and part of the triangle (Durham, Raleigh, Chapel Hill). Can talk to this area much more since we live here. Raleigh housing is expensive and in great demand. Would look at the surrounding areas (cheaper, great schools, new construction, etc...). Construction is booming and Duke, UNC, WakeMed are the big players and great places of the big medical profession here and wouldn't imagine that being any problem for your wife.
I could go on and on, so let me know what else you would like to know. We go to the mountains as much as we can (average of 3 hrs from our house but it really depends where you go) and would kill to buy a cabin somewhere...but easy to rent all over the different places. Beach is 2 hrs away and the Outer Banks is about 3. Savannah, Charleston, DC all within 5 hrs and Orlando around 8.
Grew up in a small central Texas town, went to A&M and have lived in San Antonio, Bloomington, IN, Dallas and Round Rock and this is the best place hands down we have lived (minus Aggieland as that's it's own special category
). To each their own, but risking I will be run off this site...there are places outside of TX!